[The upper limit of individual normal range of intraocular pressure--a personalized criterion for IOP evaluation].

Objective: To determine clinical value of the use of the upper limit of individual normal range of intraocular pressure (IOP) in glaucoma diagnosing.

Material And Methods: The study enrolled 229 conditionally healthy participants (229 eyes) with no ocular complaints after a basic ophthalmic assessment. Ocular blood flow and IOP were measured with Ocular Blood Flow Analyzer (Paradigm Medical Industries).

[Intraocular pressure and ocular blood flow features intravitreal infection of anti-vascular endothelial growth factor agents].

Objective: to investigate intraocular pressure (IOP) and ocular blood flow (OBF) changes as well as the individual normal range of IOP in patients with age-related macular degeneration (AMD) with or without concomitant glaucoma after intravitreal anti-vascular endothelial growth factor (VEGF) therapy.

Material And Methods: Group 1 included 34 patients (34 eyes) with AMD and no glaucoma, group 2-34 patients (34 eyes) with both AMD and glaucoma. In all patients the IOP and OBF were measured (with Ocular Blood Flow Analyzer) and the individual normal range of lOP calculated before the treatment, on the third day after the injection and at the 1-month follow-up visit.

[Determination of the individual normal range of intraocular pressure in differential diagnosis between pseudonormal tension glaucoma and ischemic optic neuropathies].

The study investigated the relation between the actual intraocular pressure (IOP) and its individual normal range in normal-tension glaucoma (NTG) and ischemic optic neuropathy (ION) outcome. A total of 39 patients (61 eyes) were examined. Group 1 included 19 patients (35 eyes) with newly diagnosed NTG, group 2--20 patients (26 eyes) with the ION outcome.

[Hybrid phacoemulsification: a new stage in the improvement of cataract surgery (?)].

Purpose: To evaluate the early results of femtosecond laser application in phacoemulsification of cataracts of different density.

Material And Methods: Femtosecond laser-assisted phacoemulsification cataract surgery was performed on 277 patients (390 surgeries) with II-IV degree lens nuclear density.

Results: The use of femtosecond laser for capsulorexis and lens nucleus fragmentation enables forming of a well-shaped, properly sized, and accurately centered aperture in the anterior lens capsule, reduces the equivalent time of ultrasound exposure (by 30% in average) and decreases the total time of nuclear fragments emulsification by a third.

[Experimental and morphological study of the effect of antiangiogenic therapy on corneal neovessels].

The article presents the results of an experimental and morphological study of combined antiangiogenic effect of photodynamic therapy with Photosens photosensitizer and Avastin (bevacizumab) on neovascularization process in corneal stroma. The combined approach has demonstrated an advantage over separate application of these methods, what, however, has to be proved clinically.

[Hemodynamic changes in myopia of different degrees].

A total of 78 patients (143 eyes) with low, medium and high degree myopia were assessed. Apart from standard ophthalmological tests, flowmetry and duplex ultrasound of ocular vessels were performed in all cases to evaluate volumetric and velocity parameters of ocular blood flow in relation to the length of anterior-posterior axis and the degree of myopia. It is found that both parameters of regional blood flow progressively decrease as the anterior-posterior axis increases.

[Selective principle of modern approaches in keratoplasty].

Currently accepted selective principle of modern therapeutic-optical keratoplasty is based on well-known advantages of target substitution of the damaged corneal layers. This article covers the variety of selective keratoplasty methods for different anatomical levels of corneal involvement. Major advantages of up-to-date keratoplasty methods involving high end surgical technologies have been analyzed.

[Differentiation of concomitant glaucomatous optic neuropathy in optic disc drusen].

Characteristics of ocular blood flow (OBF) in primary open-angle glaucoma (POAG) in eyes with optic disc drusen have been investigated. The study enrolled 21 patient (35 eyes) with optic disc drusen, of which 7 (8 eyes) were diagnosed with POAG. Besides the standard tests, the ophthalmological assessment included evaluation of OBF (flowmetry) and an individual normal range of intraocular pressure (IOP).

[Peculiarities of ocular blood flow in ischemic optic neuropathy and normal tension glaucoma].

Characteristics of ocular hemodynamics in ischemic optic neuropathy (ION) outcome and normal tension glaucoma (NTG), the conditions that are difficult to be differentially diagnosed, have been investigated. The study enrolled 32 patients (40 eyes) with ION outcome, 26 patients (46 eyes) with NTG, and 20 patients (32 eyes) with no ocular pathology. Besides the standard ophthalmological examination, color Doppler imaging of ocular vessels, evaluation of ocular blood flow volume and individual normal range of intraocular pressure (flowmetry) were performed in all cases.

[Top-hat keratoplasty in surgical treatment of bullous keratopathy].

Outcomes of different modifications of top-hat keratoplasty were assessed in 48 patients (48 eyes) with bullous keratopathy. In the 1st group manual top-hat keratoplasty was performed in 7 patients. 30 patients of the 2nd group underwent manual half-top-hat keratoplasty.

[The results of up-to-date techniques of automated endothelial keratoplasty].

The results of different techniques of automated endothelial keratoplasty (EKP) performed in 72 patients with bullous keratopathy are estimated. Automated EKP with superficial flap was performed in 18 patients (1st group), Descemet stripping automated EKP (DSAEK) - in 26 patients (2nd group), Descemet stripping automated EKP (DSAEK) with thin grafts - in 20 patients (3rd group), Descemet membrane automated EKP with stromal rim (DMAEK) - in 8 patients (4th group). According to our results DSAEK with thin grafts is indicated to elderly patients with severe ocular disease (ocular comorbidities, repeated surgery, advanced keratopathy).

[Functional results of contact lens correction and penetrating keratoplasty in keratoconus. Report 2. Wavefront analysis].

Comparative analysis of optic aberrations in contact lens correction and after penetrating keratoplasty (PKP) in keratoconus are presented. 117 patients (219 eyes) with stage I-IV keratoconus, wearing rigid gas-permeable contact lenses (RPCL), and 60 patients (64 eyes) after PKP were examined using OPD Scan (NIDEK, Japan) to assess aberration characteristics. Total optic aberrations and higher-order aberrations of ocular and corneal wavefront were significantly increased after PKP compared to those in patients with I-III stage keratoconus wearing RGCL.

[Functional results of contact lens correction and penetrating keratoplasty in keratoconus. Report 1. Analysis of resolution ability of the eye].

Comparative analysis of functional results of contact lens correction and penetrating keratoplasty (PKP) in keratoconus are presented. To assess resolution ability we considered visual acuity and contrast sensitivity. 117 patients (219 eyes) with stage I-IV keratoconus, wearing rigid gas-permeable contact lenses (RPCL), and 60 patients (64 eyes) after PKP were examined.

[Comparative analysis of several morphometric parameters received using optic coherent tomography and scanning laser ophthalmoscopy in initial glaucoma diagnosis].

Retinal morphometric parameters received using confocal scanning laser ophthalmoscopy and optic coherent tomography (OCT) are compared. OCT was performed using Stratus OCT 3000 ("Carl Zeiss Meditec"), and for confocal scanning laser ophthalmoscopy we used Heidelberg retinal tomography HRT 3.0 ("Heidelberg Engineering").

[The role of tear acidity and Cu-cofactor of lysyl oxidase activity in the pathogenesis of keratoconus].

Detailed analysis of copper compounds migration in the corneal stroma are presented. The biochemical conditions of the middle periphery of the cornea is found to inhibit copper ions movement to the center in patients with keratoconus due to increased tear alkalinity. Low concentration of dichlorocuprate (I) ion in the center of cornea results in inactivation of lysyl oxidase, an enzyme that catalyzes collagen cross-linking, and thus promotes keratoconus.

[Diagnostic value of macular morphometry in patients with primary open-angle glaucoma].

In this article the results of practical use of central retinal zone (CRZ) tomography in primary open-angle glaucoma (POAG) measured with RTA (Retinal thickness Analyzer, Talia Technology Ltd., Israel) are presented. 460 patients (790 eyes) aged 45-85 years old were included into the study.

[Results of clinical evaluation of a new screening method for determining the individual normal level of intraocular pressure].

The paper presents the results of practical application of a new screening method for determining tolerant intraocular pressure (TIOP) on a Blood Flow Analyzer (Paradigm, USA). Studies were conducted on 331 eyes (205 subjects). Group 1 consisted of 80 patients (126 eyes) without glaucoma being found, with intraocular pressure (IOP) in the average normal range, but with a TIOP excess of 1-8 mm Hg (a risk group); Group 2 included 15 subjects (20 eyes) without glaucoma with normal IOP in whom TIOP exceeded the existing IOP by 1-7 mm Hg; Group 3 comprised 110 patients (185 eyes) with Stage I-III primary open-angle glaucoma (POAG) with compensated IOP.

[New modification of complete corneal stromoplasty].

New technical elements of complete corneal stromoplasty were practiced in an experiment on 25 isolated cadaver eyes; then 7 operations were clinically performed on 7 eyes according to the same procedure. The results have shown that the experimentally tested new technique may be successfully applied in the clinical setting.

[Results of combination surgical treatment for open-angle glaucoma and cataract].

The results of 257 combined, pathogenically oriented operations were analyzed in 181 patients with cataract concurrent with open-angle glaucoma (OAG). A system of pathogenically oriented combined surgical interventions was shown to be highly effective in patients with cataract concurrent with OAG. The proposed procedure for intraoperative determination of the retention of intraocular fluid allows a pathogenically oriented antiglaucomatous component of combined surgery to be chosen in patients with cataract and OAG.

[A new screening method for determining tolerant intraocular pressure].

The authors proposed a new screening for determining individual tolerant intraocular pressure (TIOP). The investigation covered 107 individuals (167 eyes). All the examinees were divided into three groups.

[Morphological features of regenerative-reparative processes in the cornea exposed to synthetic analogues of endogenous peptide fragments of protein S100b in an experiment].

The effects of two 5-membered (SP5, SP6) endogenous synthetic peptide fragments of protein S100b on the course of regenerative-reparative processes in the corneas of Wistar rats were morphologically studied after making a graduated injury. Conjunctival or endonasal injection of the peptides was made at two concentrations of 10(-6) and 10(-8) M. The study peptides were found to have a modulating effect on regenerative-reparative processes regardless of the route of administration and to induce accelerated and qualitative corneal wound healing as compared with the controls.

[Calculation of the focal power of an intraocular lens in the anterior segment sizes disproportional to the length of the anteroposterior axis of the eye].

Ultrasound and optical coherent biometries were used to study the influence of the biometric parameters of the anterior segment of the eyeball on the precision of calculation of the focal power of an intraocular lens (IOL). A clinical study has demonstrated that among the biometric parameters of the anterior segment of the eyeball, there is a close correlation of miscalculation of IOL focal power with the diameter of the cornea "from white to white" and accordingly with the diameter of the floor of the corneal segment. Based on the findings, the authors have developed a procedure for calculating the focal power of an IOL for cases of the disproportion of the corneal segment to the IOL length of the eyeball.

[A surgical treatment for neovascular terminal glaucoma (preliminary communication)].

In 40 patients with terminal neovascular glaucoma of various genesis (visual acuity 0 to wrong light projection), 4 rectus muscles were tightly ligated at the insertion site of their strings to the sclera of the eyeball with silk threads under local anesthesia. The threads were not postoperatively removed and left under the conjunctiva (Invention Patent No. 2286752 of November 10, 2006).