Publications by authors named "Man-Yong Han"
Background: Understanding the trends of anaphylaxis and risk factors associated with its recurrence is essential for the effective management and prevention of this condition.
Objective: This study aimed to analyze the prevalence trends of anaphylaxis and identify risk factors for recurrence, with a focus on the influence of neighborhood deprivation and comorbidities, across all age groups.
Methods: We conducted a retrospective administrative cohort study on anaphylaxis utilizing the National Health Insurance-National Sample Cohort (NHIS-NSC) database in Korea (2002-2019).
Background: Periostin and human chitinase-3-like protein 1 (YKL-40) have been suggested to be involved in the development of airway fibrosis and remodeling. This study aimed to investigate the relationship between serum periostin levels and airway hyperresponsiveness (AHR) and between serum YKL-40 levels and AHR in children with asthma, comparing periostin as a marker for Th2 inflammation and atopy with YKL-40.
Methods: The study involved children aged 6-15 years, comprising 75 with asthma and 29 healthy controls.
Objective: To analyze the complex relationship between socioeconomic status (SES) and neurodevelopmental achievements by investigating the temporal dynamics of these associations from birth to age 6.
Methods: This retrospective cohort study was conducted over 6 years using population-based data from the National Health Insurance Service and integrated data from the National Health Screening Program for Infants and Children. Participants were children born between 2009 and 2011 in Korea without neurodevelopmental delays with potential developmental implications.
Background: Acute bronchiolitis is a common cause of hospitalization during infancy that carries significant morbidity and mortality rates.
Purpose: This study compared the efficacy of different treatment modalities for infants with bronchiolitis in terms of hospital stay and clinical severity scores.
Methods: The PubMed database was searched for relevant studies.
Objective: To evaluate the association between neonatal bronchopulmonary dysplasia and the subsequent development of mental health conditions in children and adolescents.
Study Design: This was a retrospective cohort study, utilizing data from individuals born in South Korea between 2002 and 2005 and followed up until 2021, using the National Health Insurance Database. The cohort included 1 893 314 participants born during that period, with 927 diagnosed with bronchopulmonary dysplasia during the neonatal period (the exposed cohort).
Background/objectives: Understanding the impact of early-life nutritional choices on neurodevelopment in children is a growing area of research. To investigate the association between dietary patterns at multiple timelines and neurodevelopmental outcomes in 6-year-old children.
Subjects/methods: This administrative observational study utilized a merged data from the national health insurance database and the health screening program for children.
Article Synopsis
- Wheezing in early life, often due to viral infections, may lead to an increased risk of autoimmune diseases in children.
- A study in Korea compared 34,959 children with early wheezing to similarly matched controls, finding that those with wheezing had higher incidence rates of autoimmune diseases over 15 years.
- The research highlights specific autoimmune conditions linked to wheezing, indicating a need for further understanding of how early respiratory issues can impact long-term health.
Article Synopsis
- This study analyzes data from over 19,000 Korean children hospitalized for severe respiratory infections and compares them to 191,690 unexposed children to investigate the link between early respiratory viral infections and asthma development.
- Findings indicate that children who experienced severe respiratory infections, including those caused by specific viruses like rhinovirus and influenza, had higher rates of asthma exacerbation and new asthma cases over nearly 8 years of follow-up.
- The research emphasizes that multiple hospitalizations for lower respiratory tract infections significantly increase the risk of asthma complications later in life.
The aim of this study was to explore the epidemiology of cutaneous malignant melanoma (CMM) and the associated risk factors influencing its occurrence and survival among Koreans aged <20 years. In this retrospective cohort investigation, we identified cases of incident melanoma diagnosed in Korean patients aged 0-19 years between 2004 and 2019, utilizing the National Health Insurance database. We assessed annual fluctuations in age-adjusted incidence rates and examined 5-year survival rates based on various factors, including sex, age, income level, sun-exposed sites, and the Charlson Comorbidity Index.
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- The study highlights the risks associated with using first-generation antihistamines in children, especially concerning their potential link to seizure events.
- Researchers analyzed a comprehensive dataset from Korea, focusing on children who experienced seizures from 2002 to 2005, to explore the relationship between antihistamine prescriptions and seizures.
- The findings revealed that a significant number of children who had seizures had also been prescribed antihistamines, particularly those aged 6 months to 6 years, suggesting a need for caution when prescribing these medications.
Article Synopsis
- A study in Korea found that children living in semi-basements, or banjihas, experience higher airway resistance and inflammation compared to those living on higher floors.
- Researchers assessed 575 fifth- and sixth-graders, measuring factors like airway resistance and inflammation while accounting for allergens and pollutants.
- The results showed that despite similar exposure to allergens and pollutants, children in banjihas had worse respiratory health, highlighting the need for better health focus in these living environments.
Background: Community water fluoridation is an effective public health strategy for preventing dental caries, yet. Concerns exist about potential health problems. This study explores associations between tap water fluoride levels and pediatric disease burden, as well as neurodevelopmental outcomes at 6 years of age.
View Article and Find Full Text PDFIntroduction: This study examined the association between sugar-sweetened beverage consumption before the first 24 months of life and attention-deficit/hyperactivity disorder (ADHD).
Methods: A population administrative cohort study was conducted in Korea (2008-2019) using linked national insurance data and a health screening survey. The cohort included 25,305 children in the exposed group with high sugar-sweetened beverage drinks (≥200 mL) and 339,931 in the reference groups (<200 mL) at 24 months of age.
Background: Mycoplasma pneumoniae causes community-acquired pneumonia in children and increases asthma risk, but large studies are lacking.
Objective: To assess the link between M. pneumoniae infection and to asthma exacerbation, in children with allergies, and age of infection impact.
Rotavirus is linked to severe childhood gastroenteritis and neurological complications, but its impact on neurodevelopment remains uncertain. We examined data from 1 420 941 Korean children born between 2009 and 2011, using the Korean National Health Insurance System. We assessed neurodevelopmental outcomes at age 6 years using the validated Korean Developmental Test, covering 6 major domains, with propensity score-based inverse probability weighting including consideration of covariates sex, birth weight, changes in body weight from birth to 4-6 months of age, head circumference at 4-6 months of age, residence at birth, economic status, infant feeding types, and birth year.
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- The study analyzed 9,400 children with ventricular septal defect (VSD) to investigate the risk of developing community-acquired pneumonia (CAP) or asthma.
- Researchers used a Cox proportional hazard model with treatment weighting over a mean follow-up period of 6.67 years, beginning 12 months after birth.
- Results showed that 2,100 CAP admissions occurred in exposed children with an incidence rate of 33.2 per 1000 person-years, compared to 20,109 admissions in unexposed children, leading to a hazard ratio of 1.09, indicating a slightly higher risk for those with VSD.
Article Synopsis
- This study analyzed croup trends in Korean children under 5 from 2002 to 2019, focusing on incidence rates and medication prescriptions using a large population sample.
- Croup-related visits increased significantly, from 16.1 to 98.3 per 10,000 person-years, with consistent trends across various demographics and higher rates when comorbid conditions like asthma were present.
- Treatment patterns shifted, showing a decrease in antibiotics and oxygen use, while nebulized epinephrine and multiple prescriptions rose; primary care centers had longer hospital stays and increased medication use compared to tertiary hospitals.
Article Synopsis
- A study examined the effects of systemic steroid exposure in early infancy on the neurological development of full-term infants with normal birth weight in Korea.
- Using data from 2008-2012, researchers compared a group exposed to steroids in their first three months to a control group and assessed their development at age six using the Korean Development Screening Test (K-DST).
- Findings revealed no significant difference in developmental outcomes between the steroid-exposed group and the control group, suggesting that early steroid exposure does not impair neurodevelopment by age six.
Allergen immunotherapy is regarded as the only disease-modifying treatment option for various allergic conditions, including allergic rhinitis and asthma. Among the routes of administration of allergens, sublingual immunotherapy (SLIT) has gained clinical interest recently, and the prescription of SLIT is increasing among patients with allergies. After 30 years of SLIT use, numerous pieces of evidence supporting its efficacy, safety, and mechanism allows SLIT to be considered as an alternative option to subcutaneous immunotherapy.
View Article and Find Full Text PDFBackground: Atopic dermatitis and autoimmune diseases are highly heritable conditions that may co-occur from an early age.
Methods: The primary study is a national administrative cohort study involving 499,428 children born in 2002, tracked until 2017. Atopic dermatitis was defined as five or more principal diagnoses of atopic dermatitis and two or more topical steroid prescriptions.
Article Synopsis
- The study investigated how exposure to high molecular weight phthalates (HMWP) and low molecular weight phthalates (LMWP) impacts pubertal development in Korean boys and girls aged 10 to 12 years.
- Results showed that higher exposure to HMWP and LMWP was linked to delayed pubertal stages in boys but advanced stages in girls, with boys showing significantly lower testosterone levels at higher HMWP exposure.
- The findings suggest a complex relationship between phthalate exposure and pubertal development, indicating more research is needed to understand its effects, especially in girls.
Background: We investigated the correlation between urine VOC metabolites and airway function in children exposed to anthropogenic volatile organic compounds (VOCs), notable pollutants impacting respiratory health.
Methods: Out of 157 respondents, 141 completed skin prick tests, spirometry, IOS, and provided urine samples following the International Study of Asthma and Allergies in Childhood (ISAAC)-related questions. Allergic sensitization was assessed through skin prick tests, and airway functions were evaluated using spirometry and impulse oscillometry (IOS).
Background: infection is common in the general population and may be followed by immune dysfunction, but links with subsequent autoimmune disease remain inconclusive.
Objective: To estimate the association of infection with the risk of subsequent autoimmune disease.
Methods: This retrospective cohort study examined the medical records of South Korean children from 01/01/2002 to 31/12/2017.
Background: Phthalates and bisphenol A (BPA) are endocrine-disrupting chemicals and may cause immunological disorders in children. Therefore, according to the region, we investigated urinary phthalates and BPA levels and the relationship between urinary phthalate, aeroallergen sensitization, and eosinophil count during the coronavirus disease 2019 pandemic.
Methods: In total, 203 schoolchildren (134 residential and 69 industrial) aged 7-10 years were enrolled between July 2021 and July 2022.