Reduction of artifacts associated with missing data in coherent diffractive imaging.

Coherent diffractive imaging experiments often collect incomplete datasets containing regions that lack any measurements. These regions can arise because of beamstops, gaps between detectors, or, in tomography experiments, a missing wedge of data due to a limited sample rotation range. We describe practical and effective approaches to mitigate reconstruction artifacts by bringing uniqueness back to the phase retrieval problem.

Influence of study characteristics on harm estimates from randomised controlled trials in patients with inflammatory arthritis receiving biological or synthetic antirheumatic drugs: a meta-epidemiological study.

Objective: To examine the association between study characteristics and the harms reported in randomised controlled trials (RCTs) on biological and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) in patients with inflammatory arthritis (IA).

Methods: We searched MEDLINE for all Cochrane reviews and for systematic reviews published since April 2015. RCTs were eligible if they included patients with IA receiving b/tsDMARD, compared with any comparator arm.

The Associations between Father Involvement and Father-Daughter Relationship Quality on Girls' Experience of Social Bullying Victimization.

With much research into physical, cyber, and verbal bullying victimization, social bullying victimization is a type of victimization that can be hidden. Studies about Black father involvement have found involvement to be a buffer to adverse and risky behaviors of children, including different forms of victimization experienced by their daughters. This study examined one gap in the literature: the direct and potentially indirect associations between father involvement and father-child relationship quality on child reports of social bullying victimization among girls.

Complete alignment of a KB-mirror system guided by ptychography.

We demonstrate how the individual mirrors of a high-quality Kirkpatrick-Baez (KB) mirror system can be aligned to each other to create an optimally focused beam, through minimizing aberrations in the phase of the ptychographically reconstructed pupil function. Different sources of misalignment and the distinctive phase artifacts they create are presented via experimental results from the alignment of the KB mirrors at the NanoMAX diffraction endstation. The catalog of aberration artifacts can be used to easily identify which parameter requires further tuning in the alignment of any KB mirror system.

Reference shape effects on Fourier transform holography.

Soft-x-ray holography which utilizes an optics mask fabricated in direct contact with the sample, is a widely applied x-ray microscopy method, in particular, for investigating magnetic samples. The optics mask splits the x-ray beam into a reference wave and a wave to illuminate the sample. The reconstruction quality in such a Fourier-transform holography experiment depends primarily on the characteristics of the reference wave, typically emerging from a small, high-aspect-ratio pinhole in the mask.

[Physiotherapeutic Care of Adults with Neuromuscular Diseases - an Online Survey of Physiotherapists in the City Area of Munich].

Background And Aim: Physiotherapy has a key role in the symptomatic treatment of neuromuscular disorders (NMD). In the health care of adults with NMD, there may be intransparency of physiotherapy processes due, among other factors, to disciplinary interfaces. This study describes the current state of physiotherapeutic care for adults with NMD and examines the needs of physiotherapists in improving the quality of physiotherapeutic care.

Social media use, and fear of COVID-19 among Ghanaian university students: the moderating role of gender.

Background: COVID-19 and its associated social restrictive measures and lockdowns exacerbated the use of social media and other technological facilities for communication. This study, therefore, examined Ghanaian students' social media use and its relationship with fear of COVID-19, paying close attention to the moderating role of gender.

Methods: A correlational online survey was used to collect data from a purposive sample of 209 University students in June and July 2020.

Knowledge of developmental disabilities and referral sources among health workers in two Ghanaian hospitals.

Proper treatment of developmental disabilities requires health workers to have adequate knowledge of etiology and referral procedures. There is a dearth of research on knowledge of developmental disabilities among health workers in Ghana. The purpose of this study was to document knowledge about developmental disorders, causes, and referral procedures among health workers.

Parental experiences of having a child with CLN3 disease (juvenile Batten disease) and how these experiences relate to family resilience.

Background: CLN3 disease is a neurodegenerative condition presenting in the first decade of life typically leading to death in the third decade. The earliest symptom is rapidly progressive visual impairment followed by intellectual and motor impairments, epilepsy and behavioural disturbances. There are limited data on how the condition affects the family system or the role of family resilience in paediatric neurodegenerative diseases.

Fear of COVID-19: Psychological distress and coping among university students in Ghana.

The advent of the coronavirus pandemic has impacted the psychological well-being of many people. This study examined the relationship between fear of COVID-19, psychological distress (depression, anxiety, and stress) and coping strategies adopted by undergraduate students in Ghana. A sample of 209 students were recruited to complete online surveys on fear of COVID-19, psychological distress and coping strategies between June and July 2020.

Risk of harm in synthetic and biological intervention trials in patients with inflammatory arthritis: protocol for a metaepidemiological study focusing on contextual factors.

Introduction: Inflammatory arthritis (IA) conditions, including rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis, are characterised by inflammatory infiltration of the joints. Biological disease-modifying antirheumatic drugs (bDMARDs) and targeted synthetic disease-modifying antirheumatic drugs (tsDMARDs), respectively, reduce the effects of proinflammatory cytokines and immune cells to ameliorate disease. However, immunosuppression can be associated with high rates of serious adverse events (SAEs), including serious infections, and maybe an increased risk of malignancies and cardiovascular events.

Effects of Parenting by Lying in Childhood on Adult Lying, Internalizing Behaviors, and Relationship Quality.

Parenting by lying is a phenomenon in which parents lie to their children, usually for a positive goal, and has been the subject of new parenting research. This study tested the associations between parenting by lying in childhood, lying to parents in young adulthood, and parent-child relationship quality. Secondly, we examined the mechanisms through which these constructs were all related to internalizing behaviors in young adulthood, specifically-stress, anxiety and depressive symptoms.

Multi-wavelength phase retrieval for coherent diffractive imaging.

Phase retrieval is a numerical procedure concerned with the recovery of a complex-valued signal from measurements of its amplitude. We describe a generalization of this method for multi-wavelength data acquired in a coherent diffractive imaging experiment. It exploits the wavelength-dependent scaling of the support domain to recover separate reconstructions for each wavelength, providing new possibilities for coherent diffractive imaging experiments.

Pain trajectories of dorsomedial prefrontal intermittent theta burst stimulation versus sham treatment in depression.

Background: Prefrontal repetitive transcranial magnetic stimulation is an established add-on treatment for major depressive disorder and is increasingly feasible with protocols of short duration, such as intermittent theta burst stimulation (iTBS). The most common and limiting side effect is pain at the site of application. Our objective was to investigate how pain develops over time in patients with depression receiving iTBS compared to sham stimulation.

Singleshot polychromatic coherent diffractive imaging with a high-order harmonic source.

Singleshot polychromatic coherent diffractive imaging is performed with a high-intensity high-order harmonic generation source. The coherence properties are analyzed and several reconstructions show the shot-to-shot fluctuations of the incident beam wavefront. The method is based on a multi-step approach.

Longitudinal Relationships Between Parent Factors, Children's Bullying, and Victimization Behaviors.

Longitudinal data from NICHD Study of Early Child Care and Youth Development tested direct, indirect and reciprocal effects of maternal depressive symptoms, stress/support factors on child bullying and peer victimization through mother-child relationship quality at grades 3, 5, 6. Data from 828 mother-child dyads indicated small significant effects of some hypothesized pathways, including a small direct effect of maternal depressive symptoms at grade 3 on peer victimization at grade 5, but not on bullying behaviors. Mother-child relationship quality at grade 5 negatively predicted bullying at grade 6, but not peer victimization.

Single-shot extreme-ultraviolet wavefront measurements of high-order harmonics.

We perform wavefront measurements of high-order harmonics using an extreme-ultraviolet (XUV) Hartmann sensor and study how their spatial properties vary with different generation parameters, such as pressure in the nonlinear medium, fundamental pulse energy and duration as well as beam size. In some conditions, excellent wavefront quality (up to λ/11) was obtained. The high throughput of the intense XUV beamline at the Lund Laser Centre allows us to perform single-shot measurements of both the full harmonic beam generated in argon and individual harmonics selected by multilayer mirrors.

Functional validation of ABHD12 mutations in the neurodegenerative disease PHARC.

ABHD12 mutations have been linked to neurodegenerative PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and early-onset cataract), a rare, progressive, autosomal, recessive disease. Although ABHD12 is suspected to play a role in the lysophosphatidylserine and/or endocannabinoid pathways, its precise functional role(s) leading to PHARC disease had not previously been characterized. Cell and zebrafish models were designed to demonstrate the causal link between an identified new missense mutation p.

Proteomic Analysis of a Poplar Cell Suspension Culture Suggests a Major Role of Protein S-Acylation in Diverse Cellular Processes.

S-acylation is a reversible post-translational modification of proteins known to be involved in membrane targeting, subcellular trafficking, and the determination of a great variety of functional properties of proteins. The aim of this work was to identify S-acylated proteins in poplar. The use of an acyl-biotin exchange method and mass spectrometry allowed the identification of around 450 S-acylated proteins, which were subdivided into three major groups of proteins involved in transport, signal transduction, and response to stress, respectively.

Cellular High-Energy Cavitation Trauma - Description of a Novel In Vitro Trauma Model in Three Different Cell Types.

The mechanisms involved in traumatic brain injury have yet to be fully characterized. One mechanism that, especially in high-energy trauma, could be of importance is cavitation. Cavitation can be described as a process of vaporization, bubble generation, and bubble implosion as a result of a decrease and subsequent increase in pressure.

Lipopeptide biosynthesis in Pseudomonas fluorescens is regulated by the protease complex ClpAP.

Background: Lipopeptides (LP) are structurally diverse compounds with potent surfactant and broad-spectrum antibiotic activities. In Pseudomonas and other bacterial genera, LP biosynthesis is governed by large multimodular nonribosomal peptide synthetases (NRPS). To date, relatively little is known about the regulatory genetic network of LP biosynthesis.

APP: an Automated Proteomics Pipeline for the analysis of mass spectrometry data based on multiple open access tools.

Background: Mass spectrometry analyses of complex protein samples yield large amounts of data and specific expertise is needed for data analysis, in addition to a dedicated computer infrastructure. Furthermore, the identification of proteins and their specific properties require the use of multiple independent bioinformatics tools and several database search algorithms to process the same datasets. In order to facilitate and increase the speed of data analysis, there is a need for an integrated platform that would allow a comprehensive profiling of thousands of peptides and proteins in a single process through the simultaneous exploitation of multiple complementary algorithms.

Recording oscillations of sub-micron size cantilevers by extreme ultraviolet Fourier transform holography.

We recorded the fast oscillation of sub-micron cantilevers using time-resolved extreme ultraviolet (EUV) Fourier transform holography. A tabletop capillary discharge EUV laser with a wavelength of 46.9 nm provided a large flux of coherent illumination that was split using a Fresnel zone plate to generate the object and the reference beams.

Quantitative proteomics reveals that plasma membrane microdomains from poplar cell suspension cultures are enriched in markers of signal transduction, molecular transport, and callose biosynthesis.

The plasma membrane (PM) is a highly dynamic interface that contains detergent-resistant microdomains (DRMs). The aim of this work was to determine the main functions of such microdomains in poplar through a proteomic analysis using gel-based and solution (iTRAQ) approaches. A total of 80 proteins from a limited number of functional classes were found to be significantly enriched in DRM relative to PM.