Publications by authors named "Mamta Kumawat"
Nanomaterials with enzyme-like properties are known as 'nanozymes'. Nanozymes are preferred over natural enzymes due to their nanoscale characteristics and ease of tailoring of their physicochemical properties such as size, structure, composition, surface chemistry, crystal planes, oxygen vacancy, and surface valence state. Interestingly, nanozymes can be precisely controlled to improve their catalytic ability, stability, and specificity which is unattainable by natural enzymes.
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- Nanomaterials can evade the immune system, altering immunological responses and potentially causing inflammation due to their unique physical and chemical properties.
- The size, shape, composition, surface charge, and adsorbed molecules on nanomaterials significantly influence how immune cells respond to these materials.
- The review focuses on the characteristics of engineered nanomaterials, their effects on immune responses, biocompatibility, safety concerns, and future developments in optimizing their application in immunomodulation.
Infection, trauma, and autoimmunity trigger tissue inflammation, often leading to pain and loss of function. Therefore, approaches to control inflammation based on nanotechnology principles are being developed in addition to available methods. The metal-based nanoparticles are particularly attractive due to the ease of synthesis, control over physicochemical properties, and facile surface modification with different types of molecules.
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- Smart design of nanoparticles with different surfaces could lead to new biomedical applications, moving away from toxic chemical synthesis methods.
- The synthesis of gold nanoparticles using curcumin, along with a surface coating of isoniazid, tyrosine, and quercetin, results in nanoparticles that mimic peroxidase and are effective at scavenging free radicals.
- These engineered nanoparticles demonstrate good compatibility with red blood cells and mouse macrophages, and they help reduce harmful pro-inflammatory cytokines, suggesting their potential for safe use in nanomedicine.
Objectives This study was conducted to evaluate the feasibility of robotic hysterectomy for benign indications in patients with small size (<14 weeks) versus large size (>14 weeks) uterus. Methods This prospective study was conducted in a single centre from August 2018 to January 2020 in the Department of Obstetrics and Gynecology at All India Institute of Medical Sciences, Rishikesh (Uttarakhand). Surgical outcomes of 216 patients who underwent a robotic hysterectomy in our institution for benign indications were analysed.
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