Publications by authors named "Mamiko Mori"
Background/aim: Rho small GTPases regulate cancer cell adhesion, migration and invasion through reorganization of the actin cytoskeleton. Rho GTPase Activating Protein 22 (ARHGAP22) is a Rac-specific GAP and suppresses Rac-dependent lamella formation and cell spreading. We have previously shown that ARHGAP22 localizes at endosomes in human melanoma A7 cells.
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- * FilGAP, a GTPase-activating protein for Rac, is critical for maintaining this polarity; its overexpression enhances migration speed while its depletion negatively affects cell movement and shape.
- * The interaction of FilGAP with PIP3 and the small GTPase Arf6 is key to regulating cell polarity and migration, highlighting the complex mechanisms that control tumor cell movement.
Rho small GTPases control cell morphology and motility through the rearrangement of actin cytoskeleton. We have previously shown that FilGAP, a Rac-specific GAP, binds to the actin-cross-linking protein Filamin A (FLNa) and suppresses Rac-dependent lamellae formation and cell spreading. ARHGAP22 is a member of FilGAP family, and implicated in the regulation of tumor cell motility.
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