Publications by authors named "Malko Adan"
There has been a surge in studies implicating a role of vaginal microbiota in spontaneous preterm birth (sPTB), but most are associative without mechanistic insight. Here we show a comprehensive approach to understand the causative factors of preterm birth, based on the integration of longitudinal vaginal microbiota and cervicovaginal fluid (CVF) immunophenotype data collected from 133 women at high-risk of sPTB. We show that vaginal depletion of Lactobacillus species and high bacterial diversity leads to increased mannose binding lectin (MBL), IgM, IgG, C3b, C5, IL-8, IL-6 and IL-1β and to increased risk of sPTB.
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- Preterm birth (PTB) affects 8% of births in the UK, and a specialized clinic manages care for around 1000 women yearly, using regular ultrasound checks for cervical issues.
- During COVID-19, the NHS adapted by minimizing in-person visits to prevent virus spread, leading to a 54% reduction in face-to-face appointments and a shift to 64% remote consultations.
- Using quality improvement methods, the clinic implemented a new care pathway that maintained patient satisfaction and safety, with no reported COVID-19 cases among the patients during the study period.