Inhibition of GIP signaling extends lifespan without caloric restriction.

Aims/introduction: Caloric restriction (CR) promotes longevity and exerts anti-aging effects by increasing Sirtuin production and activation. Gastric inhibitory polypeptide (GIP), a gastrointestinal peptide hormone, exerts various effects on pancreatic β-cells and extra-pancreatic tissues. GIP promotes glucose-dependent augmentation of insulin secretion and uptake of nutrients into the adipose tissue.

Food Intake Affects Sperm-Egg Fusion Through the GIP/PSG17 Axis in Mice.

In addition to overeating, starvation also reduces fecundity in mammals. However, little is known about the molecular mechanisms linking food intake to fertility, especially in males. Gastric inhibitory polypeptide (GIP), which is released from intestinal K-cells after meal ingestion, stimulates insulin secretion from pancreatic β-cells through the action of incretin and has several extrapancreatic effects.

[Diabetes treatment with the aim of blood glucose normalization].

Diabetes is the chronic progressive disease and blood glucose control mechanism fails for impaired insulin secretion and increased resistance to insulin action in the skeletal muscle and liver. Unfortunately, cure for diabetes cannot be achieved now, however, it may be possible to control blood glucose at the same level compared with non-diabetic individuals by combining treatment methods. Of course, dietary and exercise therapy are important, and oral hypoglycemic agents and insulin will be used appropriately further, to control not only the average of the blood glucose levels for but also the blood glucose change.