[Inhibitory reactions of the motor cortex neurons in the triggering of conditioned reflex organization in cats].

The neuronal impulse reactions of the motor cortex neurons (field 4) which are involved in the reflex realization were studied on the awakening cats trained to perform conditioned movement after the influence of two stimuli (the preliminary and the conditional). Slow cortex potential in vertex was registered simultaneously. It was established that before the response to the triggering signal (interstimuli period) high amplitude negative shift in the slow cortex potential is present.

Time course of cell proliferation in rat liver in the early postnatal ontogeny and role of epidermal growth factor in organization of proliferative regimen.

Circadian rhythm of DNA synthesis, mitotic activity, and duration of mitosis in rat liver were studied on days 3, 7, and 12 of life. Age-associated differences in the rhythmic parameters of these characteristics were detected. Epidermal growth factor plays an important role in the formation of cell proliferation rhythm in the early postnatal ontogeny and in the formation of proliferative hepatocyte pool.

Diurnal dynamics of cell proliferation in rat liver during early postnatal ontogeny and effect of epidermal growth factor on hepatocyte proliferative activity.

Circadian rhythms of DNA synthesis, mitotic activity, and duration of mitosis in rat liver were studied on postnatal days 3, 7, and 12. Some age-related peculiarities of these rhythms were revealed. Epidermal growth factor was found to play an important role in the formation of cell proliferation rhythm during the early postnatal ontogeny and in the regulation of the pool of proliferating hepatocytes.

[Quantitative aspects of an analysis of the multicomponent system during its transition to a qualitatively new condition].

The paper shows that any system acquires a qualitatively new state if the elements of this system change in number (increase or decrease relative to the standard reference point, i.e. normalcy, the prior status of the system, etc.

[Clinical and morphological characteristics of long-lasting cholestatic syndrome in patients with hepatitis A in the presence of HBV infection].

Long-standing cholestatic syndrome (LSCS) was diagnosed in 41 patients with hepatitis A and hepatitis A plus chronic persistent hepatitis B (HA + CPHB). Some patients had a cholestatic form of the disease. Morphological and morphometric liver parameters were measured at the height of icterus in 74 patients.

[Clinico-morphological characteristics of intrahepatic cholestasis in hepatitis A and delta infection].

Clinical and morphological characteristics were studied for a course of acute viral hepatitis A and delta with long-term cholestatic syndrome in asymptomatic carriers of HBsAg. 149 patients with moderate disease were examined, 53 of them had long-standing cholestasis syndrome. 96 viral hepatitis patients free of cholestasis served control.

[Integration of tissue-specific inhibitors and thyroid hormones in the regulation of proliferation of gastric gland epithelial cells].

G1- and G2-chalone effects of pig's stomach mucosa extract were registered in mice stomach gland epithelium. The inhibitory activity of chalones on cell's proliferation reduced following increased level of thyroid hormones. Local (chalones) and organism (thyroid hormones) factors cooperate in control of gland epithelial cell proliferation.

[Thyroid hormones in the regulation of the proliferation of epithelial cells of the stomach gland].

The control effects of thyroid hormones were registered in mice stomach gland epithelium. The growth fraction, rhythm, activity of proliferation changed differently in fundal and pyloric epithelium following increased level of thyroid hormones.

[Proliferative reaction of the epithelium of gastric glands to vagotomy and sympathectomy].

By means of autoradiography and metaphase arrest technique 24-hour rhythms and intensity of proliferative processes in the epithelium of gastric glands were studied, as well as morphometric status of these structures after vagotomy and drug sympathectomy in the rat. In both cases the reaction of glandular epithelium appeared with the increase of mitotic activity and the decrease of cell synchronization before the entry into DNA--synthesis and mitosis. The number of epithelial cells in gastric glands became reduced, but after vagotomy, unlike sympathectomy, mainly because of the lack of chief cells.

[Morphological features of milky spots of the rat omentum in inflammation].

The omental milky sports of the rat have been examined with the light and electron microscope after intraperitoneal stimulation by particulate coal and zymosan. No positive correlation between cell level proliferation in milky spots and alteration of their size has been found. The increase in size of milky spots is due to the inflow of cells from the blood and bone marrow.

[Proliferative activity of endotheliocytes of growing corneal capillaries in the rabbit].

The intensity of capillaries growth in the rabbit's cornea was investigated after chemical burn and exposure to colchicine. Proliferative activity was determined in endothelial cells along the course of newly formed capillaries. Growth intensity proved to be 2 times higher when burn and colchicine effects were combined, than in case of burn alone.

[Cell proliferation in mouse tissues after thymectomy and the administration of T-activin].

The epithelium of mouse cornea and lymph nodes was examined for DNA-synthetic and mitotic activity at different times after thymectomy and administration of T-activin, an active factor of the thymus. Thymectomy entails retardation of the rate of corneal epithelium regeneration, diminution in both tissues under study of the amplitude of oscillations in cell proliferation throughout the day. Administration to the animals of the immunoactive thymic factor T-activin makes the circadian rhythm of cell proliferation return to normal.

[Action of hepatic chalones on the proliferation of hepatocytes from intact and denervated livers].

The paper is concerned with the action of chalones, tissue-specific inhibitors of cell proliferation, on DNA synthesis and mitotic activity of hepatocytes in the intact and denervated liver during regeneration. Experiments were made on Wistar rats. Liver denervation was performed by bilateral subdiaphragmal vagotomy.

[Interaction of the circadian rhythms of the functional activity of the hypophyseal-adrenal system and of the mitotic activity in the esophageal epithelium of rats with experimental hypo- and hypercorticism].

In experimental hypercorticism the average daily concentration of glucocorticoids in blood plasma is 4 times higher than in control one, the amplitude of the circadian rhythm increases almost 3 times, the time of maximum concentration does not change. The adrenocorticotrophic hormone (ACTH) average circadian concentration decreases twofold. The adrenalectomy results in abrupt smoothing down of the circadian rhythm of glucocorticoids concentration and in increasing (in 2,4 times) of the average circadian concentration of ACTH.

[Inducing action of hydrocortisone on mitotic rhythm in the epithelium of rat cornea and esophagus].

Circadian rhythms of mitoses were studied in the epithelium of the cornea and esophagus of rats given hydrocortisone. The hormone was injected daily during 7 days at 4-5 p.m.

[Interaction of chalones and glucocorticoid hormones in regulation of cell division].

The action of hepatic chalone on cell proliferation in inoculated hepatoma 22a of mice was studied in the presence of a changed level of glucocorticoid hormones in experimental animals. Chalone was obtained from the liver of intact rats by ethanol precipitation. The intensity of cell proliferation in hepatoma was evaluated by the colcemide and autoradiography methods.

[Diurnal rhythm of mitoses and rate of cell renewal in rat tissues following adrenalectomy].

Numbers of mitoses and of colchicine mitoses, and the duration of mitosis in corneal and tongue epithelium as well as in hepatocytes of intact and adrenalectomized rats have been studied in dynamics within 24 hours. In the control animals, the 24 hours rhythm of mitotic activity and the duration of mitosis were established. The length of mitosis falls during the high rate mitotic activity to increase when the number of dividing cells is reduced.

[Circardian rhythm of mitoses in the epithelium of the cornea after splenectomy].

In corneal epithelium of CBA mice the index of colchicine mitoses diminished after splenectomy in the day period characterized by rising mitotic activity in control animals. The duration of active phase of cell division rhythm shortened while the maximum of mitotic activity delayed in comparison with control animals. The total amount of cells entering mitosis during 24 hours diminished by 27.