Publications by authors named "Mallory Brayer"
Objectives: In this study, we aim to investigate whether therapeutic ultrasound can modulate the release of melatonin from the pineal gland-either increasing or decreasing its levels-and to assess the safety of this technique. This research could address a significant clinical need by providing a noninvasive method to potentially regulate sleep and circadian rhythms through the targeted modulation of melatonin.
Methods: Rat pineal glands were placed in a well with a Krebs Ringer Buffer solution.
Impeding or reducing human amylin aggregation and/or its toxicity can be key to preventing pancreatic islet amyloidosis and β-cell loss in patients with Type 2 Diabetes Mellitus (T2DM). Here, Punica granatum (pomegranate) peel, Sideritis raeseri (ironwort) and Aronia melanocarpa (chokeberry) leaf extracts, were tested for their novel anti-aggregative and antitoxic properties in human amylin (hIAPP) treated rat pancreatic insulinoma (INS) cells. The protein aggregation (Th-T) assay revealed an inhibitory trend of all three plant extracts against amylin aggregates.
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- * NAGS deficiency (NAGSD) is a rare urea cycle disorder that can be effectively treated with N-carbamylglutamate (NCG), and the study focused on factors that could contribute to the rarity of NAGSD, such as low genomic variation and alternative NAG sources.
- * Researchers discovered a novel regulatory element in the NAGS gene and identified new regulatory elements in other urea cycle genes, which