Publications by authors named "Man Huang"

Background: The relationship of the first-trimester triglyceride-glucose (TyG) index with GDM (gestational diabetes mellitus) and other adverse pregnancy outcomes has yet to be fully understood. This study aims to investigate the relationship between the first-trimester TyG index and the risk of adverse pregnancy outcomes in pregnant women.

Methods: The data for the retrospective cohort study were derived from the Maternal and Child Health Hospital of Longgang District, Shenzhen, China.

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Background: Extracorporeal membrane oxygenation (ECMO) as rescue therapy for cardiogenic shock (CS) is highly dependent on timeliness and medical resources.

Objectives: Aimed to assess ECMO management and outcomes in adult patients with CS in terms of on- and after-hour ECMO initiation from a national ECMO registry.

Methods: Adult patients diagnosed with CS and those who received ECMO were enrolled in the study.

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Background: Extracorporeal membrane oxygenation (ECMO) provides effective support for respiratory and circulatory functions and stands as an essential means in the management of life-threatening conditions. This study aimed to evaluate the safety and efficacy of a novel ECMO system in awake sheep models across various support durations.

Methods: Ten healthy Hu sheep were divided into venovenous (VV) and venoarterial (VA) groups, further categorized into short, medium, and long-term observation subgroups.

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Background: On June 13, 2020, an explosion involving a liquefied natural gas (LNG) tanker truck occurred in eastern China. Fifteen patients with extremely severe burns (referred to as "June 13" patients) were treated in the burn-intensive care unit (ICU) joint ward within the general ICU.

Methods: A multidisciplinary treatment team comprising 129 doctors, 126 nurses, and 165 auxiliary staff members was assembled.

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Fatty acids (FAs) are essential building blocks for all the domains of life, of which bacterial de novo synthesis, called type II FA synthesis (FAS II), is energetically expensive. The recycling of exogenous FAs (eFAs) partially relieves the FAS II demand and, therefore, compromises the efficacy of FAS II-directed antimicrobials. The versatile acyl-acyl carrier protein (ACP) synthetase, AasS, enables bacterial channeling of diverse eFA nutrients through holo-ACP, an activated form of ACP.

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  • The excavation of large tunnel portals can lead to significant engineering challenges, necessitating a thorough understanding of construction mechanics and careful scheme selection.
  • In analyzing a six-lane expressway tunnel in Southwest China, three excavation methods were compared: the three-bench seven-step method, the central diaphragm method (CDM), and the double side drift method (DSDM).
  • Results showed that asymmetrical loads affected rock deformation, with both CDM and DSDM providing better stability and less deformation by adapting the excavation sequence for optimal results.
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The covalently attached cofactor biotin plays pivotal roles in central metabolism. The top-priority ESKAPE-type pathogens, and , constitute a public health challenge of global concern. Despite the fact that the late step of biotin synthesis is a validated anti-ESKAPE drug target, the primary stage remains fragmentarily understood.

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The histone locus body (HLB) is a membraneless organelle that determines the transcription of replication-dependent histones. However, the mechanisms underlying the appropriate formation of the HLB in the nucleus but not in the cytoplasm remain unknown. HLB formation is dependent on the scaffold protein NPAT.

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sequence type (ST) 88, encompassing both methicillin-resistant (MRSA) and methicillin-sensitive (MSSA) phenotypes, is globally prevalent and commonly associated with skin and soft tissue infections. Despite its widespread occurrence, comprehensive genomic studies on this clone remain scarce. In this study, we performed detailed genomic analyses on 130 ST88 isolates derived from severe bloodstream infections alongside 275 publicly available ST88 sequences.

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  • The electrocatalytic reduction of nitrate to ammonia presents a sustainable alternative to the Haber-Bosch process, facing challenges like slow reaction rates and competing reactions.
  • A titanium hydride electrocatalyst was created through electrochemical processes, achieving impressive ammonia production rates and efficiency at specific operational conditions.
  • The research shows that the unique properties of lattice hydrogen in titanium hydride enhance its catalytic activity and stability, suggesting a promising approach for designing metal hydride catalysts for sustainable ammonia synthesis.
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Objectives: Extracorporeal membrane oxygenation (ECMO) has become an important life support technique during lung transplantation. We aimed to develop a rat model for lung transplantation using venoarterial (VA) ECMO support.

Methods: Adult male Sprague-Dawley rats weighing 400 to 450 g were used in this study.

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  • - The text details a new surgical technique for fixing defects in the donor's anterior left atrial wall during lung transplantation by using a rotated flap from the posterior atrial wall.
  • - This method efficiently addresses common anterior wall defects while reducing the time required for atrial cuff anastomosis and maintains normal blood flow post-surgery.
  • - Overall, the technique enhances the effective use of donor lungs, showing improved pulmonary function and no significant risk of complications compared to traditional methods.
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  • HER2-low breast cancer is a unique subgroup that presents distinct clinical challenges, particularly regarding the relationship between Ki67 index changes and patient prognosis.
  • A retrospective study involving 790 patients analyzed the impact of Ki67 index alterations after neoadjuvant chemotherapy (NAC) on disease-free survival (DFS), revealing that δKi67 values did not correlate significantly with survival but indicated some prognostic advantages.
  • The findings suggest that HER2-low patients with post-NAC δKi67 values below a certain threshold have better outcomes than those with higher values and also perform better than HER2-zero patients, indicating the potential for more tailored treatment approaches.
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Dependable and sensitive glucose (Glu) testing in foodstuff and blood serum is highly desirable to prevent and treat diabetes. Electrochemical quantification of Glu has attracted great interests due to the advantages, including simple operation, higher sensitivity, easy miniaturization, ease of on-site and wearable detection as well as fast response. High costs and environmental dependence of enzymes pose a challenge to the electrochemical enzymatic biosensors.

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  • The study investigates the relationship between secreted phosphoprotein 1 (SPP1), idiopathic pulmonary fibrosis (IPF), and non-small cell lung cancer (NSCLC), noting that SPP1 is overexpressed in both conditions.
  • Researchers found that SPP1 contributes to the proliferation of IPF fibroblasts and influences the progression of NSCLC by activating key cellular pathways.
  • Overall, the results indicate that SPP1 may play a crucial role in the pathogenesis of IPF and NSCLC, suggesting it could be a potential target for therapeutic interventions.
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  • A study looked at a way to help prevent severe pain after lung transplant surgery using a method called the serratus anterior plane block (SAPB).
  • They monitored 14 patients who received this treatment to see how well it worked and if it was safe.
  • The results showed that most patients experienced good pain control without any major issues, but there were some limitations in how the study was conducted.
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The aim of this study was to investigate whether the protective effect of 2-deoxyglucose (2-DG) on lung ischemia/reperfusion (I/R) injury is mediated by inhibiting nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)-mediated pyroptosis in rats. Male Sprague-Dawley rats were randomly divided into control group, 2-DG group, lung I/R injury group (I/R group) and 2-DG+I/R group. 2-DG (0.

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Purpose: This study aims to devise and assess an automated measurement framework for lumbar pedicle screw parameters leveraging preoperative computed tomography (CT) scans and a deep learning algorithm.

Methods: A deep learning model was constructed employing a dataset comprising 1410 axial preoperative CT images of lumbar pedicles sourced from 282 patients. The model was trained to predict several screw parameters, including the axial angle and width of pedicles, the length of pedicle screw paths, and the interpedicular distance.

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Against the backdrop of escalating environmental pollution and resource depletion induced by traditional agricultural industry development, the imperative for agricultural efficiency and ecologically friendly practices has become pivotal for global agricultural sustainability. In the digital era, rural digitalization has substantially amplified agricultural production efficiency while notably reducing environmental pollution. This study is based on panel data from 1602 counties in China spanning from 2011 to 2020, measuring the levels of rural digitalization and agricultural green total factor productivity (AGTFP) across these counties, empirically examining their dynamic correlation.

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Microsphere-based embolic agents have gained prominence in transarterial embolization (TAE) treatment, a critical minimally invasive therapy widely applied for a variety of diseases such as hypervascular tumors and acute bleeding. However, the development of microspheres with long-term, real-time, and repeated X-ray imaging as well as ultrasound imaging remains challenging. In this study, emulsion-based dual-modal imaging microbeads with a unique internal multi-interface structure is developed for TAE treatment.

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Background: Sepsis is a severe and potentially life-threatening condition characterized by a dysregulated host response and organ dysfunction. The causal relationship between intestinal microbiota and sepsis is unclear.

Methods: A two-sample Mendelian randomization (MR) study was performed to proxy the causal association between gut microbiota and sepsis.

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  • Scientists created a tool called U-AKIpredTM to help doctors predict if critically ill patients will get acute kidney injury (AKI) within 12 hours, using urine tests.
  • They studied 680 patients, and found that 12 specific markers in urine, especially three main ones, were great for this prediction.
  • The tool showed really good results, helping doctors make decisions to prevent or treat AKI more effectively, and it can be accessed online for easy use.
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Antimicrobial resistance is an ongoing "one health" challenge of global concern. The acyl-ACP synthetase (termed AasS) of the zoonotic pathogen Vibrio harveyi recycles exogenous fatty acid (eFA), bypassing the requirement of type II fatty acid synthesis (FAS II), a druggable pathway. A growing body of bacterial AasS-type isoenzymes compromises the clinical efficacy of FAS II-directed antimicrobials, like cerulenin.

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  • Transarterial chemoembolization (TACE) is a treatment for unresectable primary liver cancer, but it struggles with poor long-term drug release and effectiveness.
  • Researchers created gelatin-based microembolic agents that use nanosized poly(acrylic acid) to improve drug loading and release patterns, allowing for sustained treatment over two months.
  • The new microembolics showed excellent delivery and tumor-killing abilities in animal models while causing minimal inflammation and permanent vessel embolization after degradation, offering a promising strategy for enhancing local chemotherapy outcomes.
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