Publications by authors named "Manaka Shinagawa"
Although endometriosis is primarily benign, it has been identified as a risk factor for endometriosis-associated ovarian cancer (EAOC). Genetic alterations in ARID1A, PTEN, and PIK3CA have been reported in EAOC; however, an appropriate EAOC animal model has yet to be established. Therefore, the present study aimed to create an EAOC mouse model by transplanting uterine pieces from donor mice, in which Arid1a and/or Pten was conditionally knocked out (KO) in Pax8-expressing endometrial cells by the administration of doxycycline (DOX), onto the ovarian surface or peritoneum of recipient mice.
View Article and Find Full Text PDFPurpose: Wasabi is a traditional plant seasoning with an anti-septic function. Recent studies revealed several functions of Wasabi, such as anti-inflammation; however, the anti-tumor effect against endometrial carcinoma (EMC) cells has not been examined. In the present study, we investigated the anti-tumor effect of 6-(methylsulfinyl) hexyl isothiocyanate (6-MITC), a major chemical compound of Wasabi, against various EMC cell lines in vitro and in vivo.
View Article and Find Full Text PDFArticle Synopsis
- The Japan Society of Obstetrics and Gynecology organized "Welcome to OBGYN World!" (WOW!) to address a decline in doctors specializing in obstetrics and gynecology, particularly targeting lower-grade medical students.
- The event was held online to ensure safety during the COVID-19 pandemic and involved participation from 60 of 82 medical schools in Japan, with 285 students and 106 tutors engaged.
- Post-event feedback revealed that a significant majority of participants (97.6%) developed a strong interest in the specialty, while all tutors acknowledged the event's effectiveness in recruitment, leading to plans for an annual WOW! event.
Serous carcinoma (SC) is an aggressive histologic type of endometrial carcinoma (EMC) with a poor prognosis. The development of novel therapeutics for SC is an important issue. PIM1 is a serine/threonine kinase involved in various cellular functions, such as cell cycle progression, apoptosis, and transcriptional activation via the phosphorylation of many target proteins, including MYC.
View Article and Find Full Text PDFClinical characteristics of a novel "Type 3" vasa previa: case series at a single center.
J Matern Fetal Neonatal Med
December 2022
Article Synopsis
- - Vasa previa is a pregnancy complication where fetal blood vessels are positioned near the internal cervical opening, classified into three types: Type 1 connecting a velamentous umbilical cord to the placenta, Type 2 linking lobes of a bilobed placenta, and Type 3, which includes atypical cases with a central or marginal cord insertion.
- - A study over several years found that out of 8,723 deliveries, 14 cases (0.16%) of vasa previa were identified, with 9 being Type 1, none Type 2, and 5 Type 3, indicating that Type 3 is less common.
- - The study highlighted diagnostic challenges, noting that some cases were
Aim: Obstetrics and gynecology (Ob/Gyn) training became compulsory for Japanese physician interns from April 2020 to improve medical competence in treating women's diseases. This study aims to understand the Ob/Gyn training needs of postgraduate year 1-2 physicians (interns) and thereby improve training efficiency.
Methods: This study was administered to interns at Ob/Gyn training facilities from December 2019 to February 2020.