Publications by authors named "ManYi Wang"

Article Synopsis
  • The study aimed to create a machine learning model to predict the risk of re-fracture in elderly hip fracture patients post-surgery, helping identify those at high risk early on.
  • Clinical data were analyzed using a variety of machine learning algorithms, with models like WeightedEnsemble_L2 showing the best prediction performance in determining independent risk factors such as age and comorbidities.
  • The final model can serve as a valuable tool for healthcare providers, enhancing their ability to assess and manage the risk of re-fractures in elderly patients effectively.
View Article and Find Full Text PDF
Article Synopsis
  • This systematic review evaluated the prevalence of frailty and pre-frailty in older adults with diabetes, analyzing data from 39 studies involving 24,332 participants aged 60 and older.
  • The findings indicated a frailty prevalence of 30.0% and a pre-frailty prevalence of 45.1%, with key risk factors identified as older age, high HbA1c levels, and low physical activity.
  • The study emphasizes the need for healthcare providers to be attentive to frailty and its risk factors during assessments of older adults with diabetes, though there are still gaps in the research on comprehensive risk factors.
View Article and Find Full Text PDF
Article Synopsis
  • 2,4,6-Trichloroanisole (2,4,6-TCA) is a compound with an earthy smell that can pollute drinking water and wine, but research on its toxicity is lacking.
  • Using zebrafish as a model organism, the study found that exposure to 2,4,6-TCA led to significant physical deformities and impairments in heart function, blood flow, and movement due to induced oxidative stress and cell death.
  • The study also identified important gene expression changes related to oxidative stress and apoptosis, highlighting its potential harmful effects and providing valuable insights for assessing risks associated with 2,4,6-TCA exposure.
View Article and Find Full Text PDF

Background: Arthroscopy-assisted closed reduction and percutaneous internal fixation is a minimally invasive technique for medial malleolus fracture treatment. The purpose of the study was to assess the quality and functional outcomes of this technique.

Methods: Seventy-eight patients with combined medial malleolus fractures were treated with arthroscopy-assisted closed reduction and percutaneous screw fixation technique.

View Article and Find Full Text PDF

Developing more robust and productive industrial yeast is crucial for high-efficiency biomanufacturing. However, the challenges posed by the long time required and the low abundance of mutations generated through genomewide evolutionary engineering hinder the development and optimization of desired hosts for industrial applications. To address these issues, we present a novel solution called the Genomewide Evolution-based CRISPR/Cas with Donor-free (GEbCD) system, in which nonhomologous-end-joining (NHEJ) repair can accelerate the acquisition of highly abundant yeast mutants.

View Article and Find Full Text PDF

Object detection is one of the research hotspots in computer vision. However, most existing object detectors struggle with the identification of small targets. Therefore, the paper proposes two modules: the MDFFAM (Multi-Directional Feature Fusion Attention Mechanism) and the LKSPP (Large Kernel Spatial Pyramid Pooling), to enhance the detector's effectiveness in identifying subtle faults on the surface of mechanical equipment.

View Article and Find Full Text PDF

Background: Patients with New York Heart Association (NYHA) grade III chronic heart failure (CHF) present with low capacity for daily activities, severe self-perceived burden, and poor quality of life. Effective nursing interventions may reduce patients' self-perceived burden and improve their quality of life.

Objectives: To explore the effects of an explain-simulate-practice-communicate-support intervention on the self-perceived burden, cardiac function, and activities of daily living (ADL) ability in patients with New York Heart Association grade III chronic heart failure.

View Article and Find Full Text PDF
Article Synopsis
  • The study looks at different types of exercise programs to help patients who have had hip fractures and wants to find out which one works best.
  • After reviewing many clinical trials, it found that resistance exercises (RE) are the most effective for improving hip function, while balance exercises (BE) help with daily activities.
  • The researchers believe that both RE and BE are great options, but they think more careful studies are needed to confirm what they found.
View Article and Find Full Text PDF

Purpose: To evaluate whether the 24-weeks postoperative fracture union rate for the investigational TFNA intramedullary nail was non-inferior compared to the control product PFNA-II.

Methods: The study was a prospective, randomized, single-blind, noninferiority dual-arm study drawing from 9 trauma centers across China, between November 2018 and September 2020, with follow-up measurements at 24 weeks after internal fixation. The full analysis data set (FAS [Intent-to-Treat]) was analyzed and is summarized here.

View Article and Find Full Text PDF

Intelligent mechanical systems are a focused area nowadays. One of the requirements of intelligent mechanical systems is to achieve intelligent fault diagnosis through the real-time acquisition and analysis of data from various sensors installed on mechanical components. In this paper, a new fault diagnosis method is proposed to solve the problems of difficulty in integrating the fault diagnosis algorithm and locating fault parts due to the complexity of modern mechanical systems.

View Article and Find Full Text PDF

Memory CD8T cells participate in the fight against infection and tumorigenesis as well as in autoimmune disease progression because of their efficient and rapid immune response, long-term survival, and continuous differentiation. At each stage of their formation, maintenance, and function, the cell metabolism must be adjusted to match the functional requirements of the specific stage. Notably, enhanced glycolytic metabolism can generate sufficient levels of adenosine triphosphate (ATP) to form memory CD8T cells, countering the view that glycolysis prevents the formation of memory CD8T cells.

View Article and Find Full Text PDF

Many firms in the modern world utilize m-banking systems to communicate with their consumers. The word m-banking refers to a widespread method of providing financial services and localization to customers. Since m-banking is important to both banks and users, it has been included in numerous literary works.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigated the impact of orthogeriatric co-management (OGC) on patients aged 65 and older with hip fractures in China, comparing it to traditional orthopedic care (TOC).
  • Results showed that while OGC patients had shorter waiting times for surgery, there was no significant difference in in-hospital mortality rates or post-surgery mobility outcomes between the two groups.
  • Ultimately, OGC did not significantly improve long-term mobility or reduce mortality, as about half of patients in both groups did not fully return to their pre-injury levels of mobility.
View Article and Find Full Text PDF

Chondroblastoma is one of the uncommon benign bone tumors, particularly when located in the mandibular condyle. Such a location makes its diagnosis difficult when based on only its clinical presentation and radiographic features. Herein the current report presents a case of chondroblastoma of the mandibular condyle: its clinical presentation, radiographic features, and immediate condylar reconstruction after resection.

View Article and Find Full Text PDF

In this study, a new mathematical model was established and validated to forecast and define sensitive targets in the kynurenine pathway (Kynp) in pancreatic adenocarcinoma (PDAC). Using the Panc-1 cell line, genetic profiles of Kynp molecules were tested. qPCR data were implemented in the algorithm programming (fmincon and lsqnonlin function) to estimate 35 parameters of Kynp variables by Matlab 2017b.

View Article and Find Full Text PDF

The mechanisms of inflammation in bone and joint tissue are complex and involve long non‑coding RNAs (lncRNAs), which play an important role in this process. The aim of the present study was to screen out differentially expressed genes in human osteoblasts stimulated by inflammation, and to further explore the mechanisms underlying inflammatory responses and the functional activity of human osteoblasts through bioinformatics methods and in vitro experiments. For this purpose, MG63 cells were stimulated with various concentrations of lipopolysaccharide (LPS) for different periods of time to construct an optimal inflammatory model and RNA sequencing was then performed on these cells.

View Article and Find Full Text PDF

Transplantation of synovial fluid-derived mesenchymal stem cells (SF-MSCs) is a viable therapy for cartilage degeneration of osteoarthritis (OA). But controlling chondrogenic differentiation of the transplanted SF-MSCs in the joints remains a challenge. Kartogenin (KGN) is a small molecule that has been discovered to induce differentiation of SF-MSCs to chondrocytes both in vitro and in vivo.

View Article and Find Full Text PDF

Frozen shoulder is a common shoulder disorder characterized by a gradual increase of pain and a limited range of motion. However, its pathophysiologic mechanisms remain unclear and there is no consensus as to the most effective treatment. The purpose of the study was to investigate the effect of transforming growth factor-β (TGF-β) on fibrosis and inflammatory response of the shoulder joint of rat models and to explore the therapeutic effect of the peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist.

View Article and Find Full Text PDF

Device-free localization (DFL) is a promising technique which could provide localization information for a target without requiring an electronic device. With the development of the smart city and smart transportation, DFL could form part of a basic technique that could be used to track and localize roadside vehicles. In this paper, some algorithms for three-dimensional (3D) DFL for vehicle surveillance are developed, including statistical methods for data, a method for communication link selection, a novel method of communication link weight allocation and some other minor approaches to obtain the location and approximate size of a static vehicle, as a basic technique of moving vehicle detection.

View Article and Find Full Text PDF

This study retrospectively evaluated patients with ankle fracture to compare the prognosis between patients who had primary repair of the superficial deltoid ligament and those who did not. A total of 71 patients with ankle fracture and fracture-dislocation combined with deltoid ligament injury were divided into 2 groups: repair of superficial layer group (33 cases) and nonrepair group (38 cases). For the repair group, patients first underwent open reduction and internal fixation of the lateral malleolus and received a stress test.

View Article and Find Full Text PDF

As the initial part in the development of osteoarthritis (OA), subchondral bone sclerosis has been considered to be initiated by excess mechanical loading and proven to be correlated to other pathological changes. Sclerostin, which is an essential mechanical stress response protein, is encoded by the SOST gene. It is expressed in osteocytes and mature chondrocytes and has been proven to be closely correlated to OA.

View Article and Find Full Text PDF

Introduction: Currently, osteoarthritis (OA) receives global increasing attention because it associates severe joint pain and serious disability. Stem cells intra-articular injection therapy showed a potential therapeutic superiority to reduce OA development and to improve treating outputs. However, the long-term effect of stem cells intra-articular injection on the cartilage regeneration remains unclear.

View Article and Find Full Text PDF

We compared phospholipids (PLs), PL fatty acid (FA) composition, and milk fat globule size and structure in human milk ( = 120) from mothers of full-term and preterm infants during lactation (colostrum, transition, 1 mo, 2 mo, and 3 mo) and 8 brands of infant formulas. The absolute quantification of PLs was analyzed using P NMR spectroscopy. Sphingomyelin was the dominant PLs (35.

View Article and Find Full Text PDF

Cutaneous melanoma is one of the most common malignant skin tumors and advanced melanoma is usually associated with a poor prognosis. In the current study, we demonstrated the tumor suppressing role of epithelial membrane protein-2 (EMP2) by inducing apoptosis in a A375 human melanoma cell line. Mechanistically, the low expression of EMP2 in melanoma is partially due to autophagic protein degradation mediated by the mTOR pathway.

View Article and Find Full Text PDF

Unlabelled: Hip fracture becomes a major public health issue with the growing aging population. This study evaluated a multidisciplinary co-management program for older hip fracture patients and found it significantly improved the best practice indicators. It provided preliminary evidence to support the use of such intervention in hip fracture management.

View Article and Find Full Text PDF