RipAY is a protein from the bacterium Ralstonia solanacearum that can break down the plant's glutathione (GSH) when activated by specific host proteins called thioredoxins (Trxs).
Aave_4606, a protein from another bacterium, Acidovorax citrulli, is similar to RipAY and is also predicted to degrade GSH when stimulated by certain host Trxs.
Research found that Aave_4606's GGCT activity is specifically activated by certain Trxs from Arabidopsis and watermelon, indicating it may play a role in the pathogen's ability to infect its host plants by targeting their cellular defenses.