Management of stable coronary artery disease and atrial fibrillation with anti-thrombotic therapy: A systematic review and meta-analysis.

Introduction: Long term management of patients with stable coronary artery disease of >1 year after myocardial infarction (MI) or percutaneous coronary intervention and atrial fibrillation is unclear. Current guidelines recommend using oral anti-coagulation (OAC) alone although the recommendation is weak and there is low quality evidence. Two new randomized control trials (RCTs) were published recently.

Artificial intelligence (AI) real-time detection vs. routine colonoscopy for colorectal neoplasia: a meta-analysis and trial sequential analysis.

Goals And Background: Studies analyzing artificial intelligence (AI) in colonoscopies have reported improvements in detecting colorectal cancer (CRC) lesions, however its utility in the realworld remains limited. In this systematic review and meta-analysis, we evaluate the efficacy of AI-assisted colonoscopies against routine colonoscopy (RC).

Study: We performed an extensive search of major databases (through January 2021) for randomized controlled trials (RCTs) reporting adenoma and polyp detection rates.

The role of the A-cations in the polymorphic stability and optoelectronic properties of lead-free ASnI perovskites.

Tin-based ASnI3 perovskites have been considered excellent candidates for lead-free perovskite solar cell applications; however, our atomistic understanding of the role of the A-cations, namely, CH3NH3 (methylammonium, MA), CH3PH3 (methylphosphonium, MP) and CH(NH2)2 (formamidinium, FA), in the physical chemistry properties is far from satisfactory. For the first time, we report a density functional theory investigation of the MPSnI3 perovskite and non-perovskite phases as well as their comparison with the MASnI3 and FASnI3 phases, where we considered the role of the A-cation orientations in the structural stability of the ASnI3 phases. The orthorhombic structure is the most stable studied phase, which agrees with experimentally reported phase-transition trends.

Thromboprophylaxis for orthopedic surgery; An updated meta-analysis.

Background: Venous thromboembolism (VTE) is a serious complication of orthopedic surgery. Low molecular weight heparin (LMWH) has been the standard of care for thromboprophylaxis in this population. However, direct oral anticoagulants (DOACs) are increasingly being used as alternatives.

Direct oral anticoagulant versus low-molecular-weight heparin for treatment of venous thromboembolism in cancer patients: An updated meta-analysis of randomized controlled trials.

Background: Cancer associated venous thromboembolism (VTE) results in significant morbidity and mortality. Low molecular weight heparin (LMWH) has been standard of care for treatment of cancer-associated VTE, however direct oral anticoagulants (DOACs) are emerging as alternative treatment options.

Objective: To compare the benefits and harms of DOACs versus LMWH for treatment of VTE in cancer.

Optical and dielectric properties of lead perovskite and iodoplumbate complexes: an ab initio study.

Organic-inorganic lead halide perovskites (APbI) have shown tremendous growth in solar cell efficiencies; however, our atomistic understanding of the intrinsic instability due to A-cation size effects is far from satisfactory. Here, we report a dispersion corrected density functional theory study of the influence of the A-cation size on the lattice structures of perovskite (α-cubic and γ-orthorhombic) and non-perovskite phases (δ-hexagonal and δ-orthorhombic) through isotropic (cesium and ammonium) and anisotropic cations (methylammonium, formamidinium and dabconium). We found that the local coordination environmental changes and noncovalent interactions are crucial in explaining the enthalpy of formation and relative energy stability.

Exploring the potential of iron to replace ruthenium in photosensitizers: a computational study.

In an effort to replace the widely used ruthenium metal complexes with low-cost, earth abundant iron complexes as photosensitizers for dye-sensitized solar cell (DSSC) applications, herein we report the computational design of heteroleptic iron complexes (FC1-3) coordinated with benzimidazole-phenylcarbene (C^N) ligands. DFT and TDDFT calculations predicted the stronger σ-donating and π-accepting nature of phenyl carbene ligands substituted with electron-withdrawing CF, donating -N(CH), and benzothiazine annulation than the imidazole carbene ligands (FC4); consequently, the metal-ligand bond distances and interactions that influence the ordering of charge transfer states with respect to metal centered states are altered in FC1-3 complexes. Detailed analysis based on energy decomposition analysis, spin density distribution analysis, and ab initio ligand field theory parameters were enabled to understand the nature of heteroleptic ligand interactions with the rest of the metal complex.

Benzimidazole-functionalized ancillary ligands for heteroleptic Ru(II) complexes: synthesis, characterization and dye-sensitized solar cell applications.

We have designed and synthesized heteroleptic Ru(ii) complexes with a pyridine-benzimidazole ligand (PYBI) for dye-sensitized solar cell (DSSC) applications. The PYBI ligand has major advantages by having the flexibility to introduce appropriate substituents at the four readily available positions through molecular engineering () compared to other ancillary bipyridyl-based ligands. We have substituted position A of the PYBI ligand with either electron-releasing triphenylamine () or pyrene ().

Bis(porphyrin)-anthraquinone triads: synthesis, spectroscopy, and photochemistry.

Molecular triads based on bis(porphyrin)-anthraquinone having azomethine bridge at the pyrrole-β position have been designed and synthesized. Both free-base AQ-(H2)2 and zinc AQ-(Zn)2 triads are characterized by elemental analysis, MALDI-MS, (1)H NMR, UV-visible, and fluorescence spectroscopy (steady-state and time-resolved) as well as electrochemical method. The absorption spectra of both Soret and Q-bands of the triads are red-shifted by 12-20 nm with respect to their monomer units.