Publications by authors named "Malte Schwartz"
Article Synopsis
- - A neutered male Weimaraner exhibited progressive neurological symptoms such as fecal incontinence, lethargy, and cognitive decline, beginning at nearly 5 years old and leading to euthanasia at 6 years, 7 months due to worsening conditions.
- - MRIs revealed brain atrophy and white matter pathology, while immunolabeling found autofluorescent granules in various tissues, suggesting a link to a lysosomal storage disease affecting myelin and causing significant neuroinflammation.
- - Whole genome sequencing identified a specific mutation related to myelin gene function, indicating a genetic basis for the dog's neurological deterioration, characterized by abnormal myelin structures in the brain and optic nerve.
Objective: To determine the prevalence and clinical features of cryptogenic epilepsy among dogs.
Design: Retrospective case series.
Animals: 214 client-owned dogs with onset of epileptic seizures at ≥ 7 years of age.
A 9-year old female spayed Rottweiler was diagnosed with cryptogenic epilepsy and started on zonisamide monotherapy (8.3 mg/kg, PO, q 12 hr). Three weeks after the 1st dose of zonisamide the dog presented for vomiting, inappetence and icterus.
View Article and Find Full Text PDFPrevious studies on canine steroid-responsive meningitis-arteritis (SRMA) suggested that elevation of immunoglobulin A (IgA) concentrations in both serum and cerebrospinal fluid (CSF) is specific for SRMA throughout the different disease stages. Recent studies however have raised concerns about the value of this test. The purpose of this study was to investigate the diagnostic value of IgA concentration testing in paired CSF and serum samples.
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