Publications by authors named "Manabu Sen-yo"
Article Synopsis
- EUS-guided biliary drainage (EUS-BD) has shown good results in high-volume centers, but this study investigates its safety and effectiveness in newer centers that recently adopted the procedure.
- The research involved 22 centers from 2017 to 2022, assessing 255 patients and looking at the success and complications of EUS-BD performed by 84 endoscopists.
- The study found a high technical success rate of 91.4% but identified specific risks for failure and complications, including smaller puncture target diameters and moderate ascites, highlighting that the experience level of endoscopists did not significantly affect outcomes.
Background: The best palliation for double obstruction (duodenal obstruction with biliary obstruction) remains unclear. We aimed to compare outcomes of duodenal stenting (DuS) with gastrojejunostomy (GJ) and identify factors associated with survival time and time to recurrent biliary obstruction (TRBO).
Methods: Patients who underwent DuS or GJ combined with biliary stenting for double obstruction due to unresectable malignancy were retrospectively enrolled.
Background/aim: Gemcitabine (GEM) sensitivity can help select the appropriate treatment for pancreatic cancer. We examined the association between HSP27 expression and GEM sensitivity.
Materials And Methods: A total of 19 patients with unresectable pancreatic cancer who underwent endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA) were enrolled and treated with GEM alone.
Postoperative biliary strictures are usually complications of cholecystectomy. Endoscopic plastic stent prosthesis is generally undertaken for treating benign biliary strictures. Recently, fully covered metal stents have been shown to be effective for treating benign distal biliary strictures.
View Article and Find Full Text PDFBackground/aims: Distinguishing pancreatic ductal carcinoma (DC) from other pancreatic masses remains challenging. This study aims at evaluating the efficacy of contrast-enhanced harmonic endoscopic ultrasonography (CEH-EUS) in the diagnosis of DC.
Patients And Methods: Forty-nine patients with solid pancreatic mass lesions underwent CEH-EUS.
Endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA) is a useful and relatively safe tool for the diagnosis and staging of pancreatic cancer. However, there have recently been several reports of tumor seeding after EUS-FNA of adenocarcinomas. A 78-year-old man was admitted to our hospital due to upper gastric pain.
View Article and Find Full Text PDFBackground: Adequate needle size and tissue acquisition techniques for endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) need further elucidation. Moreover, the actual negative pressure and suction forces of FNA needles remain unknown. We evaluated the suction forces of 19-gauge, 22-gauge, and 25-gauge conventional FNA needles and side hole aspiration needles using conventional negative pressure and the slow pull technique.
View Article and Find Full Text PDFDespite the growing evidence demonstrating that is a noteworthy tumor biomarker, little is known about the clinical significance of methylation in human primary pancreatic cancer. In the present study, the association of methylation with clinicopathological characteristics was examined in human primary pancreatic cancer. Primary pancreatic cancer specimens and corresponding healthy pancreatic non-tumorous tissues from 33 patients with pancreatic cancer were used.
View Article and Find Full Text PDFBackground/Purpose. The difficulties of endoscopic retrograde cholangiopancreatography in patients with Billroth II gastrectomy have been reported. We evaluated the usefulness of an anterior oblique-viewing endoscope and a double-balloon enteroscope for endoscopic retrograde cholangiopancreatography in such patients.
View Article and Find Full Text PDFWe review the current situation concerning molecular biological analysis in respect of pancreatic cancer, using specimens obtained by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). K-ras, p53, p16, DPC4/SMAD4, telomerase activity are used for discrimination between tumor-forming pancreatitis and pancreatic cancer. Examination of heat shock protein (HSP) 27, ribonucleotide reductase, and other factors are examined in order to test the sensitivity to Gemcitabin.
View Article and Find Full Text PDFBackground And Purpose: The present study retrospectively analyzed the clinical impact of endoscopic papillectomy on the selection of a treatment strategy for patients with benign-malignant borderline lesions of the major duodenal papilla.
Patients And Methods: Between November 1995 and July 2009, 28 patients were selected for endoscopic papillectomy. The clinical impact of endoscopic papillectomy was assessed.