The impact of rumen microbial composition on apparent digestibility, rumen fermentation and metabolism in Sanhe cows and Holstein cows of different parities under identical dietary conditions.

Previous studies have discussed the association between serum metabolism and lactation performance among Sanhe and Holstein cows of different parities and found that the metabolic profiles of these two breeds vary differently with parity. Since the rumen is the central organ for nutrient absorption and production transformation in dairy cows, it remains unknown whether the differences observed under the same dietary conditions are related to the structure of the rumen microbiome. This study measured the apparent digestibility and rumen fermentation parameters of Sanhe cows (S1/S2/S3/S4) and Holstein cows (H1/H2/H3/H4) across four parities and generated a comprehensive rumen microbiome dataset using high-throughput sequencing technology.

Inhibition of macrophage inflammasome assembly and pyroptosis with GC-1 ameliorates acute lung injury.

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a critical syndrome with a mortality rate of up to 40%, and it is characterized by a prominent inflammatory cascade. The inflammasome and pyroptosis play crucial regulatory roles in regulating various inflammatory-related diseases by serving as pivotal signaling platforms for inflammatory responses and mediating the release of substantial quantities of inflammatory factors. Our previous studies confirmed that GC-1, a clinical-stage thyroid hormone analog, effectively mitigated pulmonary fibrosis by restoring mitochondrial function in epithelial cells.

Strigolactones, ROS and ABA Regulate Systemic Salt-Tolerance Priming Signals Between Dodder-Connected Tobacco Plants.

The parasitic plants dodders (Cuscuta spp., Convolvulaceae) can often simultaneously parasitize two or more neighbouring hosts, forming dodder-connected plant clusters. In a dodder-connected plant cluster, salt-induced systemic priming signals are transferred from the salt-stressed host (signal donor, SD) to the other host (signal receiver, SR) through dodder and prime the SR plants for enhanced salt tolerance, but what signalling pathways regulate the dodder-mediated interplant priming signals remain unclear.

Clinical effect analysis of timed strengthening moxibustion combined with continuing nursing on symptoms of qi deficiency and blood stasis type.

This study is based on the theory of meridian flow and aims to evaluate the clinical effect of timed strengthened moxibustion combined with continuous nursing on patients with shoulder-hand syndrome after stroke accompany with qi deficiency and blood stasis. This is a retrospective study. This study included 60 patients who visited the acupuncture and moxibustion Department of the local college of Chinese medicine from January 2022 to January 2023.

UDP-Glycosyltransferases Engineering Coupled with UDPG Regeneration Facilitate the Efficient Conversion of Mogroside V.

Mogroside V is a triterpene, a natural high-intensity sweetener, isolated from the fruits of . Selective glycosylation of mogrol is a feasible approach for the biosynthesis of mogroside V. In this study, glycosyltransferase UGTM1 and UGTM2 were engineered to UGTM1-3 and UGTM2-4, which selectively and directly transfer glucose from UDPG to 3'-hydroxyl and 24'-hydroxyl groups and their branch chains of the mogrol moiety for the biosynthesis of mogroside V.

Reduced SMEK1 regulates trophoblast migration and invasion in fetal growth restriction.

Introduction: Fetal growth restriction (FGR) is a significant pregnancy condition characterized by the fetus failing to attain its full genetic growth potential. FGR is primarily ascribed to defective placentation, owing to impaired trophoblast cellular function. The objective of this research is to elucidate the pathogenic functions of suppressor of Mek1 (SMEK1) in FGR.

A Comparative Study on the Progression of Neuroendocrine Carcinomas and Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms.

Introduction: The prognostic differences between neuroendocrine carcinoma (NEC) and mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) remain unclear.

Methods: This study aimed to compare the prognostic outcomes of NEC and MiNEN by analyzing the clinicopathological features of these diseases and exploring factors affecting progression after radical surgery. Additionally, we employed whole-exome sequencing to investigate the molecular mechanisms influencing the prognosis of both conditions.

Ginsenoside Rh2 promotes cell apoptosis in T-cell acute lymphocytic leukaemia by MAPK and PI3K/AKT signalling pathways.

T-cell acute lymphoblastic leukaemia (T-ALL) is a common childhood malignant tumour, which has poor prognosis and high recurrence rate. Ginsenoside Rh2 (GRh2), a bioactive ingredient of has significant anti-tumour effect. In this study, we found that gene expressions of Jurkat cells were significantly changed in the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT) signalling pathways after 35 µm GRh2 treatment, involving in JUN, PIEN, AKT3 and MAPK8IP2.

Biomimetic Materials to Fabricate Artificial Cells.

As the foundation of life, a cell is generally considered an advanced microreactor with a complicated structure and function. Undeniably, this fascinating complexity motivates scientists to try to extricate themselves from natural living matter and work toward rebuilding artificial cells . Driven by synthetic biology and bionic technology, the research of artificial cells has gradually become a subclass.

MicroRNA399s and strigolactones mediate systemic phosphate signaling between dodder-connected host plants and control association of host plants with rhizosphere microbes.

A dodder (Cuscuta) often simultaneously parasitizes two or more adjacent hosts. Phosphate (Pi) deficiency is a common stress for plants, and plants often interact with soil microbes, including arbuscular mycorrhizal fungi (AMF), to cope with Pi stress. Little is known about whether dodder transmits Pi deficiency-induced systemic signals between different hosts.

Shenmai injection improves lipid metabolism in post-myocardial infarction heart failure based on network pharmacology and experimental validation.

Background: Shenmai injection (SMI), a traditional Chinese medicine formulation derived from the herbal decoction Shenmai Yin, is widely used in treating cardiovascular disorders. This study extensively investigated the effects and mechanisms of action of SMI on lipid metabolism in post-myocardial infarction heart failure (pMIHF).

Methods: Network pharmacology was employed to predict the key targets and associated pathways involved in lipid metabolism for potential SMI treatments in post-myocardial infarction heart failure (pMIHF).

Fabrication, characterization and simulated gastrointestinal digestion of sea buckthorn pulp oil microcapsule: effect of wall material and interfacial bilayer stabilization.

Background: Sea buckthorn (Hippophae rhamnoides L.) pulp oil is rich in functional components; however, low water solubility and stability limit its applications. This study fabricated sea buckthorn pulp oil microcapsules using whey protein isolate (WPI), soy protein isolate (SPI), sodium caseinate (NaCN), gum arabic (GA), starch sodium octenylsuccinate (OSAS) and SPI mixed with chitosan (CHI).

Daratumumab, bortezomib, melphalan, and prednisone versus bortezomib, melphalan, and prednisone alone in transplant-ineligible Asian patients with newly diagnosed multiple myeloma: final analysis of the phase 3 OCTANS Study.

The superiority and tolerability of daratumumab plus bortezomib/melphalan/prednisone (D-VMP) versus bortezomib/melphalan/prednisone (VMP) in transplant-ineligible patients with newly diagnosed multiple myeloma (NDMM) was previously described in the global phase 3 ALCYONE study. The primary analysis of the phase 3 OCTANS study further demonstrated the superiority and tolerability of D-VMP (n = 144) versus VMP (n = 71) in transplant-ineligible Asian patients with NDMM. The current analysis describes the final efficacy and safety outcomes for D-VMP versus VMP in OCTANS, with a follow-up of > 3 years.

Effect of ultrasound-assisted pH-shifting treatment on the physicochemical properties of melon seed protein.

Melon seeds have received considerable attention in recent years because of their high protein content, but they have not yet been fully used. The modification of melon seed protein (MSP) using ultrasound-assisted pH-shifting treatment was investigated in this study by analyzing structural characteristics and functional properties. The particle size, free sulfhydryl content, surface hydrophobicity, solubility, secondary structure, water-holding capacity, oil-holding capacity, emulsification activity index, and emulsification stability index of MSP were determined.

Tofacitinib versus thalidomide for mucocutaneous lesions of systemic lupus erythematosus: A real-world CSTAR cohort study XXVII.

Objective: Thalidomide is an effective medication for refractory mucocutaneous lesions of systemic lupus erythematosus (SLE) and can treat arthritis in some autoimmune diseases, but it has some adverse reactions. Recently, the effectiveness of tofacitinib in treating mucocutaneous lesions of SLE has been reported. We aimed to compare the efficacy and safety of tofacitinib with thalidomide in treating mucocutaneous and musculoskeletal lesions in patients with SLE.

Ultrafast Conversion of Water and Oxygen Molecules With Dissociation of Hydrogen Bonding Effect to Achieve Extra-High Energy Efficiency of Secondary Metal-Air Batteries.

Metal-air secondary batteries with ultrahigh specific energies have received vast attention and are considered new promising energy storage. The slow redox reactions between oxygen-water molecules lead to low energy efficiency (55-71%) and limited applications. Herein, it is proposed that the MIL-68(In)-derived porous carbon nanotube supports the CoNiFeP heteroconjugated alloy catalyst with an overboiling point electrolyte to achieve the ultrahigh oxidation rate of water molecules.

Hemin regulates platelet clearance in hemolytic disease by binding to GPIbα.

Hemolysis is associated with thrombosis and vascular dysfunction, which are the pathological components of many diseases. Hemolytic products, including hemoglobin and hemin, activate platelets (PLT). Despite its activation, the effect of hemolysis on platelet clearance remains unclear, It is critical to maintain a normal platelet count and ensure that circulating platelets are functionally viable.

Current Advances in Nanomaterials Affecting Functions and Morphology of Platelets.

Nanomaterials have been extensively used in the biomedical field due to their unique physical and chemical properties. They promise wide applications in the diagnosis, prevention, and treatment of diseases. Nanodrugs are generally transported to target tissues or organs by coupling targeting molecules or enhanced permeability and retention effect (EPR) passively.

Nickel foam-loaded Co-MOF@TiO/MoS as electrode materials for dual-function devices for glucose detection and hydrogen evolution.

Dual-functional nanomaterial electrodes have the capability to satisfy the requirements for both sweat analysis and the hydrogen evolution reaction (HER), thereby enabling the integration of electrochemical sensing and hydrogen production. In this study, ZIF-67 cubes are synthesized on nickel foam (NF), while TiO is obtained through an annealing process. Subsequently, the ZIF-67@TiO/MoS nanocomposite is fabricated on nickel foam via a hydrothermal method.

Low-temperature subcritical water dechlorination composites of waste PVC/coal fly ash with powerful sensing activity for chemiluminescent detection of acetamiprid and imidacloprid.

Pesticide residues in agricultural products are serious threat to people's health. Real-time monitoring of pesticides residues in the environment and agricultural products posed challenges to sustainable methods with high analytical performance for pesticide detection. Herein, waste PVC/coal fly ash (the mass ratio of PVC and coal fly ash was 4:1) was dechlorinated in subcritical water at low temperature to achieve nearly 100 % dechlorination of PVC and obtain carbon-based composite materials (CM-Fe/Al/Si-dPVC) with strong sening activity.