Efficient laser wakefield accelerator in pump depletion dominated bubble regime.

With the usage of the postcompression technique, few-cycle joule-class laser pulses are nowadays available extending the state of the art of 100 TW-class laser working at 10 Hz repetition. In this Letter, we explore the potential of wakefield acceleration when driven with such pulses. The numerical modeling predicts that 50% of the laser pulse energy can be transferred into electrons with energy above 15 MeV, and with charge exceeding several nanocoulombs for the electrons at hundreds of MeV energy.

Laser Proton Acceleration from a Near-Critical Imploding Gas Target.

The interaction between relativistic intense laser pulses and near-critical-density targets has been sought after in order to increase the efficiency of laser-plasma energy coupling, particularly for laser-driven proton acceleration. To achieve the density regime for high-repetition-rate applications, one elusive approach is to use gas targets, provided that stringent target density profile requirements are met. These include reaching the critical plasma density while maintaining micron-scale density gradients.

Simple few-shot method for spectrally resolving the wavefront of an ultrashort laser pulse.

We present a novel, to the best of our knowledge, and straightforward approach for the spatio-spectral characterization of ultrashort pulses. This minimally intrusive method relies on placing a mask with specially arranged pinholes in the beam path before the focusing optic and retrieving the spectrally resolved laser wavefront from the speckle pattern produced at focus. We test the efficacy of this new method by accurately retrieving chromatic aberrations, such as pulse-front tilt (PFT), pulse-front curvature (PFC), and higher-order aberrations introduced by a spherical lens.

Use of spatiotemporal couplings and an axiparabola to control the velocity of peak intensity.

This paper presents the first experimental realization of a scheme that allows for the tuning of the velocity of peak intensity of a focal spot with relativistic intensity. By combining a tunable pulse-front curvature with the axial intensity deposition characteristics of an axiparabola, an aspheric optical element, this system provides control over the dynamics of laser-wakefield accelerators. We demonstrate the ability to modify the velocity of peak intensity of ultrashort laser pulses to be superluminal or subluminal.

Real-time visualization of the laser-plasma wakefield dynamics.

The exploration of new acceleration mechanisms for compactly delivering high-energy particle beams has gained great attention in recent years. One alternative that has attracted particular interest is the plasma-based wakefield accelerator, which is capable of sustaining accelerating fields that are more than three orders of magnitude larger than those of conventional radio-frequency accelerators. In this device, acceleration is generated by plasma waves that propagate at nearly light speed, driven by intense lasers or charged particle beams.

Refractive plasma optics for relativistic laser beams.

The high intensities reached today by powerful lasers enable us to explore the interaction with matter in the relativistic regime, unveiling a fertile domain of modern science that is pushing far away the frontiers of plasma physics. In this context, refractive-plasma optics are being utilized in well established wave guiding schemes in laser plasma accelerators. However, their use for spatial phase control of the laser beam has never been successfully implemented, partly due to the complication in manufacturing such optics.

Femtosecond electron microscopy of relativistic electron bunches.

The development of plasma-based accelerators has enabled the generation of very high brightness electron bunches of femtosecond duration, micrometer size and ultralow emittance, crucial for emerging applications including ultrafast detection in material science, laboratory-scale free-electron lasers and compact colliders for high-energy physics. The precise characterization of the initial bunch parameters is critical to the ability to manipulate the beam properties for downstream applications. Proper diagnostic of such ultra-short and high charge density laser-plasma accelerated bunches, however, remains very challenging.

Energy-Conserving Theory of the Blowout Regime of Plasma Wakefield.

We present a self-consistent theory of strongly nonlinear plasma wakefield (bubble or blowout regime of the wakefield) based on the energy conservation approach. Such wakefields are excited in plasmas by intense laser or particle beam drivers and are characterized by the expulsion of plasma electrons from the propagation axis of the driver. As a result, a spherical cavity devoid of electrons (called a "bubble") and surrounded by a thin sheath made of expelled electrons is formed behind the driver.

Ultra-high dose rate radiation production and delivery systems intended for FLASH.

Higher dose rates, a trend for radiotherapy machines, can be beneficial in shortening treatment times for radiosurgery and mitigating the effects of motion. Recently, even higher doses (e.g.

Bright synchrotron radiation from relativistic self-trapping of a short laser pulse in near-critical density plasma.

In a dense gas plasma a short laser pulse propagates in a relativistic self-trapping mode, which enables the effective conversion of laser energy to the accelerated electrons. This regime sustains effective loading which maximizes the total charge of the accelerating electrons, that provides a large amount of betatron radiation. The three-dimensional particle-in-cell simulations demonstrate how such a regime triggers x-ray generation with 0.

Real-world data and treatment patterns of patients with lower urinary tract symptoms due to benign prostatic hyperplasia in Germany: an observational study using health insurance claims data.

Purpose: Benign prostatic hyperplasia (BPH) is associated with lower urinary tract symptoms (LUTS), representing one of the most common urological conditions. However, insights into the actual healthcare of this patient cohort in Germany are scarce. We aimed to retrospectively analyse management patterns of patients with LUTS in Germany using health insurance claims databases.

The Mechanism of Action of cTIND for Minimally Invasive Ischemic Incision of the Prostate: In Vivo Study.

Objectives: To understand the histologic changes of prostate tissue induced by temporary implantable nitinol device (cTIND) in a canine model.

Methods: The cTIND is a small, symmetric device comprised of nitinol wire loops welded together on an axis, which exert radial force on the tissue to induce a targeted ischemic effect. The cTIND was implanted in three live canine models, which were monitored for 14 days post-index procedure.

Electrostatic shock acceleration of ions in near-critical-density plasma driven by a femtosecond petawatt laser.

With the recent advances in ultrahigh intensity lasers, exotic astrophysical phenomena can be investigated in laboratory environments. Collisionless shock in a plasma, prevalent in astrophysical events, is produced when a strong electric or electromagnetic force induces a shock structure in a time scale shorter than the collision time of charged particles. A near-critical-density (NCD) plasma, generated with an intense femtosecond laser, can be utilized to excite a collisionless shock due to its efficient and rapid energy absorption.

Effects of the Transverse Instability and Wave Breaking on the Laser-Driven Thin Foil Acceleration.

Acceleration of ultrathin foils by the laser radiation pressure promises a compact alternative to the conventional ion sources. Among the challenges on the way to practical realization, one fundamental is a strong transverse plasma instability, which develops density perturbations and breaks the acceleration. In this Letter, we develop a theoretical model supported by three-dimensional numerical simulations to explain the transverse instability growth from noise to wave breaking and its crucial effect on stopping the acceleration.

Tunable High Spatio-Spectral Purity Undulator Radiation from a Transported Laser Plasma Accelerated Electron Beam.

Undulator based synchrotron light sources and Free Electron Lasers (FELs) are valuable modern probes of matter with high temporal and spatial resolution. Laser Plasma Accelerators (LPAs), delivering GeV electron beams in few centimeters, are good candidates for future compact light sources. However the barriers set by the large energy spread, divergence and shot-to-shot fluctuations require a specific transport line, to shape the electron beam phase space for achieving ultrashort undulator synchrotron radiation suitable for users and even for achieving FEL amplification.

Shaping of a laser-accelerated proton beam for radiobiology applications via genetic algorithm.

Laser-accelerated protons have a great potential for innovative experiments in radiation biology due to the sub-picosecond pulse duration and high dose rate achievable. However, the broad angular divergence makes them not optimal for applications with stringent requirements on dose homogeneity and total flux at the irradiated target. The strategy otherwise adopted to increase the homogeneity is to increase the distance between the source and the irradiation plane or to spread the beam with flat scattering systems or through the transport system itself.

Axiparabola: a long-focal-depth, high-resolution mirror for broadband high-intensity lasers.

Diffraction puts a fundamental limit on the distance over which a light beam can remain focused. For about 30 years, several techniques to overcome this limit have been demonstrated. Here, we propose a reflective optics, namely, the axiparabola, that allows to extend the production of "diffraction-free" beams to high-peak-power and broadband laser pulses.

Fast dose fractionation using ultra-short laser accelerated proton pulses can increase cancer cell mortality, which relies on functional PARP1 protein.

Radiotherapy is a cornerstone of cancer management. The improvement of spatial dose distribution in the tumor volume by minimizing the dose deposited in the healthy tissues have been a major concern during the last decades. Temporal aspects of dose deposition are yet to be investigated.

Energy-Chirp Compensation in a Laser Wakefield Accelerator.

The energy spread in laser wakefield accelerators is primarily limited by the energy chirp introduced during the injection and acceleration processes. Here, we propose the use of longitudinal density tailoring to reduce the beam chirp at the end of the accelerator. Experimental data sustained by quasi-3D particle-in-cell simulations show that broadband electron beams can be converted to quasimonoenergetic beams of ≤10% energy spread while maintaining a high charge of more than 120 pC.

Stable femtosecond X-rays with tunable polarization from a laser-driven accelerator.

Technology based on high-peak-power lasers has the potential to provide compact and intense radiation sources for a wide range of innovative applications. In particular, electrons that are accelerated in the wakefield of an intense laser pulse oscillate around the propagation axis and emit X-rays. This betatron source, which essentially reproduces the principle of a synchrotron at the millimeter scale, provides bright radiation with femtosecond duration and high spatial coherence.

Physical mechanism of the electron-ion coupled transverse instability in laser pressure ion acceleration for different regimes.

In radiation pressure ion acceleration (RPA) research, the transverse stability within laser plasma interaction has been a long-standing, crucial problem over the past decades. In this paper, we present a one-dimensional two-fluid theory extended from a recent work Wan et al. Phys.

High-Brilliance Betatron γ-Ray Source Powered by Laser-Accelerated Electrons.

Recent progress in laser-driven plasma acceleration now enables the acceleration of electrons to several gigaelectronvolts. Taking advantage of these novel accelerators, ultrashort, compact, and spatially coherent x-ray sources called betatron radiation have been developed and applied to high-resolution imaging. However, the scope of the betatron sources is limited by a low energy efficiency and a photon energy in the 10 s of kiloelectronvolt range, which for example prohibits the use of these sources for probing dense matter.

Publisher Correction: Control of laser plasma accelerated electrons for light sources.

The original version of this Article contained an error in the last sentence of the first paragraph of the Introduction and incorrectly read 'A proper electron beam control is one of the main challenges towards the Graal of developing a compact alternative of X-ray free-electron lasers by coupling LWFA gigaelectron-volts per centimetre acceleration gradient with undulators in the amplification regime in equation 11, nx(n-β) x β: n the two times and beta the two times should be bold since they are vectorsin Eq. 12, β should be bold as well.' The correct version is 'A proper electron beam control is one of the main challenges towards the Graal of developing a compact alternative of X-ray free-electron lasers by coupling LWFA gigaelectron-volts per centimetre acceleration gradient with undulators in the amplification regime.