The IL6 gene polymorphism -634C>G and IL17F gene polymorphism 7488T>C influence bone mineral density in young and elderly Japanese women.

Osteoporosis is an important public health problem because of the significant morbidity and mortality associated with its complications, particularly fractures. An important clinical risk factor in the pathogenesis of osteoporosis is the presence of genetic polymorphisms in susceptibility genes. However, few studies have investigated the relevance of these polymorphisms in premenopausal women.

Walking velocity measured over 5 m as a basis of exercise prescription for the elderly: preliminary data from the Nakanojo Study.

Moderate-intensity physical activity is recommended to promote health, and augment peak oxygen transport, thus reducing the risk of chronic disease, and delaying functional loss in the elderly. The optimal method of prescribing the recommended intensity of effort [approximately 50% of oxygen intake reserve ( V(.)O(2reserve)) or heart rate reserve (HR(reserve))] remains unclear for this age group.