[Tissue reactions to the use of implants manufactured from lactic acid polymers].

Recent literature on the morphological results of the application of polymers produced from lactic acid (polylactides--PLA), contains a plethora of experimental and clinical data on the efficiency and safety of their use for the medico-biological purposes. However, the question on the actual rate of biological disintegration of PLA materials remains unanswered. There are conflicting views on the inflammatory reaction ranging from a complete negation of an inflammatory response to PLA implantation up to the reports describing the expressed aseptic inflammatory reactions caused by presence of this material in tissues.

Local tissue reaction to implantation of biodegradable suture materials.

Morphological changes in tissues adjacent to the implant were studied 1, 2, 6, and 12 months after implantation of biodegradable suture materials (catgut thread, DemeTECH polyfilament thread, and Surgilactin monofilament thread) into subcutaneous fat of rats. Tissue reaction to implantation of different suture materials developed as usual in response to a wound process and to a foreign body. By the end of month 1.

Reaction of rat tissues to implantation of lactic acid-based biodegradable polymer.

Polylactide degradation processes after its implantation into the subcutaneous fat of rats were studied by microscopy. After implantation polylactide was encapsulated in connective tissue. If a fragment of polylactide had sharp edges, injuring the tissue, a thick capsule formed with pronounced inflammatory infiltration and sclerosis of adjacent tissues.

[Morphological tissue changes after the implantation of a biodegradable material on collagen basis].

The objective of this study was to examine the peculiarities of tissue reactions during the degradation of "Collost" bioplastic material on the collagen basis with completely preserved fibrous structure, after its implantation into the bone tissue defect. The defect in bone tissue sized 1-2 mm x 3-5 mm was created in tibial condyle. The study was performed on 24 Wistar rats using light microscopic methods.

[Peculiarities of tissue reactions during resorption of biodegradable suture materials].

The reaction of the surrounding tissues to the implantation of biodegradable suture materials (plain catgut threads, DemeTECH polyglactin 910, Surgilactin--polyglactin 910) into the subcutaneous adipose tissue of rats, was studied using light microscopy 1, 2, 6 and 12 months after grafting. It was shown that the tissue reactions to implantation of different biodegradable suture materials followed the general pattern characteristic of wound healing and foreign body reaction. By the first month of observation, in all the animal groups, the stage of traumatic perifocal inflammation was replaced by a proliferative phase with the new growth of the blood vessels and connective tissue.

Proton dynamics in strong (short) intramolecular H-bond. DFT study of the KH maleate crystal.

The structure, harmonic frequencies, and infrared intensities of the fundamental transitions of potassium hydrogen/deuterium maleate crystals have been computed by the density functional theory with periodic boundary conditions. Different functionals with all-electron Gaussian-type orbital (GTO) basis set have been used. It was found that BLYP/GTO approximation provides the best results for the structural parameters of the KH maleate crystal.

Discovery of 3-acetyl-4-hydroxy-2-pyranone derivatives and their difluoridoborate complexes as a novel class of HIV-1 integrase inhibitors.

HIV-1 integrase (IN) has emerged as an important therapeutic target for anti-HIV drug development. Its uniqueness to the virus and its critical role in the viral life cycle makes IN suitable for selective inhibition. The recent approval of Raltegravir (MK-0518) has created a surge in interest and great optimism in the field.

QTAIM study of strong H-bonds with the O-H...a fragment (A=O, N) in three-dimensional periodical crystals.

The relationship between the d(H...

Synthesis of heterocyclic compounds possessing the 4H-thieno[3,2-b]pyrrole moiety.

A series of novel heterocyclic combinatorial libraries containing 4H-thieno[3,2-b]pyrrole, thieno[2',3':4,5]-pyrrol[1,2-d][1,2,4]triazine and thieno[2',3':4,5]pyrrolo[1,2-a]pyrazine heterocyclic moieties were obtained by parallel solution-phase synthesis. Key steps include different reactions of initial alkyl 4H-thieno[3,2-b]-pyrrole-5-carboxylates, such as alkylation with alkylating agents; transformation of the carboxylate group into different reactive functionalities, followed by reactions with electrophilic species; intramolecular cyclizations; and amide bond formation. Simple manual techniques for parallel reactions were coupled with easy purification procedures to give high-purity final products.

[Problems of health care and decrease of morbidity among workers at the Moscow locomotive repair plant].

The article presents scientific results obtained in Russian Research Center for Railway Hygiene and connected with better organization of treatment, prophylaxis, sanitation and occupational hygiene in Moscow Locomotive Repair Works (MLRW). The authors represent data on transitory disablement morbidity for 1988-1992, which prove efficiency of sanitation approaches put into practice on MLRW. The article contains the main guidelines and prospects of cooperation between medical establishments, MLRW authorities, labor and sport organizations in accomplishment of the program called "Health".