Persistent Organic Pollutants and Suspended Particulate Matter in Snow of Eastern Siberia in 2009-2023: Temporal Trends and Effects of Meteorological Factors and Recultivation Activities at Former Industrial Area.

Suspended particulate matter (SPM), polychlorinated biphenyls (PCBs), and organochlorine pesticides (OCP) were studied in the snow cover at urban and suburban localities in the Irkutsk region, Eastern Siberia for their temporal variations in 2009-2023, daily deposition fluxes (DDFs), and effects of some meteorological factors, as well as the effects of different technogenic activities in the industrial area of the former organochlorine enterprises of Usol'ekhimprom. SPM loads at both stations were found to be at a low level of pollution. The levels of HCB, α + γ-HCH, and ∑,'-DDX were lower than Russian maximum permissible levels (MPLs) in drinking water, groundwater, and surface water for household drinking and cultural purposes.

Hybrid protein-peptide system for the selective pH-dependent binding and photodynamic ablation of cancer cells.

Creating new tools for the early diagnosis and treatment of cancer is one of the most important and intensively developing areas of modern medicine. Currently, photodynamic cancer therapy (PDT) is attracting increasing attention as a unique modality of minimally invasive treatment and due to the absence of acquired resistance. However, PDT is associated with undesirable activities, such as non-specific photodynamic effects of sunlight on healthy tissues.

FUS RRM regulates poly(ADP-ribose) levels after transcriptional arrest and PARP-1 activation on DNA damage.

PARP-1 activation at DNA damage sites leads to the synthesis of long poly(ADP-ribose) (PAR) chains, which serve as a signal for DNA repair. Here we show that FUS, an RNA-binding protein, is specifically directed to PAR through its RNA recognition motif (RRM) to increase PAR synthesis by PARP-1 in HeLa cells after genotoxic stress. Using a structural approach, we also identify specific residues located in the FUS RRM, which can be PARylated by PARP-1 to control the level of PAR synthesis.

Novel Catalyst Composites of Ni- and Co-Based Nanoparticles Supported on Inorganic Oxides for Fatty Acid Hydrogenations.

In the quest to develop nanometrically defined catalytic systems for applications in the catalytic valorization of agri-food wastes, small Ni-based nanoparticles supported on inorganic solid supports have been prepared by decomposition of organometallic precursors in refluxing ethanol under H atmosphere, in the presence of supports exhibiting insulating or semi-conductor properties, such as MgAlO and TiO, respectively. The efficiency of the as-prepared Ni-based nanocomposites has been evaluated towards the hydrogenation of unsaturated fatty acids under solvent-free conditions, with high selectivity regarding the hydrogenation of C=C bonds. The influence of the support on the catalytic performance of the prepared Ni-based nanocomposites is particularly highlighted.

Regulation of Glucose Transport in Adipocytes by Interleukin-4.

Metabolic abnormalities such as obesity, insulin resistance, and type 2 diabetes mellitus are known to be associated with adipose tissue inflammation and impaired secretion of cytokines. Anti-inflammatory cytokine interleukin-4 (IL-4) was found to promote insulin sensitivity, glucose tolerance, and reduce lipid accumulation through multiple mechanisms, including direct regulation of lipolysis in adipocytes. However, little is known about its role in adipocyte glucose metabolism.

Grain-Based Dietary Background Impairs Restoration of Blood Flow and Skeletal Muscle During Hindlimb Ischemia in Comparison With Low-Fat and High-Fat Diets.

Among vascular pathologies associated with obesity, peripheral artery disease (PAD) occupies the important position. In clinical practice, nutritional interventions are recommended for patients with PAD. In this work, we investigated how the different dietary backgrounds affect the regeneration rate of ischemic hindlimb in mice.

NDRG1 Activity in Fat Depots Is Associated With Type 2 Diabetes and Impaired Incretin Profile in Patients With Morbid Obesity.

Objective: We aimed to investigate insulin-, mTOR- and SGK1-dependent signaling basal states in morbidly obese patients' fat. We analyzed the correlation between the signaling activity, carbohydrate metabolism, and incretin profiles of patients.

Methods: The omental and subcutaneous fat was obtained in patients with obesity.

hTERT-immortalized adipose-derived stem cell line ASC52Telo demonstrates limited potential for adipose biology research.

In the modern world obesity and insulin resistance contribute to a high impact on the structure of mortality. Basic research and pharmacological screenings for the search of new targets and insulin sensitizers require relevant cell models of adipocytes. Today the 3T3-L1 preadipocytes cell line is a widely used mouse-based model for investigation of adipocyte biology.

New Luminescent Tetranuclear Lanthanide-Based Silsesquioxane Cage-Like Architectures.

Invited for the cover of this issue are Alexey N. Bilyachenko, Joulia Larionova and co-workers at the Russian Academy of Sciences, the Peoples' Friendship University of Russia, and University of Montpellier. The image depicts lanthanide-based cage-like silsesquioxanes exhibiting magnetic and luminescence properties that could constitute a particularly interesting new family related to multifunctional nanomaterials.

The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme.

A series of berberine and tetrahydroberberine sulfonate derivatives were prepared and tested against the tyrosyl-DNA phosphodiesterase 1 (Tdp1) DNA-repair enzyme. The berberine derivatives inhibit the Tdp1 enzyme in the low micromolar range; this is the first reported berberine based Tdp1 inhibitor. A structure-activity relationship analysis revealed the importance of bromine substitution in the 12-position on the tetrahydroberberine scaffold.

Dehydroabietylamine-based thiazolidin-4-ones and 2-thioxoimidazolidin-4-ones as novel tyrosyl-DNA phosphodiesterase 1 inhibitors.

Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a DNA repair enzyme that plays a key role in repairing damage caused by various antitumor drugs. It is a promising target in medicinal chemistry for the creation of cancer adjuvant therapy. Inhibition of this enzyme together with the use of anticancer chemotherapy enhances the effect of the latter.

New Luminescent Tetranuclear Lanthanide-Based Silsesquioxane Cage-Like Architectures.

The synthesis, structure, magnetic, and luminescence properties investigations of four new cage-like lanthanide-based silsesquioxanes (Cat) [(PhSiO ) (LnO ) (O)(NO ) (EtOH) (MeCN) ] (where Cat =Et N , PPh P and Ln =Eu , Tb and (Ph P) [(PhSiO ) (TbO ) (O) (NO ) ]⋅10MeCN are reported. They present an unusual prism-like topology of cage architectures and lanthanide-characteristic emission, which makes them the first luminescent cage-like lanthanide silsesquioxanes. One of the Tb -based cages presents a magnetic spin-flip transition.

Synthesis, Structure, Magnetic and Photoluminescent Properties of Dysprosium(III) Schiff Base Single-Molecule Magnets: Investigation of the Relaxation of the Magnetization.

We report here the synthesis, structure, magnetic and photoluminescent properties of three new bifunctional Schiff-base complexes [Dy(L ) (py) ][B(Ph) ]⋅py (1), [Dy(L ) Cl(DME)] ⋅ 0.5DME (2) and [Dy(L ) Cl] ⋅ 2.5(C H ) (3) (HL =Phenol, 2,4-bis(1,1-dimethylethyl)-6-[[(2-methoxy-5-methylphenyl)imino]methyl]; HL =Phenol, 2,4-bis(1,1-dimethylethyl)-6-[[(2-methoxyphenyl)imino]methyl]).

Single-molecule magnet behavior in luminescent carbazolyl Dy(iii) octahedral complexes with a quasi linear N-Dy-N angle.

We report the synthesis, photoluminescence and magnetic properties of two octahedral dysprosium complexes [DyR2(py)4][BPh4]·2py (1) and [DyR2(THF)4][BPh4] (2) (R = carbazolyl, py = pyridine, THF = tetrahydrofuran) exhibiting a quasi linear N-Dy-N angle in the axial direction, suitable for providing a coordination environment allowing the zero-field slow relaxation of magnetization.

Fashioning Prussian Blue Nanoparticles by Adsorption of Luminophores: Synthesis, Properties, and Imaging.

We report the postsynthetic functionalization of Prussian blue (PB) nanoparticles by two different luminophores (2-aminoanthracene and rhodamine B). We show that the photoluminescence properties of the fluorophores are modified by a confinement effect upon adsorption and demonstrate that such multifunctional nanosized systems could be used for in vitro imaging.

Room temperature magnetoelectric coupling in a molecular ferroelectric ytterbium(III) complex.

Magnetoelectric (ME) materials combine magnetic and electric polarizabilities in the same phase, offering a basis for developing high-density data storage and spintronic or low-consumption devices owing to the possibility of triggering one property with the other. Such applications require strong interaction between the constitutive properties, a criterion that is rarely met in classical inorganic ME materials at room temperature. We provide evidence of a strong ME coupling in a paramagnetic ferroelectric lanthanide coordination complex with magnetostrictive phenomenon.

Identification of novel inhibitors for the tyrosyl-DNA-phosphodiesterase 1 (Tdp1) mutant SCAN1 using virtual screening.

Spinocerebellar ataxia syndrome with axonal neuropathy (SCAN1) is a debilitating neurological disease that is caused by the mutation the Tyrosyl-DNA phosphodiesterase 1 (TDP1) DNA repair enzyme. The crucial His493 in TDP1's binding site is replaced with an arginine amino acid residue rendering the enzyme dysfunctional. A virtual screen was performed against the homology model of SCAN1 and seventeen compounds were identified and tested in a novel SCAN1 specific biochemical assay.

Dehydroabietylamine Ureas and Thioureas as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Enhance the Antitumor Effect of Temozolomide on Glioblastoma Cells.

A new class of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors was found among resin acid derivatives. Several novel ureas and thioureas derived from dehydroabietylamine were synthesized and tested for TDP1 inhibition. The synthesized compounds showed IC values in the range of 0.

Gold@Prussian blue analogue core-shell nanoheterostructures: their optical and magnetic properties.

Au@Prussian-Blue Analogue (PBA) shell nanoheterostructures are multifunctional nano-objects combining optical properties (surface plasmon resonance) of the Au core and magnetic properties of the PBA shell. We report in this article a series of new Au core@PBA shell nano-objects with different PBA shells: Au@K/Co/[FeII(CN)6] (2) and Au@K/Ni/[CrIII(CN)6]:[FeII(CN)6] (3) single PBA shell, as well as Au@K/Ni/[FeII(CN)6]@K/Ni/[FeIII(CN)6] (4) double PBA shell and Au@K/Ni/[FeII(CN)6]@K/Ni/[FeIII(CN)6]@K/Ni/[CrIII(CN)6] (5) triple PBA shell systems. The position and intensity of the Au SPR band, as well as the magnetic behaviour of the nanoheterostructures, are strongly affected by the shell composition and its thickness.

Making Prussian blue analogues nanoparticles luminescent: effect of the luminophore confinement over the properties.

In this communication, we report the post-synthetic functionalization of K+/Ni2+/[Cr(CN)6]3- Prussian blue analogue (PBA) nanoparticles by the 2-aminoanthracene luminophore to yield a bifunctional magneto-luminescent nanosystem. The photoluminescence properties of the fluorophore are found modified by the confinement effect upon adsorption, while the magnetic behavior of PBA is preserved.

Single-molecule magnet behaviour in a Dy(iii) pentagonal bipyramidal complex with a quasi-linear Cl-Dy-Cl sequence.

We report the synthesis and magnetic investigation of a dysprosium pentagonal bipyramidal complex [Dy(THF)5Cl2][BPh4] (1) exhibiting a linear Cl-Dy-Cl sequence suitable for providing a coordination environment allowing a zero-field slow relaxation of the magnetization. Besides, the complex also shows dual luminescence originating from [BPh4]- and Dy3+.

Dysprosium Single-Molecule Magnets with Bulky Schiff Base Ligands: Modification of the Slow Relaxation of the Magnetization by Substituent Change.

The synthesis, and magnetic and photoluminescence investigations of two bifunctional dysprosium complexes based on tridentate Schiff base ligands is reported. Magnetic investigations reveal a genuine single-molecule magnet (SMM) behavior, with out-of-phase signals up to 60 K, and tunable emission arising from the Schiff base ligands.

Prussian Blue Analogues for the Separation of Hydrocarbons in Humid Conditions.

The relative affinity of a series of Prussian Blue analogues presenting various chemical compositions for the adsorption of different gases, such as water vapor and hydrocarbons, was studied. The ability of Co[Co(CN)]·5.2HO for the separation of hydrocarbons in a humid atmosphere was demonstrated.