[HEPATITIS C INFECTION SPECIFIC MARKERS AMONG PATIENTS WITH BREAST CANCER IN AZERBAIJAN].

The article presents results of comparative investigation of blood serum in 2682 breast cancer (BC) patients and 3323 healthy persons. At the onset of the study, all the specimens were tested for serum antibodies to hepatitis C virus (HCV). At the later stage, the serum specimens containing the antibodies were examined for detecting RNA GCV.

[The comparative characteristic of two methods of detection of mutations of beta-globin gene].

Nowadays, two methods of detection of mutations of beta-globin gene are applied: amplification of refractory mutation system and reverse dot-blot-hybridization. The study was implemented to comparatively analyze effectiveness of these methods of molecular diagnostic in detection of thalassemic mutations in Azerbaijan. The examined sample consisted of 82 patients with both homozygous and heterozygous thalassemia and drepanothalassemia as well.

[The serum erythropoietin under intermediate B-thalassemia].

The study explored the level of serum erythropoietin in patients with intermediate beta-thalassemia to determine possible correlations with hemoglobin level and fetal hemoglobin level and other parameters. The sampling consisted of 58 examined patients with intermediate beta-thalassemia. The contrl group consisted of 30 healthy persons.

[Diagnosis of beta-thalassemia].

The purpose of the case study was to evaluate the potentialities of using the data found by hematology analyzers in the diagnosis of beta-thalassemia. Eighty (80) persons with homozygous beta-thalassemia, 180 carriers of the beta-thalassemia gene and 50 healthy subjects were examined. Counts of erythrocytes, content of hemoglobin, hematocrit and erythrocytes indices (MCV, MCH, MCHC) were determined in all of them.

[Cellular mechanisms of calcium regulation of cardiac rhythm in children with ectopic arrhythmias].

Regulation of intracellular calcium homeostasis by means of secondary mediators calmodulin and 4,5-inositol phosphates (products of phosphatidyl inositol hydrolysis) was studied in children with ectopic forms of arrhythmias. Alterations in the system calmodulin-Ca2+ and the activity of phosphoinosite metabolism correlated highly with clinical manifestations of the arrhythmias. The data obtained suggest that a number of molecular mechanisms and responsible for arrhythmias were realized in cell membranes and depended on a complex of intracellular messengers affected within various steps of the hormonal signal transmission.

[Spectrum of DNA haplotypes and beta-thalassemia mutations linked with them in the Azerbaijan Republic].

Haplotyping of the beta-globin gene cluster was performed on DNA samples from 110 Azerbaidzhanian beta-thalassemic patients and their families. During this study, we found 18 different haplotypes and determined the frequency of their occurrence. Nine of these haplotypes have never been observed earlier in the studied population.

[Heterozygote carrier state of hemoglobin S in Azerbaijan].

Clinico-hematological characteristics of 123 HbS heterozygotes have been presented. A total of 16 subjects with the level of HbS less than 30% were detected. Intraerythrocytic inclusions observed in single cells, as well as a significant decrease in the mean hemoglobin level, ESR and mean cell hemoglobin denote the presence of concomitant alpha-thalassemia-I in this group of heterozygotes.