Two case reports of biliary stent infections by extensively drug-resistant Escherichia coli carrying bla at a tertiary-care hospital in West Bengal, India.

Background: Rising antimicrobial resistance (AMR) is an acute public health emergency impeding the clinical efficacy of surgical interventions. Biliary stent placement is one of the routine surgical procedures that rarely lead to infections that are empirically managed by broad-spectrum β-lactams and fluoroquinolones. Critical priority pathogens, such as carbapenem-resistant Escherichia coli challenge treatment outcomes and infection prevention.

Challenges in "probing spectroscopic probes" for noninvasive simultaneous disease diagnosis.

Noninvasive diagnosis of human diseases relies on the detection of molecular markers (probes) in a painless manner. Although extrinsic and intrinsic molecular markers are often used, intrinsic disease probes (molecular markers) are preferable because they are naturally present in our body, and deviation in their concentration from normal levels clearly indicates anomalies in human bodies, that is, diseases. In this study, we report noninvasive spectroscopic measurements of total haemoglobin (Hb), bilirubin, and the ratio of oxy- and deoxyhaemoglobin as disease markers for anaemia, jaundice, and oxygen deficiency, respectively, using a meticulously designed optical fibre probe.

Design of Flavonoid-Based Lipid Domains as Fusion Inhibitors to Efficiently Block Coronavirus and Other Enveloped Virus Infection.

Developing a broad-spectrum antiviral is imperative in light of the recent emergence of recurring viral infections. The critical role of host-virus attachment and membrane fusion during enveloped virus entry is a suitable target for developing broad-spectrum antivirals. A new class of flavonoid-based fusion inhibitors are designed to alter the membrane's physical properties.

Inguinal hernia mesh infections: Chronic challenges, atypical pathogens and lessons in sterilisation.

Chronic mesh infections after inguinal hernia repair present significant clinical challenges due to biofilm-mediated resistance, involvement of multidrug-resistant and atypical pathogens, and gaps in preventive strategies. Our case series of four patients highlights critical research gaps, including the overlooked role of atypical pathogens such as , diagnostic challenges in detecting slow-growing or resistant organisms and perioperative sterilisation lapses, especially inconsistent Glutaraldehyde use during late-day operations. Many patients suffered with persistent sinuses and recurrent hernias months after surgery.

Outcomes of Radical Radiotherapy (RT) or Chemoradiotherapy (CRT) in Surgically Inoperable Advanced Oral Cavity Cancer: A Single Center Experience.

Background: Patients with locally advanced, surgically unresectable oral squamous cell cancers (SU-OSCC) are often treated with palliative intent. There is limited information on the outcomes of radical intent treatment with radiotherapy (RT) or chemoradiotherapy (CRT).

Methods: We retrospectively examined patients with Stage III/IV previously untreated SU-OSCC treated definitively from 2011 to 2021 in a single institution with RT or CRT with or without neoadjuvant chemotherapy (NACT).

Teratocarcinosarcoma of the nasal cavity: challenges in the clinico-pathologic perspectives.

Objective: Clinicopathologic illustration of sinonasal teratocarcinosarcoma (SNTCS) in a middle-aged man, highlighting the difficulties and challenges encountered during surgical intervention, histopathologic diagnosis, and its overall management.

Methodology: Case report and literature review.

Results: A 40-year-old man having recurrent epistaxis for three months presented with a dark-colored protruding polypoid nasal mass.

Association of social vulnerability and depression incidence post intracerebral haemorrhage: a cohort study.

Objectives: Survivors of intracerebral haemorrhage (ICH) are at high risk of incident depression, which is modified by social determinants of health (SDOH) and associated with worse functional outcomes. We sought to determine the role of prestroke SDOH in depression incidence after ICH to better characterise post-ICH outcomes.

Study Design: We analysed data from a cohort study of ICH survivors without prestroke depression, presenting at Massachusetts General Hospital between 2006 and 2017.

De Novo Design of Lipopeptide-Based β-Sheet-Like Self-Assemblies: A Strategy to Develop Fusion Inhibitors as Broad-Spectrum Antivirals.

The recent surge in emerging viral infections warrants the design of broad-spectrum antivirals. We aim to develop a lead molecule that targets a common biochemical feature of many enveloped viruses, membrane fusion. To achieve the broad-spectrum ability, instead of targeting the fusion machinery, we plan to modulate the physicochemical properties of the host and viral membranes to block fusion.

Bicontinuous Nanoparticles from Spontaneous Self-Assembly of Block Copolymer Prodrug in Aqueous Medium for Potential Cancer Therapy.

Despite having several advantages, bicontinuously structured polymeric nanoparticles (BSPNPs) are far less explored in the field of controlled drug delivery owing to the requirement of complex precursor copolymers and the associated multistep synthetic procedures. In this work, we report the synthesis of a redox-sensitive diblock copolymer (P1), which was subsequently utilized to prepare doxorubicin (DOX) containing a pH-labile prodrug (P2). P1 and P2 spontaneously self-assembled in aqueous media above their critical aggregation concentration, forming micellar nanoparticles with rare bicontinuous morphology that promotes loading of both hydrophobic and hydrophilic cargoes in different compartments.

Rank-expanding satellites, Whitehead doubles, and Heegaard Floer homology.

We show that a large class of satellite operators are rank-expanding; that is, they map some rank-one subgroup of the concordance group onto an infinite linearly independent set. Our work constitutes the first systematic study of this property in the literature and partially affirms a conjecture of the second author and Pinzón-Caicedo. More generally, we establish a Floer-theoretic condition for a family of companion knots to have infinite-rank image under satellites from this class.

Magnetically Propelled Microrobots toward Photosynthesis of Green Ammonia from Nitrates.

Ammonia (NH₃) production is a critical industrial process, as ammonia is a key component in fertilizers, essential for global agriculture and food production. However, the current method of synthesizing ammonia, the Haber-Bosch process, is highly energy-intensive, and relies on fossil fuels, contributing substantially to greenhouse gas emissions. Moreover, the centralized nature of the Haber-Bosch process limits its accessibility in remote or resource-limited areas.

Serotonin acts through multiple cellular targets during an olfactory critical period.

Serotonin (5-HT) modulates early development during critical periods when experience drives heightened levels of plasticity in neurons. Here, we investigate the cellular mechanisms by which 5-HT modulates critical period plasticity (CPP) in the olfactory system of . We first demonstrate that 5-HT is necessary for experience-dependent structural plasticity in response to chronic CO exposure and can re-open the critical period long after it normally closes.

Methods to analyze the mitochondrial unfolded protein response (UPR).

The mitochondrial unfolded protein response (UPR) is a mitochondria-to-nuclear signaling pathway that mediates the transcription of genes required to maintain mitochondrial function during development as well as during aging. In this chapter, we describe the approaches and techniques that we and others have used to elucidate the mechanism(s) by which cells detect mitochondrial stress or dysfunction and communicate with the nucleus to induce transcription of a protective stress response. We also describe approaches to evaluate the impact of UPR activation on mitochondrial function and mitochondrial biogenesis including imaging-based approaches as well as approaches to evaluate mitochondrial genome (mtDNA) copy number.

UK Foot and Ankle Thromboembolism (UK-FATE).

Aims: Venous thromboembolism (VTE) is a potential complication of foot and ankle surgery. There is a lack of agreement on contributing risk factors and chemical prophylaxis requirements. The primary outcome of this study was to analyze the 90-day incidence of symptomatic VTE and VTE-related mortality in patients undergoing foot and ankle surgery and Achilles tendon (TA) rupture.

Dual stimuli-responsive biotinylated polymer-drug conjugate for dual drug delivery.

Stimuli-responsive nanoscale polymer-drug conjugates are one of the most promising alternatives in the realm of advanced therapeutics, rendering several characteristics such as spatio-temporal control over drug release, reduced off-target toxicity, enhanced bioavailability, and longer blood circulation time of the drug. Fostered by the aforementioned conceptualization, our quest to develop an ideal polymer-drug conjugate has originated the present investigation of developing a reactive oxygen species (ROS) and esterase-responsive self-assembled polymer-drug (chlorambucil, CBL) conjugate with biotin pendants (DP2) for cancer cell targeting, surrogating another antineoplastic drug, doxorubicin (DOX) physical encapsulation (DP2@DOX). The ROS and esterase trigger not only released the covalently stitched CBL but also resulted in DOX release by dismantling the amphiphilic balance of the nanoaggregates.

Deciphering Electrocatalytic Hydrogen Production in Water Through a Bioinspired Water-Stable Copper(II) Complex Adorned with (NS)-Donor Sites.

Electrocatalytic hydrogen production stands as a pivotal cornerstone in ushering the revolutionary era of the hydrogen economy. With a keen focus on emulating the significance of hydrogenase-like active sites in sustainable H generation, a meticulously designed and water-stable copper(II) complex, [Cl-Cu-L]ClO, featuring the N,S-type ligand, L (2,2'-((butane-2,3-diylbis(sulfanediyl))bis(methylene))dipyridine), has been crafted and assessed for its prowess in electrocatalytic H production in water, leveraging acetic acid as a proton source. The molecular catalyst, adopting a square pyramidal coordination geometry, undergoes -Cl substitution by HO during electrochemical conditions yielding [HO-Cu-L] as the true catalyst, showcases outstanding activity in electrochemical proton reduction in acidic water, achieving an impressive rate of 241.

Successful Treatment of Central Retinal Artery Occlusion With Tissue Plasminogen Activator Followed by Recurrent Retinal Ischemia.

To describe the use of intra-arterial tissue plasminogen activator (tPA) to treat central retinal artery occlusion (CRAO). A case and its findings were analyzed. A 45-year-old man diagnosed with a CRAO and had cerebral angiography and treatment with intra-arterial tPA.

Supramolecular-platform-assisted selective recognition of uric acid with high sensitivity microenvironment modulation of a self-assembled probe.

This report demonstrates a unique route for translating a non-responsive fluorophore into a responsive one to optically recognize uric acid (UA) in physiological-mimicking conditions. The explicit 'turn ON-turn OFF' fluorescence switching upon sequential disaggregation-reaggregation of the self-aggregated 3,3'-bisindolyl(phenyl)methane molecules materializes a straightforward, trouble-free supramolecular UA sensing platform.

p/n-Type Polyimide Covalent Organic Frameworks for High-Performance Cathodes in Sodium-Ion Batteries.

Covalent organic frameworks (COFs) are viewed as promising organic electrode materials for metal-ion batteries due to their structural diversity and tailoring capabilities. In this work, firstly using the monomers N,N,N',N'-tetrakis(4-aminophenyl)-1,4-phenylenediamine (TPDA) and terephthaldehyde (TA), p-type phenylenediamine-based imine-linked TPDA-TA-COF is synthesized. To construct a bipolar redox-active, porous and highly crystalline polyimide-linked COF, i.

Aggregation Induced Emission-Based Covalent Organic Frameworks for High-Performance Optical Wireless Communication.

Here, we report the first utilization of covalent organic frameworks (COFs) in optical wireless communication (OWC) applications. In the solid form, aggregation-induced emission (AIE) luminogen often shows promising emissive characteristics that augment radiative decays and improve fluorescence. We have synthesized an through the Knoevenagel condensation reaction by taking advantage of the ability to carefully design and alter the COF structure by integrating an AIE luminogen with linear building blocks.

Influence of social media on health-related decision-making among adults attending an outpatient department of a tertiary care centre in India: A cross-sectional analytical study.

Background Social media platforms, especially Facebook and WhatsApp, can spread public health information effectively. We aimed to estimate the influence of health-related messages circulated through these social media platforms on health-related decision-making and its associated factors. Methods We did a cross-sectional analytical study among adults (aged >18 years) who visited the outpatient department of a tertiary care hospital in suburban West Bengal, during July-September 2021.