GC/MS Analysis and Compounds Isolation of Lycium shawii Petroleum Ether Seeds Extract for Regulating Nrf2/OH-1 Pathway, Oxidative Stress and Inflammation in Acrylamide- Induced Infertility in Female Rats.

Acrylamide is formed during heating of starchy foods at high temperature and induces reproductive toxicity. Our study is designed to evaluate the chemical constitution and anti-infertility effect of Lycium shawii seeds extract on female rats. Nutritional profile was estimated, and major active compounds were isolated and identified.

Mitigating Effect of Lepidium sativum Seeds Oil on Ovarian Oxidative Stress, DNA Abnormality and Hormonal Disturbances Induced by Acrylamide in Rats.

Acrylamide (ACR), an industrial compound, causes both male and female reproductive toxicity. Lepidium sativum seeds (L. sativum) (Garden cress) are known for their health benefits as antioxidant, antiasthmatic, anticoagulant, anti-inflammatory, and analgesic agents.

Biosynthesis of Zinc Oxide Nanoparticles Using Bacillus paramycoides for In Vitro Biological Activities and In Vivo Assessment Against Hepatorenal Injury Induced by CCl in Rats.

Recently, impressive developments in the field of nanotechnology have been achieved. The study aimed to synthetize zinc oxide nanoparticles (ZnONPs) from locally isolated terrestrial Bacillus paramycoides (MCCC 1A04098) bacteria and assess its role as antioxidant, antimicrobial, and anticancer agent. The antioxidant activity was done using the percentage of DPPH scavenging method.

Inflammatory mediators, oxidative stress and genetic disturbance in rheumatoid arthritis rats supported by alfalfa seeds metabolomic constituents via blocking interleukin-1receptor.

Rheumatoid arthritis (RA) is an autoimmune disease characterized by aggressive cartilage and bone erosion. This work aimed to evaluate the metabolomic profile of Medicago sativa L. (MS) (alfalfa) seeds and explore its therapeutic impact against RA in rats.

Chemical compositions of stem bark to alleviate liver complications in streptozotocin-induced diabetes in rats: Role of oxidative stress and DNA damage.

Context: Hyperglycaemia plays an important role in the development of non-alcoholic fatty liver disease, which is a common complication in diabetics.

Objective: The present study aimed to investigate the chemical composition and the efficacy of stem bark butanol fraction in ameliorating liver injury associated with diabetes induced by streptozotocin (STZ) in rats.

Materials And Methods: The butanol fraction was applied to high-performance liquid chromatography-mass spectrometry (HPLC/MS) to identify the most bioactive metabolites.

Profiling of secondary metabolites and DNA typing of three different Annona cultivars grown in Egypt.

Objectives: Natural products are often efficacious and safe alternatives to synthetic drugs. This study explored secondary leaves and bark metabolites profiles in extracts of a new Egyptian hybrid, Annona cherimola × Annona squamosa, known as Abdel Razek. This hybrid exhibited 100% similarity with A.

Chromosomal aberrations, DNA damage, and biochemical disturbances induced by silver nanoparticles in mice: role of particle size and natural compounds treatment.

Context: Nanotechnology is widely used nowadays in several fields of industry, engineering, and medicine, the biological action mechanisms of AgNPs, which mainly involve the release of silver ions (Ag), generation of reactive oxygen species (ROS).

Objective: The potential toxicity AgNPs of damages to hepatic cells, hesperidin, and naringin role for their protective effect against the increase of ROS due to AgNPs toxicity. They can be restored, most cellular biochemical parameters, genotoxicity, mutagenicity, and histopathological analysis.

seeds extract alleviate encephalopathy in streptozotocin-induced diabetes in rats: role of oxidative stress, neurotransmitters, DNA and histological indices.

Context: Diabetes mellitus (DM) is a metabolic disorder and may lead to cognitive dysfunctions.

Objective: The aim of this work is to evaluate the potency of L. seeds ( L.

Phytochemical constituents and protective efficacy of L. leaves extract against thioacetamide-induced hepatic encephalopathy in rats.

Context: Hepatic encephalopathy (HE) is a severe neuropsychiatric syndrome resulting from liver failure.

Objective: To evaluate the protective effect of L. leaves methanol extract against thioacetamide (TAA) induced HE in rats.

mitigates nephrotoxicity induced by carbon tetrachloride in rats regulation oxidative, inflammatory, tubular and glomerular indices.

Context: Carbon tetrachloride (CCl) induces oxidative stress in various tissues by altering antioxidants defense system. Recently, there has been a substantial use of phytotherapy to treat different diseases.

Objective: This study was designed to evaluate the curative effect of (Forssk.

Bioactive compounds and therapeutic role of L. seeds in rheumatoid arthritis rats regulating inflammatory signalling pathways and antagonizing interleukin-1 receptor action.

Context: Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease characterized by aggressive and systematic polyarthritis.

Objective: The present study aimed to isolate and identify the phenolic constituents in L. (Brassicaceae) seeds methanolic extract and evaluates its effect against rheumatoid arthritis in rats referring to the new therapy; interleukin-1 receptor antagonist (IL-1RA).

Downregulation of fibrosis and inflammatory signalling pathways in rats liver aerial parts ethanol extract.

Context: Liver is a vital organ for the detoxification of toxic substances in the body, where fibrosis is the major cause of liver damage. processes many therapeutic applications such as antioxidant, antimicrobial, anticancer and anti-ulcerative agent.

Objective: This study aimed to modulate the fibrosis and inflammatory signalling pathways in carbon tetrachloride (CCl)-induced liver damage in rats treatment with aerial parts ethanol extract (PCEE).

Isolation and characterization of flavonoid compounds from (L.) Vahl and its role as anti-gastro ulcerative agent in rats.

Context: Stomach ulcer is one of the most common gastrointestinal problems in the world.

Objective: This study aimed to isolate flavonoid compounds from methanol extract of the aerial parts of (L.) Vahl.

DNA damage and genetic aberration induced via different sized silver nanoparticles: Therapeutic approaches of Casimiroa edulis and Glycosmis pentaphylla leaves extracts.

Potential of Casimiroa edulis and Glycosmis pentaphylla leaves extracts were investigated against the effect of two different particle sizes of silver nanoparticles induced toxicity in mice. Mice received silver nanoparticles (AgNPs) (100 mg/kg) with 20 and 100 nm for four weeks followed by daily oral dose of extracts (500 mg/kg) for three weeks. C.

An overview on COVID-19: reality and expectation.

Recently, severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), commonly known as coronavirus disease-2019 (COVID-19) has rapidly spread across China and around the world. By the declaration of WHO, COVID-19 outbreak considered as a public health problem of international concern. The aim of this study is to provide a comprehensive view on COVID-19 and the future expectations to control virus progression.

Potential therapeutic effects of antagonizing adenosine A receptor, curcumin and niacin in rotenone-induced Parkinson's disease mice model.

Parkinson's disease (PD) is the second common age-related neurodegenerative disease. It is characterized by control loss of voluntary movements control, resting tremor, postural instability, bradykinesia, and rigidity. The aim of the present work is to evaluate curcumin, niacin, dopaminergic and non-dopaminergic drugs in mice model of Parkinson's disease through behavioral, biochemical, genetic and histopathological observations.

Assessment of titanium dioxide nanoparticles toxicity via oral exposure in mice: effect of dose and particle size.

The aim of the present work is to evaluate the toxicity of titanium dioxide nanoparticles (TiONPs) according to their doses and particle sizes. The effect of five days oral administration of TiONPs (21 and 80 nm) with different doses (50, 250 and 500 mg/kg body weight) was assessed in mice via measurement of oxidative stress markers; glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA) and nitric oxide (NO), liver function indices; aspartate and alanine aminotransferases (AST and ALT), chromosomal aberrations and liver histopathological pattern. The results revealed drastic alterations in all the measured parameters and showed positive correlation with the gradual dose increment.

Chemical composition and protective role of (L.) C.A. Mey. subsp. against gastric ulcer induced by ethanol in rats.

subsp. (Family; Asteraceae) is a medicinal plant used to treat inflammation. The objective of this study is to explore the protective effect of the ethanol extract of subsp.

mitigates gastric ulcer induced by ethanol in rats: role of treatment and auto healing.

Stomach ulcers are the common gastrointestinal disorders worldwide. This study aimed to investigate the therapeutic impact of aerial parts ethanol extract against gastric ulcer in rats. Ulcer was induced by one oral dose of ethanol (0.

Isolation and characterization of the bioactive metabolites from the soil derived fungus .

The aim of the present study was to evaluate different biological activities of fungus (Family Hypocreaceae). isolated for the first time from the cucumber soil (rhizosphere). It was tested as antimicrobial, antioxidant and anticancer agent.

Hepatoprotective evaluation and isolation of the major secondary metabolites from the ethyl acetate extract of liquid culture filtrate of Chaetomium globosum.

The aim of the present study was to evaluate the hepatoprotective activity of ethyl acetate extract of the liquid culture filtrate of Chaetomium globosum fungus (family Chaetomiaceae). Rats were intraperitoneally injected by CCl4 (0.5ml/kg) twice a week for six consecutive weeks.

Melatonin and/or rowatinex attenuate streptozotocin-induced diabetic renal injury in rats.

The study aimed to explore the prophylactic effect of melatonin, rowatinex; a naturally occurring renal drug, and its combination on diabetic nephropathy in type 2 diabetic rats. Diabetes was induced by intraperitoneal injection of a single dose of streptozotocin (50 mg/g body weight). Three days before diabetes induction, rats were daily treated with melatonin, rowatinex and their combination continuously for 8 weeks.

Coenzyme Q10 and niacin mitigate streptozotocin- induced diabetic encephalopathy in a rat model.

Diabetic encephalopathy is an important complication of diabetes characterized by cognitive impairment, neurochemical and structural abnormalities. This study aimed to investigate the effect of coenzyme Q10 (CoQ10) and niacin as well as their combination in the treatment of encephalopathy associated with streptozotocin (STZ)- induced diabetes in rats. Glibenclamide (reference diabetic drug) and donepezil hydrochloride (acetylcholinesterase inhibitor) were also evaluated.

Toxicity of titanium dioxide nanoparticles: Effect of dose and time on biochemical disturbance, oxidative stress and genotoxicity in mice.

The toxic impact of titanium dioxide nanoparticles (TiONPs) on human health is of prime importance owing to their wide uses in many commercial industries. In the present study, the effect of different doses and exposure time durations of TiONPs (21nm) inducing oxidative stress, biochemical disturbance, histological alteration and cytogenetic aberration in mice liver and bone marrow was investigated. Different doses of (TiONPs) (50, 250 and 500mg/kg body weight) were each daily intrapertioneally injected to mice for 7, 14 and 45days.