[An analysis of variance of the integration of the vascular and germinative testicular systems in the pathogenesis of infertility].

In 162 infertile patients and 404 rats an impact was evaluated of varicocele, cryptorchidism, epididymitis, prostatitis, obstruction of the deferent ducts and effects of the electromagnetic field on the amounts and volume of spermatogonia nuclei. Sertoli cells, Leydig's cells, the number and outer diameter of arterioles, capillaries and venules. The impact of the above illnesses is at its greatest in respect of the spermatogenic epithelium, with lesser effects being exerted on the parameters of the hemomicrocirculatory bed, the most measurable changes in which occur with microvessels of the venular link.

[The pathogenesis of infertility in men].

With the purpose of gaining insights into the general regularities and particular features of pathogenesis of sterility of urogenital genesis, we undertook the present studies on biopsy specimens of testes, epididymis, deferent ducts, prostate, spermogramme, blood plasma content of gonadotrophic and sex hormones in 162 patients with infertility of urogenital genesis, and in 412 rats. Infertility pathogenesis was found out to have two stages: compensatory-adaptive alterations and irreversible disorders. Infertility is believed to be a polyetiologic, monopathogenetic medical condition.

[The interaction of changes in the genitalia in the pathogenesis of sterility in men].

Alterations in testicular structures on the side of the pathologic process, contralateral testicle, epididymis, deferent duct, prostate, spermogramme, were found out to be related to the level of gonadotrophic and sex hormones in pathogenesis of infertility developing in varicocele, cryptorchidism, epididymitis, prostatitis, obstruction of the deferent duct, and action of low frequency electromagnetic field. The findings obtained will, we believe, help in diagnosing and prescribing the pathogenetically substantiated treatment.

[The interrelationship of changes in the vascular bed of the testes to the status of the spermogram in the pathogenesis of infertility].

Infertile marriage is a burning medical and social problem. In spite of this the pathogenesis of infertility in men is not at present fully understood. The present investigation was designed to study general regularities of interrelation between changes in vascular bed of the testis and state of spermogramme in the pathogenesis of infertility.

[Ultrastructural changes in the hemato-testicular barrier in the pathogenesis of infertility].

An ejaculate and biopsy specimen of the testes from 162 patients with infertility of different etiology were studied. General regularities were established of development of pathospermy on the ultrastructural level in diseases of urogenital genesis. Development of infertility appear to be conditioned by consecutive interrelated processes of changes in the structure of different components of the hemato-testicular barrier.