Oral Intake of Lactobacilli Can Be Helpful in Symptomatic Bacterial Vaginosis: A Randomized Clinical Study.

Objective: The aim of the study was to explore a role of oral intake of a mixture of 3 Lactobacillus species in recurrence of bacterial vaginosis (BV).

Materials And Methods: A phase 2 randomized parallel group prospective placebo-controlled study conducted at 7 clinical centers enrolled 18- to 45-years-old women with recent symptomatic BV cured with metronidazole. Within 48 hours after completion of metronidazole therapy, eligible women received 1 capsule of the verum (5.

[An experimental study of the anti-ulcer effect of administering sodium succinate and a solution of whey in immobilization stress].

The experiments carried out on the model of immobilization stress permit establishing the antiulcer effect of preventive introduction of sodium succinate solution, milk serum solution and solution of milk serum with sodium succinate. A decrease in the degree and number of ulcers and in the integrative indices characterizing the ulcer process after introduction of the studied drugs was accompanied by a fall of the intensity of lipid peroxidation processes.

[An electron microscopic analysis of the stimulating and toxic effects of mumie-containing preparations].

Ultrastructural changes of myocardium cells, neurons of sensorimotor cerebral cortex, endothelium of blood microvessels were registered by transmissive electron microscopy in mice receiving rock balm preparations per os. Both stimulating and toxic effects were observed dependently on used concentrations. This necessitates dosage to be strictly observed.

[Combined use of antitubercular drugs and metabolites of the tricarboxylic acid cycle in experimental tuberculosis].

The efficacy of a combined use of isoniazid together with polyzid prolonged tuberculostatic and tricarboxylic acid cycle metabolites was experimentally studied in guinea pigs. Mortality rates, pathomorphologic test data and the extent of tuberculous affection in the animals confirm a fairly high efficacy of prolonged polyzid in combination with succinate and malate as pathogenetic drugs.

[Effect of exogenous succinate on the contents of tricarboxylic acid cycle metabolites of the liver].

The paper deals with dynamics of tricarboxylic cycle metabolites in the liver after subcutaneous injection of succinate in a dose of 100 mg/kg to guinea pigs. Before the preparation administration the highest level was marked for succinate, malate and citrate. 3 h after the administration the succinate content increased by 57% and 6 h later it returns to the initial level.

[Effect of tubaside and sodium succinate on oxidative phosphorylation and p-hydroxylation in the liver].

Tubaside causes disturbances in oxidative phosphorylation of the liver mitochondria. Sodium succinate administered during tubaside intoxication favours normalization of the oxygen uptake rate in state 3 and the ADP phosphorylation rate. Sodium succinate weakens the toxic effect of tubaside and favours normalization of p-hydroxylation in the liver.

[Dynamics of the fatty acid composition of guinea pig liver and lung mitochondrial lipids in experimental tuberculosis].

Composition of fatty acids was distinctly different in lipids of guinea pig liver and lung mitochondria; unsaturated polyenic acids containing 18 carbon atoms prevailed in lipids of liver mitochondria, saturated fatty acids dominated in lipids of lung mitochondria and monoenic acids were found among unsaturated fatty acids of the fraction. Experimental tuberculosis was accompanied by dissimilar alterations in fatty acid composition of lipids from mitochondria of these tissues: content of saturated fatty acids was increased in liver mitochondria and the content of unsaturated fatty acids--in lung mitochondria.