ACTL6A: unraveling its prognostic impact and paving the way for targeted therapeutics in carcinogenesis.

Increased Actin-like 6A (ACTL6A) expression is associated with various cancers, but its comprehensive investigation across different malignancies is lacking. We aimed to analyze ACTL6A as a potential oncogene and therapeutic target using bioinformatics tools. We comprehensively analyzed ACTL6A expression profiles across human malignancies, focusing on correlations with tumor grade, stage, metastasis, and patient survival.

Oncogenic Potential of Replication Factor C Subunit 4: Correlations with Tumor Progression and Assessment of Potential Inhibitors.

Replication Factor C Subunit 4 (RFC4), an oncogene implicated in many human cancers, has yet to be extensively studied in many cancer types to determine its expression patterns and tumor tissue function. Various bioinformatics tools were used to analyze RFC4 as a potential oncogene and therapeutic target across many cancers. We first examined RFC4 expression levels in several human tumor types to determine relationships with tumor grade, stage, metastasis, and patient survival.

Targeting Cancer Stem Cells as the Key Driver of Carcinogenesis and Therapeutic Resistance.

The emerging concept of cancer stem cells (CSCs) as the key driver behind carcinogenesis, progression, and diversity has displaced the prior model of a tumor composed of cells with similar subsequently acquired mutations and an equivalent capacity for renewal, invasion, and metastasis. This significant change has shifted the research focus toward targeting CSCs to eradicate cancer. CSCs may be characterized using cell surface markers.

Reliability of near-infrared spectroscopy measures of cerebral oxygenation and blood volume during handgrip exercise in nondisabled and traumatic brain-injured subjects.

We compared the test-retest reliability of near-infrared spectroscopy (NIRS) measures of cerebral oxygenation and blood volume during a rhythmic handgrip exercise in 13 nondisabled subjects and 25 subjects with moderate to severe traumatic brain injury (TBI). Subjects with TBI (average Glasgow Coma Scale score = 4.2, average time since injury = 21 mo) had completed an acute brain injury rehabilitation program.

Effects of circuit training on body composition and peak cardiorespiratory responses in patients with moderate to severe traumatic brain injury.

Objective: To examine the time course of the changes in body composition and peak cardiorespiratory fitness resulting from routine brain injury rehabilitation program (BIRP) activities and circuit training in patients with moderate to severe traumatic brain injury (TBI).

Design: Time-series design spanning 18 weeks. Trials T1 and T2 were completed in weeks 1 and 2, respectively, to establish reliability of the measurements, followed by trial 3 (T3) 4 weeks later to evaluate changes resulting from the BIRP.

Reliability of erector spinae oxygenation and blood volume responses using near-infrared spectroscopy in healthy males.

The purpose of this investigation was to (1). describe the trends in oxygenation (OXY) and blood volume (BV) of the right and left paraspinal muscles during the Biering-Sorensen muscle endurance (BSME) test using near infrared spectroscopy (NIRS), and (2). assess the test-retest reliability of OXY and BV changes during the BSME in healthy males.

Reliability of peak cardiorespiratory responses in patients with moderate to severe traumatic brain injury.

Objective: To examine the test-retest reliability of acute physiologic responses in patients with traumatic brain injury (TBI).

Design: Repeated measures within 1 week.

Setting: Brain injury rehabilitation program and community rehabilitation hospital.