Publications by authors named "Man-Di Wu"
Aims/introduction: Type 2 diabetes triggers an inflammatory response that can damage red blood cells. M2 macrophages have inhibitory effects on inflammation, and play an important role in tissue damage repair and fibrosis. Autologous blood transfusion has the potential to inhibit red blood cell damage by mediating macrophage polarization.
View Article and Find Full Text PDFBackground: To study the link between macrophage polarization, PUM1/Cripto-1 pathway and ferroptosis in the allogeneic blood transfusion setting.
Methods: This is an exploratory research. The purpose of this study was to investigate the effect of PUM1/Cripto-1 pathway on ferroptosis by regulating macrophage polarization in allogeneic blood transfused mice.
Article Synopsis
- This study investigates how Cripto-1 and macrophage polarization affect immune responses after allogeneic transfusions using a mouse model.
- Researchers conducted both in vitro and in vivo experiments to examine the role of miR-449a on the PI3K/AKT/NF-κB signaling pathway and its downstream effects.
- Findings indicate that inhibiting miR-449a increases Cripto-1 expression, while allogeneic transfusion decreases Cripto-1 levels, leading to altered macrophage polarization and impacting the body's immune response.