Overexpression of heat shock protein 27 (HSP-27) is associated with bad prognosis in oral squamous cell carcinoma.

Background: Heat shock protein 27 (HSP‑27) is a member of the small-molecular-weight HSP family, the expression of which is increased when cells are exposed to elevated temperatures or any other kinds of stress; it seems that the cellular protective properties this protein demonstrates might also help cancer cells stay immortal. Family members of HSPs are either expressed continuously or controlled inductively, and are present in different subcellular structures.

Objectives: The aim of this study was to investigate the prognostic value of HSP‑27 expression in the histological grades of oral squamous cell carcinoma (OSCC).

Amelogenin is a Potential Biomarker for the Aggressiveness in Odontogenic Tumors.

Amelogenin (AMEL), the major structural protein of the enamel organic matrix, constitutes more than 90% of the enamel’s protein content, Aberrations of amelogenin are thought to be involved in the oncogenesis of odontogenic epithelium. The expression of amelogenin is possibly an indicator of differentiation of epithelial cells in the odontogenic tumors. Aim of the study: Investigating the expression of amelogenin in some odontogenic tumors, using an anti-amelogenin polyclonal antibody, and then compare it with AMEL expression in tooth buds as control.