Oxidative stress during acute respiratory exacerbations in cystic fibrosis.

Background: Patients with cystic fibrosis experience chronic systemic oxidative stress. This is coupled with chronic inflammation of the lung involving bronchial polymorphonuclear neutrophil accumulation and activation. We hypothesised that, during periods of acute respiratory exacerbation, free radical activity and consequent damage would be most marked and that intensive treatment of the infection would result in improvement towards values found during stable periods.

Managing for total quality in a large laboratory. Some examples.

A large laboratory, processing more than 30,000 requisitions every 24 hours, provides a unique opportunity to document the value of selected approaches to managing for total quality. Proficiency test errors are an important subset of this database. They can provide a quality control manager with essential diagnostic information if data are analyzed in a systematic fashion.

Normalization of the dexamethasone suppression test at discharge from hospital. Its prognostic value.

Fourteen patients with RDC diagnosis of primary, endogenous, major depressive disorder were studied in an inpatient setting. All were non-suppressors on the Dexamethasone Suppression Test on admission to hospital and were retested at discharge. Over 70% of patients continued to be non-suppressors at discharge, when in clinical remission.