[Possibilities of magnetic resonance morphometry and laboratory biomarkers in studying the progression of multiple sclerosis].

Objective: To show that magnetic resonance morphometry and laboratory biomarkers are promising methods for early detection of progressive forms of multiple sclerosis (MS).

Material And Methods: Eighty-one patients with MS were examined, magnetic resonance morphometry was performed in all of them, 60 patients were analyzed for neurofilament light chains (sNFL), phosphorylated neurofilament heavy chains (spNFH) and glial fibrillary protein (sGFAP) in serum by enzyme-linked immunosorbent assay.

Results: Brain volumes were negatively correlated with disease duration, EDSS score, 25-foot walk test score and 9-ring test and positively correlated with the Symbol-Numeric Test and the Montreal Cognitive Assessment.

[Carboxylation processes in cattle with different levels of productivity].

The experiments were conducted on bulls-analogs of the black-piebald and Simmental breed which differ from each other in the intensity of live weight gain (18-31%) as well as on lactating cows-analogs of the black-piebald breed which differ in the level of milk productivity (41-80%). The intensity of the carboxylation processes (CO2 fixation) as well as of protein and lipids biosynthesis in the liver of the bulls from a heavy-producing group (the second group) is shown to be considerably higher than in the low-producing animals (the first group). In venous blood plasm of the second group bulls the content of urea and citrate was higher (by 29-141 and 33%, respectively) than in the first group animals.