Role of AIM2 and cGAS-STING signaling in high fat high carbohydrate diet-induced gut dysbiosis associated neurodegeneration.

Aims: Gut dysbiosis modulates CNS complications and cognitive decline through the gut-brain axis. The study aims to investigate the molecular mechanisms involved in gut dysbiosis-associated cognitive changes and the potential effects of probiotics in high fat-high carbohydrate diet-induced gut dysbiosis-associated neurodegeneration.

Materials And Methods: We used high fat, high-carbohydrate diet (HFHCD) and high-fat diet (HFD) to induce gut dysbiosis-associated neurodegeneration in C57BL/6 mice.

Electrochemical sensing of dopamine using nanostructured silver chromate: Development of an IoT-integrated sensor.

Dopamine, one of the most important neurotransmitters, plays a crucial role in the functions of human metabolism, as well as the cardiovascular, central nervous and hormonal systems. This study focuses on the synthesis of nanostructured silver chromate and their application in dopamine sensing. The nanoparticles were synthesized using a complexation-mediated route using aminosalicylic acid as a stabilizer, resulting in uniform particles ranging from 3 to 15 nm in size.

Semi-infinite Simple Exclusion Process: From Current Fluctuations to Target Survival.

The symmetric simple exclusion process (SEP), where diffusive particles cannot overtake each other, is a paradigmatic model of transport in the single-file geometry. In this model, the study of currents has attracted a lot of attention, but so far most results are restricted to two geometries: (i) a finite system between two reservoirs, which does not conserve the number of particles but reaches a nonequilibrium steady state, and (ii) an infinite system which conserves the number of particles but never reaches a steady state. Here, we obtain an expression for the full cumulant generating function of the integrated current in the important intermediate situation of a semi-infinite system connected to a reservoir, which does not conserve the number of particles and never reaches a steady state.

Electrocatalytic efficiency of carbon nitride supported gold nanoparticle based sensor for iodide and cysteine detection.

Extensive investigations are being conducted on gold nanoparticles focusing on their applications in biosensors, laser phototherapy, targeted drug delivery and bioimaging utilizing advanced detection techniques. In this work, an electrochemical sensor was developed based on graphite carbon nitride supported gold nanoparticles. Carbon nitride supported gold nanoparticles (Au-CN) was synthesized by applying a deposition-precipitation route followed by a chemical reduction technique.

Probiotic treatment improves post-traumatic stress disorder outcomes in mice.

Post-traumatic stress disorder (PTSD) is a mental disorder resulting from traumatic events which are characterized primarily by anxiety and depressive disorder. In this study, we determine the role of gut bacteria in PTSD. PTSD-like symptoms were produced by single prolonged stress (SPS).

Investigation of Host-Guest Inclusion Complex of Mephenesin with α-Cyclodextrin for Innovative Application in Biological System.

The goal of this study was to use coevaporation to look into how polyether compounds like mephenesin (MEP) can be encapsulated into the host molecule α-cyclodextrin's nanohydrophobic cage. Fourier transform infrared spectroscopy (FT-IR) investigations, powder X-ray diffraction (PXRD), and H NMR were among the spectroscopic techniques used to describe the inclusion complex. Additionally, Job's plot has been utilized to illustrate how MEP is encapsulated with α-cyclodextrin (α-CD) at a 1:1 molar ratio.

A review on advancements in feature selection and feature extraction for high-dimensional NGS data analysis.

Recent advancements in biomedical technologies and the proliferation of high-dimensional Next Generation Sequencing (NGS) datasets have led to significant growth in the bulk and density of data. The NGS high-dimensional data, characterized by a large number of genomics, transcriptomics, proteomics, and metagenomics features relative to the number of biological samples, presents significant challenges for reducing feature dimensionality. The high dimensionality of NGS data poses significant challenges for data analysis, including increased computational burden, potential overfitting, and difficulty in interpreting results.

The anxiolytic effects of cannabinoids: A comprehensive review.

Cannabinoids, notably cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC), have emerged as promising candidates for anxiety disorder treatment, supported by both preclinical and clinical evidence. CBD exhibits notable anxiolytic effects with a favourable safety profile, though concerns regarding mild side effects and drug interactions remain. Conversely, THC, the primary psychoactive compound, presents a range of side effects, underscoring the importance of careful dosage management and individualized treatment strategies.

Maximizing the impact of community outreach and engagement at US cancer centers.

In 2016, the National Cancer Institute-designated cancer centers funding opportunity was expanded to require community outreach and engagement (COE), with explicit attention to cancer inequities, community engagement, and implementation science in the centers' catchment areas. Resource limitations constrain these activities, and we conducted a qualitative study to understand what COE leaders see as critical needs and supports to increase impact. In the spring of 2021, we interviewed leaders from 56 of 64 cancer centers with COE programs and analyzed the data using a reflexive, thematic approach.

Lipid Droplets and Neurodegeneration.

Energy metabolism in the brain has been considered one of the critical research areas of neuroscience for ages. One of the most vital parts of brain metabolism cascades is lipid metabolism, and fatty acid plays a crucial role in this process. The fatty acid breakdown process in mitochondria undergoes through a conserved pathway known as β-oxidation where acetyl-CoA and shorter fatty acid chains are produced along with a significant amount of energy molecule.

Current fluctuations in a partially asymmetric simple exclusion process with a defect particle.

We study an exclusion process on a ring comprising a free defect particle in a bath of normal particles. The model is one of the few integrable cases in which the bath particles are partially asymmetric. The presence of the free defect creates localized or shock phases according to parameter values.

A review of the genus Plutodes Guene (Geometridae: Ennominae) from India with description of one new species.

In the present paper, we discuss the taxonomy of 11 species of Plutodes Guene, [1858], collected from different regions of India, including description of one new species, P. quadratus sp. nov.

Investigation of intermolecular interactions of l-Valine and l-Phenylalanine with muscle relaxant drug mephenesin molecule prevalent in aqueous solution by various physico-chemical methods at T=298.15K-313.15K.

A complete chemical analysis of significant intermolecular interactions of l-Valine (L-Val) and l-Phenylalanine (L-Phe) with Mephenesin (MEPN) molecules in aqueous solution has been studied by different physicochemical methodologies at various temperatures ( = 298.15 K-313.15 K at an interval of 5 K) and concentrations (0.

Harvesting marine plastic pollutants-derived renewable energy: A comprehensive review on applied energy and sustainable approach.

The inevitable use of plastics in the existing standard of life makes its way to ecosystems, predominantly into the marine ecosystem. Recent research on energy recycling from marine discarded plastics through biological, chemical, and thermal processes is summarized, which degrade plastic debris and transform it into energy-efficient products. In a system-oriented approach, different boundaries like carbon efficiency, global warming potential, cumulative energy demand, and cost of the product have been evaluated.

Implementation of evidence-based primary cancer prevention interventions in MA community health centers: an explanatory sequential mixed methods study.

Background: More than half of cancers could be prevented by employing evidence-based interventions (EBIs), including prevention interventions targeting nutrition, physical activity, and tobacco. Federally qualified health centers (FQHCs) are the primary source of patient care for over 30 million Americans - making them an optimal setting for ensuring evidence-based prevention that advances health equity. The aims of this study are to (1) determine the degree to which primary cancer prevention EBIs are being implemented within Massachusetts FQHCs and (2) describe how these EBIs are implemented internally and via community partnerships.

Label-Free Detection of Epinephrine Using Flower-like Biomimetic CuS Antioxidant Nanozymes.

A biosensor comprising crystalline CuS nanoparticles (NPs) was synthesized via a one-step simple coprecipitation route without involvement of a surfactant. The powder X-ray diffraction method has been used to evaluate the crystalline nature and different phases consist of the formation of CuS NPs. Mainly hexagonal unit cells consist of the formation of CuS NP unit cells.

Dynamical fluctuations in the Riesz gas.

We consider an infinite system of particles on a line performing identical Brownian motions and interacting through the |x-y|^{-s} Riesz potential, causing the overdamped motion of particles. We investigate fluctuations of the integrated current and the position of a tagged particle. We show that for 0 View Article and Find Full Text PDF

A scalable unsupervised learning of scRNAseq data detects rare cells through integration of structure-preserving embedding, clustering and outlier detection.

Single-cell RNA-seq analysis has become a powerful tool to analyse the transcriptomes of individual cells. In turn, it has fostered the possibility of screening thousands of single cells in parallel. Thus, contrary to the traditional bulk measurements that only paint a macroscopic picture, gene measurements at the cell level aid researchers in studying different tissues and organs at various stages.

Associations of HIV and iron status with gut microbiota composition, gut inflammation and gut integrity in South African school-age children: a two-way factorial case-control study.

Background: Human immunodeficiency virus (HIV) and iron deficiency (ID) affect many African children. Both HIV and iron status interact with gut microbiota composition and related biomarkers. The study's aim was to determine the associations of HIV and iron status with gut microbiota composition, gut inflammation and gut integrity in South African school-age children.

Implementation of evidence-based primary cancer prevention interventions in MA community health centers: an explanatory sequential mixed methods study.

Background More than half of cancers could be prevented by employing evidence-based interventions (EBIs), including prevention interventions targeting nutrition, physical activity, and tobacco. Federally qualified health centers (FQHCs) are the primary source of patient care for over 30 million Americans - making them an optimal setting for ensuring evidence-based prevention that advances health equity. The aims of this study are to: 1) determine the degree to which primary cancer prevention EBIs are being implemented within Massachusetts FQHCs and 2) describe how these EBIs are implemented internally and via community partnerships.

Future prospects and recent developments of polyvinylidene fluoride (PVDF) piezoelectric polymer; fabrication methods, structure, and electro-mechanical properties.

Polyvinylidene fluoride (PVDF) is a favorite polymer with excellent piezoelectric properties due to its mechanical and thermal stability. This article provides an overview of recent developments in the modification of PVDF fibrous structures and prospects for its application with a major focus on energy harvesting devices, sensors and actuator materials, and other types of biomedical engineering and devices. Many sources of energy harvesting are available in the environment, including waste-heated mechanical, wind, and solar energy.

Organic molecule functionalized lead sulfide hybrid system for energy storage and field dependent polarization performances.

A wet chemical route is reported for synthesising organic molecule stabilized lead sulfide nanoparticles. The dielectric capacitance, energy storage performances and field-driven polarization of the organic-inorganic hybrid system are investigated in the form of a device under varying temperature and frequency conditions. The structural analysis confirmed the formation of the monoclinic phase of lead sulfide within the organic network.

Electrical response of organic molecule supported preformed and formed antimony sulfide nanoparticles under frequency conditions.

A complexation route mediated synthesis of orthorhombic antimony sulfide nanoparticles is described in this report where uniformly distributed particles within the size range of 2-12 nm are stabilized within the aniline matrix. The organic-inorganic hybrid system was investigated for dielectric capacitance and electric field-induced polarization performances under varying temperature and frequency conditions. The AC-conductivity revealed a correlated barrier hopping conduction mechanism in the hybrid system.

Exact Solution of the Macroscopic Fluctuation Theory for the Symmetric Exclusion Process.

We present the first exact solution for the time-dependent equations of the macroscopic fluctuation theory (MFT) for the symmetric simple exclusion process by combining a generalization of the canonical Cole-Hopf transformation with the inverse scattering method. For the step initial condition with two densities, we obtain exact and compact formulas for the optimal density profile and the response field that produce a required fluctuation, both at initial and final times. The large deviation function of the current is derived and coincides with the formula obtained previously by microscopic calculations.

In-vitro viability of bone scaffolds fabricated using the adaptive foam reticulation technique.

The adaptive foam reticulation technique combines the foam reticulation and freeze casting methodologies of fabricating bone reparative scaffolds to offer a potential alternative to autografts. For the first time this paper studies the effect of processing on the mechanical properties and in-vitro cell growth of controllably generating a hierarchical structure of macro- (94 ± 6 to 514 ± 36 μm) and microporosity (2-30 μm) by the inclusion of camphene as a porogen during processing. Scaffolds were produced with porogen additions of 0-25 wt%.