Immunomodulatory capacity of the local mesenchymal stem cells transplantation after severe skeletal muscle injury in female rats.

Context: Cell therapy technique with stem cells is a very attractive strategy for the treatment of muscle disorders.

Objective: The objective of this study was to investigate the mechanism of local transplantation of mesenchymal stem cells (MSCs) which could contribute to skeletal muscle healing.

Materials And Methods: Female rats were divided into three equal groups as the following: group 1, the negative control group (untreated group), group 2, sham-treated group, rats with muscle injuries involving volumetric muscle loss (VML) of adductor brevis muscle and injected locally with phosphate-buffered saline (PBS) 0.

Prenatal effects of transplacental exposure to ifosfamide in rats.

Ifosfamide is an alkylating chemotherapeutic agent that exhibits activity against a wide range of tumors. Exposure to such agent just prior to mating (preconception period) may have adverse effects on developing embryos. I investigated the rate of apoptosis and the histological changes in both placenta and developing fetal tissues after exposure to ifosfamide of young female rats before mating.

The effects of N-acetyl-L-cysteine on the female reproductive performance and nephrotoxicity in rats.

This study was designed to investigate whether the treatment with the N-acetyl-L-cysteine prior to the administration of chemotherapy drug would prevent from nephrotoxicity and the loss of reproductive performance induced from chemotherapy treatment. Female rats were divided into five equal groups of six each: 1/control group; 2/rats i.p administered saline solution; 3/rats i.

Evaluation of lower facial heights as related to different anthropometric measurements in dentate and completely edentulous subjects.

Objective: The aim was to compare two measurements of lower facial height (base of chin-subnasale and base of chin- tip of the nose) as related to different anthropometric measurements in dentate and completely edentulous subjects.

Method And Materials: This cross-sectional study was conducted on 132 male subjects (group 1 [G1], 120 dentate subjects; and group 2 [G2], 12 completely edentulous subjects). Base of chin-subnasale measurement (FM1), base of chin-tip of the nose measurement (FM2), Willis' measurement (FM3), glabella-subnasale measurement (FM4), length of the index finger measurement (AM1), and tip of thumb-tip of index finger measurement (AM2) of subjects of G1 and G2 were measured by using a modified caliper while the subjects in G1 closed in centric occlusion, and the subjects of G2 were asked to close the maxillary and mandibular complete dentures in centric relation.

Celery oil modulates DEHP-induced reproductive toxicity in male rats.

The objective of the study was to investigate the protective effect of Apium graveolens (AP) against di-(2-ethylhexyl) phthalate (DEHP)-induced testes injury in rats. Adult rats were divided into nine groups: (1) control group (no treatment); (2) corn oil (60 μg/kg body weight - bwt); (3) AP (50 μg/kg bwt); (4) 300 mg DEHP/kg bwt; (5) 500 mg DEHP/kg bwt; (6) 1000 mg DEHP/kg bwt; (7) 300 mg DEHP/kg bwt+AP; (8) 500 mg DEHP/kg bwt+AP; and (9) 1000 mg DEHP/kg bwt+AP. Oral administration of treatments was performed daily for 6 weeks.

Toxicological study of sodium selenite on fetal development and DNA fragmentation in liver cells of pregnant rats.

The present study was carried out to evaluate the effects of sodium selenite on fetal development and DNA in liver of rats. Pregnant rats were divided into three groups: control group, group treated orally with 5 µg Se/kg body wt. and group treated orally with 10 µg Se/kg body wt.