Publications by authors named "Manabu Kitagaki"
Article Synopsis
- The study investigates the clinical features of COVID-19 among passengers of the Diamond Princess cruise ship to identify markers for symptom onset and disease progression.
- It involved a retrospective analysis of 104 patients who were admitted to a hospital in Tokyo with confirmed SARS-CoV-2 infections between February 11 and February 25, 2020.
- Key findings showed that, at the end of the observation period, 32% remained asymptomatic, 41% had mild symptoms, and 27% developed severe COVID-19, with factors like serum lactate hydrogenase levels taking precedence in identifying symptom severity.
Femoral artery aneurysms (FAAs) are very rare, and their natural history is not well understood. In this study, we sought to analyze the pathogenesis of inflammatory FAAs in interleukin-1 receptor antagonist-deficient (IL-1Ra(-/-)) B6 mice. Systolic arterial pressures and plasma lipid levels of IL-1Ra(-/-) mice and wild-type (WT) mice did not differ significantly.
View Article and Find Full Text PDFAim: Tumor necrosis factor receptor 1 (TNFR1) participates importantly in arterial inflammation in genetically altered mice; however it remains undetermined whether a selective TNFR1 antagonist inhibits arterial inflammation and intimal hyperplasia. This study aimed to determine the effect and mechanism of a novel TNFR1 antagonist in the suppression of arterial inflammation.
Methods: We investigated intimal hyperplasia in IL-1 receptor antagonist-deficient mice two weeks after inducing femoral artery injury in an external vascular cuff model.
Aims: IκBNS regulates a subset of Toll-like receptor (TLR)-dependent genes including interleukin-6 (IL-6) by inhibiting nuclear factor-κB (NF-κB). IL-6 is an inflammatory biomarker for cardiovascular diseases. The aim of this study was to determine whether IκBNS changes arterial inflammation and intimal hyperplasia after vascular injury.
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