Zh Nevrol Psikhiatr Im S S Korsakova
April 1995
Serotonin antibodies (SAb) were found in the blood sera of middle-aged and elderly parkinsonian patients. The incidence of Sab in young and middle-aged healthy subjects was less, but increasing with age. Injected into the rabbit caudate nuclei, Sab suppressed the main pathogenetic mechanism of parkinsonian syndrome, the generator of pathologically enhanced excitation (GPEE) and parkinsonian symptoms induced by the MPP injection into substantia nigra.
View Article and Find Full Text PDFZh Nevrol Psikhiatr Im S S Korsakova
May 1994
Dopamine antibodies (DAb) were found in the blood serum of parkinsonian patients, middle-aged and elderly, but not young. There was a correlation between the DAb incidence and dominant symptom in the middle-aged and elderly patients and between DAb and anginal parkinsonism in the elderly patients. DAb-binding serum gamma-globulins of parkinsonian patients injected into rat caudate nuclei induced the pathogenetic mechanism of Parkinson's syndrome (the generator of pathologically enhanced excitation-GPEE) in this brain part and evoked main parkinsonian symptoms (oligokinesia, rigidity and tremor).
View Article and Find Full Text PDFAn analysis is presented of age-related changes of the nervous system in the course of aging and their role in the development and course of age-dependent diseases, primarily, atherosclerosis, arterial hypertension, parkinsonism, osteochondrosis etc. in the elderly and old. Practical physicians have to pay attention to the peculiarities of clinical symptomatology, diagnosis, treatment and secondary prophylaxis of nervous system diseases in the elderly and old.
View Article and Find Full Text PDFL-DOPA and dopamine (DA) binding antibodies were found in the blood serum of Parkinsonian patients and middle-aged and elderly normal persons. DA-binding serum gamma-globulins of parkinsonian patients injected into rat caudate nuclei induced the pathogenetic mechanism of Parkinson's syndrome (generator of pathologically enhanced excitation) in these brain part and evoked main parkinsonian symptoms (oligokinesia, rigidity, tremor). The serum gamma-globulins of Parkinsonian patients without Da-antibodies caused less pronounced EEG disturbances.
View Article and Find Full Text PDFFiziol Zh (1978)
February 1991
This paper deals with the functional state of the brain and its descending regulatory influences on the brain stem-spinal formations in the elderly. The role of changes revealed in the formation of the clinical syndrome of age-related extrapyramidal insufficiency (EPI) as a risk factor of Parkinson's disease, has been shown. 274 apparently healthy subjects aged from 20 to 102 and 136 patients with early stages of Parkinson's disease were examined.
View Article and Find Full Text PDFComplex clinico-physiological examinations was performed in 300 patients of middle and old ages with early and pronounced dyscirculatory encephalopathy of atherosclerotic and, in most cases, hypertensive etiologies. The cerebral hemodynamics was found to be relatively independent of the central one in patients with early atherosclerotic encephalopathy; the level of the systemic circulation and that of the median regional cerebral flow were found to correlate in early and advanced hypertensive encephalopathy cases. The cerebral function was shown to be more associated with the cerebral flow in the early encephalopathy in elderly patients than in middle-aged ones.
View Article and Find Full Text PDFThe authors report results of a clinico-physiological study of the efficacy of a vasoactive agent sermion in patients with initial atherosclerotic encephalopathy indicating a positive effect of course treatment with this agent on the main clinical manifestations of the disease, pulse blood filling, bioelectric activity of the brain, psychomotor rate, mental working capacity, mnemonic function. Considering the established age-related differences in the efficacy of the agent, it is expedient to recommend sermion for long-term employment in the elderly. One should be cautious in instituting the drug in persons suffering of raised intraocular pressure.
View Article and Find Full Text PDFZh Nevropatol Psikhiatr Im S S Korsakova
June 1989
Combined clinicophysiological investigation was performed in IDE (195 patients) in order to assess the degree of cerebral circulation disorders and their impact on the levels of brain functional activity. The informative values of several quantitative indices of brain hemodynamics and neurodynamics were assessed with respect to the patients' age. Single administration and full course of cavinton and sermion (nicergoline) were effective as judged by cerebral circulation studies (133Xe clearance), brain bioelectric activity (EEG frequency integration analysis, visual evoked potentials).
View Article and Find Full Text PDFThe article presents clinico-hemodynamic characteristics of 81 patients with initial disordered-circulatory atherosclerotic encephalopathy (33 aged 45-59 years and 48 aged 60-74 years) and of 65 patients with hypertensive encephalopathy (32 aged 45-59 years and 33 aged 60-74 years). Fifty-six normal subjects served as controls. The findings confirm the role of abnormalities at various functional levels of the circulatory system in the pathogenesis of cerebral vascular insufficiency at early stages of the disease.
View Article and Find Full Text PDFZh Nevropatol Psikhiatr Im S S Korsakova
December 1987
Parameters of the cerebral and systemic circulation were studied with the help of rheoencephalography in 119 patients with initial circulatory encephalopathy secondary to atherosclerosis (50 patients aged 45 to 59 years; 69, 60 to 74 years). Fifty-six healthy subjects served as a control group. The data obtained confirm the development of combined cardio-cerebrovascular insufficiency already at the initial stage of the disease and indicate the necessity of a comprehensive approach to the assessment of the function of two circulatory systems at an early stage of cerebrovascular pathology.
View Article and Find Full Text PDFZh Nevropatol Psikhiatr Im S S Korsakova
February 1988
Vestn Akad Med Nauk SSSR
December 1986
Zh Nevropatol Psikhiatr Im S S Korsakova
January 1986
On the basis of a comprehensive experimental-psychological examination of clinically healthy people of advanced age groups, the authors have established the main regularities of changes in mental activity with age. It is demonstrated that deterioration of memory, attention and apractognostic processes is largely due to a reduction in the tone of the brain cortex. The normative parameters of the functional mobility and mental working ability are presented for people aged 20 to 100 years.
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