Publications by authors named "Malkina N"

Disorders of the mineral balance often determine the symptoms, the severity of the course and the prognosis of many diseases. Primary hyperparathyroidism (PHPT) is a common endocrine disease caused by increased secretion of parathyroid hormone as a result of primary damage to the parathyroid glands. Diagnosis of PHPT is often difficult.

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In this study, the microbial communities of two nests of black garden ants ) in the hollows of stem branches of old apple trees were found to have similar species compositions: each community contained representatives of three species from the Bacillaceae family and one species of actinomycetes from the genus . In total, four types of bacilli and two actinomycetes were isolated. Actinomycetes were identified as -like and sp.

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Because of the spread of drug resistance, it is necessary to look for new antibiotics that are effective against pathogenic microorganisms. The purpose of this study was to analyse the species composition of actinobacteria isolated from the digestive tract of the millipedes and to determine their antimicrobial properties. Species identification was carried out on the basis of the morphological and culture properties and the sequence of the 16S rRNA gene.

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Objective: Reducing adverse effects in laparoscopic cholecystectomy (LCE) is important to avoid complications. After removal, the porta hepatis and gallbladder bed of liver were treated with pulse width modulated (PWM) red LED light with parameters λ = 625 ± 5 nm, full width at half maximum 17 nm, 76 Hz, duty cycle 23%, 15-30 mW/cm, and 0.9-1.

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Taxonomic properties of strain INA-1132 producing antibiotic INA-1132 are described. The antibiotic showed activity against grampositive bacteria and fungi. The strain was classified as belonging to the genus Streptomyces and by its taxomic characteristics is most close to S.

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An actinomycete strain designated as Actinomadura sp. INA 654 was isolated from a chernozem soil sample in the Voronezh Region by the soil sample treatment with millimetric waves (EHF band). The strain produced an antibiotic complex of 2 components, named A-654-I and A-654-II.

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An actinomycete strain designated as 2608 was isolated from a soil sample. When cultivated on various solid and liquid media, the strain was inactive. The strain exposure to ethidium bromide resulted in formation of a mutant producing an antibiotic active against some gram-positive bacteria.

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After exposure of an inactive actinomycete to ethidium bromide a stable mutant producing an antibiotic on a solid medium was isolated. The exposure to methylnitrosoguanidine provided the isolation of a more productive variant synthesizing the antibiotic in a liquid medium. By UV, IR, NMR and mass spectroscopy the antibiotic was identified as bruneomycin (streptonigrin).

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A set of parameters, such as pO2, pCO2, the content of glucose, glycogen, lactate, pyruvate, cholesterol, insulin, triglycerides, cAMP in the blood from the venous sinus has been investigated in puppies of Baikal seals during forced diving and rehabilitation. The dynamics of these parameters is presented.

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Two related antibiotics, 167-A and 167-B, were isolated from the fermentation broth of a mutant of an inactive wild strain of Amycolata autotrophica. Antibiotic 167-B was found to be cervinomycin A2; antibiotic 167-A is a new representative of the same group and has the structure of 18-O-demethyl cervinomycin A2.

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Inactive strains of actinomycetes isolated from natural sources were treated with ethidium bromide, an intercalating agent. After the treatment the cultures formed active variants at a frequency of more than 0.1 per cent which was rather high.

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Intravital microscopy revealed that 65% of all the m. cremaster's capillary bed were perfused at rest. The capillary functional reserve may play an important part in the topographical heterogeneity of the perfusion.

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An actinomycete strain designated as 4297 was isolated from a soil sample collected near Moscow. The strain produced a complex of two antibiotics. One of them had a broad antibacterial spectrum and, in terms of its physicochemical properties and X-ray structural evidence, was identified with griseoviridin.

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Screening of antibiotic-producing cultures among Actinomadura showed that definite species mainly produced antibiotics of the same groups. Thus, carminomycins were produced by all the 4 studied strains of A. carminata, maduramycins were produced by 3 strains of A.

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Novel antibiotics with in vitro activity against gram-positive bacteria were isolated from Actinomadura fulvescens INA 3321 and INA 3852. Conditions for biosynthesis and isolation of antibiotics 3321 and 3852, as well as their physicochemical and biological properties were studied. Chromatographic analysis of the antibiotics revealed that each of them contained two biologically active components.

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The RBC velocity, cell flux and tube hematocrit were measured in the arterial and venous ends of the rat cremaster capillaries. The widening of capillaries from the arterial to venous ends from 4.9 +/- 0.

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A culture of Actinoplanes ianthinogenes subsp. octamycini producing a polyenic antibiotic with the UV spectrum characteristic of octaens was isolated. Optimal conditions for biosynthesis of the antibiotic were developed and an active variant 4041-6 producing 2 mg of octamycin per 100 ml of the medium was selected.

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In screening of new antibiotics a streptomycete (strain 1136) was isolated from a soil sample of Armenia. It showed no antagonistic properties in streek cultures on agarized media. When grown under submerged conditions strain 1136 produced an antibiotic active against grampositive and gramnegative bacteria.

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