[INCIDENCE OF CORONARY HEART DISEASE IN COMBINATION WITH TYPE 2 DIABETES MELLITUS ESTIMATED FROM RESULTS OF AN EPIDEMIOLOGICAL STUDY OF 20-59 YEAR OLD WOMEN].

We report evaluation of the incidence of coronary heart disease (CHD) in combination with type 2 diabetes mellitus (DM2) estimated from results of an epidemiological study of 20-59 year old women. CPD was shown to occur twice more frequently in association with DM2 especilly in the age groups of 30-39 and 50-59 years.

Tyrosinase inhibition studies of cycloartane and cucurbitane glycosides and their structure-activity relationships.

In the present paper, tyrosinase inhibition studies and structure-activity relationship of eight cycloartane glycosides and one cucurbitane glycoside and its genin, which were isolated from Astragalus (Leguminoseae) and Bryonia (Cucurbitaceae) plants, have been discussed. The activities are compared with two reference tyrosinase inhibitors, kojic acid and l-mimosine. These studies and the SAR showed that the askendoside B which exhibited highly potent (IC50 =13.

[Biological and psychosocial factors as a reason for enuresis in children].

Biological (pregnancy in neurotic mothers) and psychosocial (wrong attitude of the family to enuretic child) risk factors were studied in 68 children with enuresis aged 4 to 15 years. It is shown that the presence of biological and psychosocial factors in combination with enuresis in children necessitate antenatal consultations of obstetricians, pediatrists, psychologists and parents on prevention of enuresis in children, active screening-testing children with enuresis for dysfunction of the urinary bladder and psychoneurological disorders affecting harmonic development of personality in children.

[Burden of hereditary diseases in residents of the Mari El Republic].

A summary of the medical genetic studies of the Marii El population is presented. A total of 276,900 people, 110,894 and 166,006 urban and rural inhabitants, respectively, were examined. Regarding the ethnic composition, the studied population was mostly Mari (61.

[A medico-genetic description of inhabitants of two regions of the Kransnodar Krai].

The spectrum and prevalence rate of hereditary pathology in Kanevskii and Bryukhovetskii raions (districts) of Krasnodar krai (territory) were analyzed. The total size of the studied population was 145,937. The prevalence rate of monogenic hereditary pathology was estimated.

[Diversity of hereditary pathology in the population of Marii El Republic and its differentiation with respect to gene frequencies for hereditary diseases].

The diversity of Mendelian hereditary pathology was studied in Marii El Republic. In total, 276,900 subjects, including 171,151 Maris and 88,714 Russians, living in seven raions (districts) were studied. Fifty-five autosomal dominant disease entities were found, with more than ten diseases having a frequency of 1:50,000 people or higher.

[Medico-genetic study of residents of Marii El republic: burden of hereditary diseases in four regions of the republic].

A medical genetic study of Orshanskii, Morkinskii, Sovetskii, and Semurskii raions (districts) of the Marii El Republic was performed. The total number of subjects examined was 115,743. Meadow Maris and Russians accounted for the most part of the populations of the districts studied.

[The spectrum of spinal muscular atrophies: a population study].

A population medical genetic study of spinal muscular atrophies (SMA) was carried out in 1800 individuals in 6 russian and 3 middle asian regions. 33 patients with SMA were ascertained including 29 with autosomal recessive childhood proximal SMA (SMA I-III) and 4 patients with rare SMA types. There were revealed either overlapping of diagnostic criteria of I-III types in some patients or interfamilial differences of types in 3 from 6 familial cases, (one of them with distant relatives affected as well as pronounced clinical genetic variability of rare forms of SMA (all sporadic cases).

[Genetico-demographic characteristics of the population from three districts of the Bryansk region].

Results of genetic demographic investigation of three nations located in west Bryanskaya oblast (Klintsovskii, Klimovskii, and Starodubskii nations) are presented. A comparison is made with respect to a number of demographic parameters of "southern" (Krasnodar) and "northern" (Kirov) Russian populations. A low level of the Crow index, which is associated with a differential mortality rate, Im = 0.

[Genetic structure and the load of hereditary diseases in five populations of Arkhangel'skaia region].

A population and medical genetic investigation was performed in a number of raions in the Arkhangel' skaya oblast. Random inbreeding coefficients were 0.000358 and 0.

[Monogenic hereditary diseases in Gorno-Mariĭskiĭ district of Mariĭ El republic].

The population of Gornomariiskii raion, Marii El Republic, primarily made up of mountain Marii, was subjected to medical genetic examination. The size of the entire population is 54853. Estimates of hereditary pathology in urban and rural populations of the raion were obtained.

[Population genetics of spinal muscular atrophy].

A population genetic study of spinal amyotrophy (SMA) in six Russian and three Central Asian regions was carried out. In total, 29 patients with autosomal recessive (AR) infantile proximal SMA (SMA I-III) and four patients with rare SMA forms with an unspecified type of inheritance were revealed. In Russian populations, the prevalence of SMA I-III is similar (1.

[Hereditary spastic paraplegias: a comparative study of Russian populations].

15 families (27 patients) with hereditary spastic paraplegia (HSP) were found in the course of monogenic disorders investigation in 6 Russian populations. High HSP prevalence (7.21+1.

[Population sturcture of the Gorno-Mariĭskiĭ region of the Mariĭ El Republic].

The genetic structure of the population of the Gorno-Mariiskii raion, Marii El Republic, was studied. The population consists of two major groups, highland Mari and Russians. The former constitute the majority of the rural population, and the latter, the majority of the urban one.

[Comparison of several Russian populations by vital statistics and frequency of genes, causing hereditary diseases].

Distances computed from vital statistics using the Euclid formula and thus termed "vital" are proposed for use in population studies. An example of use of these statistics for comparison of four large geographically separated Russian populations is given.

[Use of an index of migration, indicators for surname diversity, entropy and redundancy for surname distribution in describing the population structure].

The index of migration, the parameter of surname diversity, and the values of entropy and redundancy of the distribution of surnames, proposed by Barrai et al. [1], were determined for populations of Kirovskaya and Kostromskaya oblasts. The relationship of these indices with previously used population characteristics, such as the Wright's F st parameter, the index of endogamy, and the burden of autosomal recessive and autosomal dominant Mendelian pathology, was determined.

[Genetic structure of populations and characteristics of geographic distribution of autosomal recessive diseases in the Kirov region].

The genetic structure of human populations inhabiting Kirov region is described. The effect of genetic drift on geographical distribution of families with autosomal recessive diseases is analyzed. Genetic distances were calculated from frequencies of occurrence of certain family names and frequencies of autosomal recessive genes encoding hereditary diseases.

[Comparison of the population of the Krasnodar region with other Russian populations regarding genetic and demographic parameters].

The estimates of some genetical and demographical parameters important for populational structure of the population of West part of Krasnodar province are presented. The differences in forming of population structure of districts was revealed. In general, the decrescent type of reproduction, active family planning (average family value is 2.

[Population genetic study of hereditary motor and sensory neuropathy in the Kirov region].

All the cases of hereditary motor and sensory neuropathy (HMSN) in an eastern part of Kirov region (Russian north-east) were ascertained (N = 42 including 11 persons with pre/subclinical forms; m: f = 1). HMSN prevalence is 15.95 +/- 2.

[Structure and variability of hereditary disease in the Kirov Province].

The main purpose of this report is to present the nosological spectrum of hereditary diseases in 9 Districts of Kirov Province and to compare it with that studies earlier in other Russian populations. This comparison is undertaken in an attempt to define a "nucleus" of hereditary diseases in the Russian population studied. During this study 343 families with 546 affected were registered.

[Prevalence of hereditary pathologies in residents of the Kirov Province].

Medical-genetic study was carried out in the population of Kirov Province (population size about 120.000). 203 families with 334 affected with hereditary disorders were registered.

[Effect of long-term treatment with prazosin and its combination with nadolol on the levels of blood hormones of the hypophyseal- gonadal system in patients with hypertension].

The levels of pituitary and gonadal hormones were measured by radioimmunoassay during a long-term (12-month) therapy with prazosin and its combination in 23 patients aged 30-59 years who suffered from Stage II hypertensive disease. Prazosin monotherapy resulted in a significant decrease in prolactin levels, followed by inhibited elaboration of luteinizing, follicle-stimulating, and testicular hormones in the first 6 months of therapy without changing estradiol levels. The hypoprolactinemic effect of prazosin was significantly enhanced with an increase in therapy duration and more profound in patients who had high baseline prolactin levels and in younger patients.

[Uncovering the features of population genetic structures by the descriptive method of "genetic landscape"].

It was found that using surnames as genetical markers in rural Russian populations gives adequate results under conditions of working on the area not extending over the territory of 2 or 3 adjacent regions. Schematic drawings of genetic landscapes in 4 regions of the Kirov district and in 2 regions of the Adyg district are presented. Analysis of anomalous features of equidistant lines has been performed.

[State of the hypophyseal-gonadal system in patients with hypertension during long-term treatment with nadolol and anaprilin].

The changes in hormone levels of the hypophyseal-gonadal system were studied during 6-month monotherapy with nadolol, 40-160 mg/day, or anaprilin, 80-240 mg/day, in 40 males with Stage II hypertensive disease. Serum levels of prolactin, luteinizing, follicle-stimulating, and testicular hormones, and estradiol were measured by radioimmunoassay at the end of control placebo, 2-week, 2- and 6-month therapy. The negative changes revealed in the hypophyseal-gonadal system, as manifested by elevated prolactin and estradiol levels, diminished testicular hormone concentration, indicate that the levels of these hormones should be monitored in a long-term antihypertensive therapy with beta-adrenoblockers.

[Frequency criterion of choice of surname for the study of the genetic structure of the population].

On the example of 7 populations of the regional level allowability of using surnames with frequencies exceeding 0.001 in adequate estimation of the population structure indices is shown. The correlation coefficient between genetical distances calculated with the help of all surnames in the list, and those estimated using only frequent surnames was more than 0.