The results of study of pertussis component of DPT vaccine produced in USSR and some other countries.

The paper presents the results of testing of 16 vaccines under the letter code from 8 countries received from WHO. These vaccines differed both in toxicity and potency. Six lots contained from 1.

[A study of toxic substances in pertussis cultures].

For the purpose of studying the toxic properties of pertussis strains with different agglutination composition and to ascertain the interrelationship between the action of the toxic substances and the serological type of the strains the author used a test of the weight change in albino mice to which crude and heated (at 56 degrees C for 10 minutes) suspensions of the strains of various serological types were injected intraperitoneally. The toxic properties were checked in 17 strains. The test of the change of the animal body weight with the determination of the regression coefficient permitted to determine roughly the presence of the toxic substances in the strains; the action of the thermostable dermonecrotic toxin and thermostable endotoxin was expressed with greater constancy than that of the lymphocytosis stimulating factor.