Publications by authors named "Mamisa Chabula-Nxiweni"
Article Synopsis
- Factors driving the rise of drug-resistant tuberculosis (TB) in the Eastern Cape, South Africa, remain unclear despite a study of 651 TB isolates conducted from July 2008 to July 2009.
- Molecular analysis revealed that drug-sensitive and multidrug-resistant TB strains had diverse genetic backgrounds, while pre-XDR and XDR TB had more limited genetic diversity.
- A significant correlation was found between second-line drug resistance and the atypical Beijing genotype, with high rates of clustering indicating possible transmission, and many isolates exhibiting resistance to multiple anti-TB drugs, raising concerns about totally drug-resistant TB.
The aminoglycosides amikacin (AMK)/kanamycin (KAN) and the cyclic polypeptide capreomycin (CAP) are important injectable drugs in the treatment of multidrug-resistant tuberculosis. Cross-resistance among these drug classes occurs and information on the minimum inhibitory concentrations (MICs), above the normal wild-type distribution, may be useful in identifying isolates that are still accessible to drug treatment. Isolates from the Eastern Cape Province of South Africa were subjected to DNA sequencing of the rrs (1400-1500 region) and tlyA genes.
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