Publications by authors named "Mamiko Demura"
Article Synopsis
- Vonoprazan is a potassium competitive acid blocker that's shown to be more effective than proton pump inhibitors (PPIs) in treating erosive gastroesophageal reflux disease (GERD), with this study focusing on its use in maintenance therapy.
- The study involved 122 patients in a randomized cross-over design comparing vonoprazan and lansoprazole, measuring GERD symptoms through various scales over two 4-week periods.
- Results indicated better symptom control with vonoprazan, with over 93% of patients achieving symptom relief, suggesting it as a viable alternative to PPIs for continuous GERD treatment.
Introduction: The first drug selected for treatment of gastro-oesophageal reflux disease (GERD) and prevention of the recurrence is a proton pump inhibitor (PPI), but recently, a potassium-competitive acid blocker (P-CAB) was put on the market in Japan. Its onset of effect is faster than PPI, and it takes more than 2 days to recover acid secretion after the withdrawal period. Therefore, unlike PPI, the usefulness of every other day administration or discontinuous administration is expected.
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