Publications by authors named "Manabu Kitagaki"

Article Synopsis
  • The study investigates the clinical features of COVID-19 among passengers of the Diamond Princess cruise ship to identify markers for symptom onset and disease progression.
  • It involved a retrospective analysis of 104 patients who were admitted to a hospital in Tokyo with confirmed SARS-CoV-2 infections between February 11 and February 25, 2020.
  • Key findings showed that, at the end of the observation period, 32% remained asymptomatic, 41% had mild symptoms, and 27% developed severe COVID-19, with factors like serum lactate hydrogenase levels taking precedence in identifying symptom severity.
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Femoral artery aneurysms (FAAs) are very rare, and their natural history is not well understood. In this study, we sought to analyze the pathogenesis of inflammatory FAAs in interleukin-1 receptor antagonist-deficient (IL-1Ra(-/-)) B6 mice. Systolic arterial pressures and plasma lipid levels of IL-1Ra(-/-) mice and wild-type (WT) mice did not differ significantly.

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Aim: Tumor necrosis factor receptor 1 (TNFR1) participates importantly in arterial inflammation in genetically altered mice; however it remains undetermined whether a selective TNFR1 antagonist inhibits arterial inflammation and intimal hyperplasia. This study aimed to determine the effect and mechanism of a novel TNFR1 antagonist in the suppression of arterial inflammation.

Methods: We investigated intimal hyperplasia in IL-1 receptor antagonist-deficient mice two weeks after inducing femoral artery injury in an external vascular cuff model.

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Aims: IκBNS regulates a subset of Toll-like receptor (TLR)-dependent genes including interleukin-6 (IL-6) by inhibiting nuclear factor-κB (NF-κB). IL-6 is an inflammatory biomarker for cardiovascular diseases. The aim of this study was to determine whether IκBNS changes arterial inflammation and intimal hyperplasia after vascular injury.

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