Birthweight of children with isolated congenital heart disease-A sibling analysis study.

Objective: Congenital heart disease (CHD) is associated with decreased birthweight (BW) compared to population-based references. The aim of this study was to compare the BW of isolated CHD cases to their siblings, thus controlling for unknown and unmeasured confounders within the family.

Methods: All isolated CHD cases in the Leiden University Medical Center were included (2002-2019).