[Effect of perindopril on indices of cardiac function and quality of life in patients with arterial hypertension in regard to age].

At present in the treatment of arterial hypertension the role of angiotensine converting enzyme inhibitors is significant. From this group the most special attention was attracted to peridopril-esbumin. High efficiency of this preparation has been corroborated by numerous controlled, multicentral investigations.

[Detection of latent disorders of coronary circulation and heart rhythm in ischemic heart disease patients by using psychoemotional loading].

A relationship between the emergence of ventricular arrhythmias and other signs of myocardial ischemia was assessed in 96 coronary patients on the basis of comparative results of the physical and psychoemotional stressful tests, and the nitroglycerin and aspirin tests. Ventricular rhythm disorders may develop in the course of mental exercise in some coronary patients with low hemodynamic values as the only manifestation of myocardial ischemia. Large-scale use of the mental stressful test is advocated for cardiologic medical institutions.

[Effect of tobanum on various functions of the heart in patients with ischemic heart disease and prospects for its clinical application].

In coronary patients with relatively intact myocardial function, tobanum increases physical stress tolerance and produces positive central hemodynamic shifts, while myocardial contractility is depressed insignificantly. In patients with low myocardial functional reserve, these parameters, on the contrary, deteriorate, particularly during exercise. Combined use of tobanum and corinfar in patients with impaired myocardial contractility controls cardio- and hemodynamic shifts and increases physical stress tolerance.

[Haptoglobin phenotype distribution in patients at high risk of developing myocardial infarct].

Haptoglobin (Hp) phenotyping was carried out in patients at risk for myocardial infarction. A highly significant increase in the incidence of the phenotype Hp 2-2 was demonstrated in the high-risk group, as compared to a group of normal subjects.

[Combined use of psychological and physical loading tests in the diagnosis of ischemic heart disease].

Reactions of heart ectopic activity in psychological exercise were similar to those in bicycle ergometry, but the values of pulse and arterial pressure increase were lower. The advantages of the psychological exercise test in detecting disorders of cardiac rhythm in patients, particularly in those hypersensitive to psychogenic effects, is noted. The importance of using psychological exercises in patients with high tolerance to physical exercises, by means of which latent forms of arrhythmias cannot always be detected, is pointed out.

[Study of ectopic cardiac activity under the effect of psychological stress].

Mental and emotional load consisting of several psychological tests was used in 35 patients with ischemic heart disease to disclose hazardous and latent forms of disorders of cardiac rhythm as possible forewarning of sudden death and to study the role of the psychological factor and stress situation in their origin. The reaction of extopic myocardial activity to the load proved different. In distinction to patients with functional cardiovascular disorders, patients with organic affections of the myocardium responded to the load by the appearance of extrasystoles during the load or by their greated frequency.