The use of serum paraoxonase-1 to assess inflammation in horses with colitis.

Background: Paraoxonase-1 (PON-1) has been suggested as a marker of inflammation and oxidative stress in horses and could potentially be used for prognostication in horses with colitis.

Objectives: Assessment of PON-1 in horses with colitis and comparison of two methods.

Methods: Serum PON-1 was measured by two methods (paraoxon and p-nitrophenyl acetate) in 161 horses with colitis and 57 controls.

Concentrations of neutrophil gelatinase-associated lipocalin are increased in serum and peritoneal fluid from horses with inflammatory abdominal disease and non-strangulating intestinal infarctions.

Background: Neutrophil gelatinase-associated lipocalin (NGAL) is produced in response to inflammation in horses, but it has not yet been investigated as a biomarker in horses with the abdominal disease.

Objectives: To investigate NGAL in serum and peritoneal fluid in horses with the abdominal disease.

Study Design: Retrospective clinical study.