Publications by authors named "Malligurki Raghurama Rukmani"
Article Synopsis
- Multiple system atrophy (MSA) is a serious neurodegenerative disorder that significantly disrupts sleep, impacting the overall quality of life for patients and serving as a negative prognostic factor.
- The study investigated sleep disturbances in 60 probable MSA patients in India, revealing a high prevalence of issues like REM behavior disorder, poor sleep quality, and insomnia, with poor sleep correlating to disease severity.
- Findings suggest that the type of MSA (parkinsonian vs. cerebellar) does not notably affect sleep parameters, but the duration of REM behavior disorder is linked to worse sleep quality and disease progression.
Background: Multiple system atrophy is an adult-onset, sporadic, neurodegenerative disorder with parkinsonian (MSA-P) and cerebellar (MSA-C) subtypes.
Objective: We aimed to elucidate differences in prognostic factors between MSA subtypes.
Methods: The study population comprised 45 probable MSA patients (MSA-P = 22; MSA-C = 23) and 45 healthy controls.
Introduction: In frontotemporal dementia (FTD) and Alzheimer's disease (AD), central autonomic structures get affected early. An insight into autonomic functions in these patients is likely to be of diagnostic importance and thus help in prognosticating and also probably explain unexplained sudden death in some of these patients.
Objectives: The objective of this study is to identify autonomic dysfunction prevailing in patients.
Background: Attention deficit/hyperactivity disorder (ADHD) is a common childhood neuropsychiatric disorder. Autonomic nervous system plays a vital role in attention, self-regulation, emotional stability and social affiliation, which are affected in ADHD. The prefrontal cortex, which is vital for attention, motor control, emotional regulation and higher order autonomic control, is hypofunctional in ADHD.
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