Publications by authors named "Mamdouh Aker"
Laryngeal cancer treatment decision making: A conjoint analysis of general public attitudes and priorities.
Laryngoscope Investig Otolaryngol
August 2023
Objective: Patients with advanced laryngeal cancer are typically presented with divergent treatment options, namely chemoradiation versus total laryngectomy. This study aims to understand general perspectives of the factors involved in this decision-making process.
Methods: Surveys were constructed using specialized conjoint analysis software.
Background: Partial gland ablation (PGA) is a new option for treatment of prostate cancer (PCa). Cryotherapy, an early method of PGA, has had favorable evaluations, but few studies have employed a strict protocol using biopsy endpoints in men with clinically significant prostate cancer (csPCa).
Methods: 143 men with unilateral csPCa were enrolled in a prospective, observational trial of outpatient PGA-cryotherapy.
Pigs have become important animal models in voice research. Several objective parameters exist to characterize the pig voice, but it is not clear which of them are sensitive to the impaired voice quality after laryngeal injury or surgery. In order to conduct meaningful voice research in pigs, it is critical to have standard functional voice outcome measures that can distinguish between normal and impaired voices.
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- - Genetic ataxias are caused by mutations in many genes, making diagnosis tricky; whole-exome sequencing (WES) has improved diagnosis but has an unclear limit on its success rate.
- - A study expanded from 76 to 260 patients analyzed both rare coding variations and larger genetic changes, finding a stable diagnostic detection rate of 47% in new cases, with a slight improvement in previously sequenced patients.
- - Overall, the combined results showed a 52% diagnostic rate, suggesting that while WES has advanced, it may still reach a plateau, indicating a need for more comprehensive genetic analyses to uncover the full spectrum of causes behind cerebellar ataxias.