Publications by authors named "Malin Nygren Bonnier"

Background: Physical activity is thought to be a key component in reducing postoperative complications following major abdominal surgery. The available literature on exercise interventions following radical cystectomy in patients with bladder cancer is scarce but suggests that physical activity and exercise might improve physical function and health-related quality of life, thus calling for further investigation. The CanMoRe-trial is a single-blinded randomised controlled trial (Clinicals Trials NCT03998579 25/06/2019), aimed at evaluating the impact of an exercise intervention in primary care following robot-assisted radical cystectomy.

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  • Post-acute COVID-19 syndrome (PACS) occurs in patients even after mild infections, and this study investigates the link between PACS and microvascular endothelial dysfunction.* -
  • Out of 92 PACS patients, 41% showed signs of microvascular endothelial dysfunction, with increased levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) correlated to this dysfunction.* -
  • The findings suggest that microvascular endothelial dysfunction is common in PACS, particularly in those with rising NT-proBNP levels, highlighting the need for further research on this condition.*
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  • Postural orthostatic tachycardia syndrome (POTS) affects about 30% of individuals with post-COVID-19 condition, leading to significant physical and psychological limitations.
  • A study evaluated tailored endurance and strength training over 12 weeks for 26 participants, with high adherence rates (76% for exercise and 96% completion).
  • The intervention showed improvements in symptoms and physical/psychological functions, suggesting that future research can be conducted with minor adjustments to the evaluation methods used.
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  • The study looked at the experiences of nurses who help patients recover after being in the Intensive Care Unit (ICU).
  • Nurses interviewed shared challenges they face when trying to help these patients move again and said they often need help from physiotherapists.
  • Working together with physiotherapists makes it easier for nurses to help patients get better, which is important for the patients' overall health and independence.
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Introduction: After radical cystectomy physical activity is important to reduce risk of complications, but patients with urinary bladder cancer have difficulties in achieving general recommendations on physical activity and exercise. The aim of this randomised controlled trial was therefore to evaluate the effects of a physical exercise programme in primary care, following discharge from hospital after robot-assisted radical cystectomy for urinary bladder cancer.

Materials And Methods: Patients with urinary bladder cancer scheduled for robot-assisted radical cystectomy at Karolinska University Hospital, Sweden between September 2019 and October 2022 were invited to join the study.

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Background: Cardiac surgery is associated with a period of postoperative bed rest. Although early mobilization is a vital component of postoperative care, for preventing complications and enhancing physical recovery, there is limited data on routine practices and optimal strategies for early mobilization after cardiac surgery. The aim of the study was to define the timing for the first initiation of out of bed mobilization after cardiac surgery and to describe the type of mobilization performed.

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Background: Few studies consider both radiological and functional outcomes in COVID-19 survivors treated in the intensive care unit (ICU). We investigated clinical findings and pulmonary abnormalities on chest computed tomography (CT) and compared outcomes of severe versus mild-moderate acute respiratory distress syndrome (ARDS) on long-term follow-up.

Methods: This longitudinal cohort study included 118 COVID-19 patients (median age, 58 years; 79% men).

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Objectives: Knowledge of clinical practice regarding mobilisation after surgery is lacking. This study therefore aimed to reveal current mobilisation routines after abdominal and cardiothoracic surgery and to identify factors associated with mobilisation within 6 hours postoperatively.

Design: A prospective observational national multicentre study.

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Objective: The goal of this study was to explore the patient-physical therapist interaction and the physical therapist's experience of the introductory session for mechanical insufflation-exsufflation (MI-E) device treatment for patients with progressive neurological disease.

Methods: Qualitative content analysis of participant's observation of interaction between patients and physical therapists during 9 MI-E introduction sessions in different clinical care settings and 10 follow-up interviews with 6 physical therapists.

Results: The introduction of MI-E emerged as a process of instilling a sense of security in the patient.

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Background: Complications after radical cystectomy for urinary bladder cancer are common. Physical activity after surgery is thought to reduce complications. However, patients with urinary bladder cancer have low levels of physical activity, and interventions supporting physical exercise are needed.

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  • - Post-acute COVID-19 syndrome (PACS) is linked to cardiovascular issues like postural orthostatic tachycardia syndrome (POTS), leading to a variety of lingering symptoms long after the initial infection, although the underlying mechanisms remain unclear.
  • - A study analyzed 21 healthy individuals and 42 PACS patients (split into those with and without POTS) nearly 18 months post-infection, focusing on changes in plasma proteins, cytokine levels, and sphingolipid profiles.
  • - Results showed that around 200 proteins were significantly dysregulated in both PACS groups, with common alterations in immune and metabolic processes, alongside significant upregulation of certain cytokines and sphingolipids, indicating
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  • Home-based interventions are increasingly important in health care, and this 8-week pilot study focused on implementing pulmonary rehabilitation at home for COPD patients in Sweden.
  • The program involved the use of fitness trackers, weekly health coaching, and video-guided exercises, targeting patients aged 40 and older who were clinically stable.
  • Results showed high adherence to health coaching and exercise videos, with some patients achieving increased daily step counts, although there were no significant improvements in overall quality of life.
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Background: Early mobilisation is strongly recommended following abdominal cancer surgery, but evidence on how to structure early mobilisation to improve outcomes and support patient adherence is lacking. Pedatim® (Phystec) is a novel digital tool designed to support mobilisation in hospital settings using prescribed activities and goals on a tablet. The aim of this study was to evaluate the feasibility of the Pedatim tablet to enhance mobilisation following abdominal cancer surgery.

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Background: Epidemics have historically been accompanied by stigma and discrimination. Disease-related stigma has often been shown to have severe consequences for physical, mental and social wellbeing and lead to barriers to diagnosis, treatment and prevention. The aims of this study were to investigate if a HIV-related stigma measure could be adapted and valid and reliable to measure COVID-19-related stigma, and also to investigate levels of self-reported stigma and related factors among people in Sweden with experience of COVID-19 and compare levels of COVID-19-related stigma versus HIV-related stigma among persons living with HIV who had experienced a COVID-19 event.

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Introduction: Postoperative complications and readmission to hospital after major cancer surgery are common. Early mobilisation in hospital is thought to reduce complications, and patients are recommended to mobilise for at least 2 h on the day of surgery, and thereafter at least 6 h per day. Evidence for early mobilisation is limited and therefore also how early mobilisation may influence the development of postoperative complications.

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Background: With ~ 50 million individuals suffering from post-COVID condition (PCC), low health related quality of life (HRQoL) is a vast problem. Common symptoms of PCC, that persists 3 months from the onset of COVID-19 are fatigue, shortness of breath and cognitive dysfunction. No effective treatment options have been widely adopted in clinical practice.

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Background: This multicentre study explores the effects of pre-operative exercise on physical fitness, post-operative complications, recovery, and health-related quality of life in older individuals with low pre-operative physical capacity scheduled to undergo surgery for colorectal cancer. We hypothesise that this group of patients benefit from pre-operative exercise in terms of improved pre-operative physical function and lower rates of post-operative complications after surgery compared to usual care. Standardised cancer pathways in Sweden dictate a timeframe of 14-28 days from suspicion of cancer to surgery for colorectal cancer.

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Introduction: Long COVID-19, where symptoms persist 12 weeks after the initial SARS-CoV-2-infection, is a substantial problem for individuals and society in the surge of the pandemic. Common symptoms are fatigue, postexertional malaise and cognitive dysfunction. There is currently no effective treatment and the underlying mechanisms are unknown, although several hypotheses exist, with chronic inflammation as a common denominator.

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Background And Aim: Students' expectations of their future profession may have an impact on their professional development. This study aimed to describe first and final year physiotherapy students' expectations of their future profession.

Methods: A total of 96 respondents participated; 45 students in their first semester 2006, and 51 students in their final semester 2014.

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Purpose: Most patients treated in a hospital setting are fully or partially immobilised. The Activity Board (Träningstavlan Phystec) is a useful tool to enhance mobilisation after major abdominal cancer surgery. Knowledge of patient experiences of the mobilisation tool is crucial in implementing the Activity Board in health care.

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  • Women with obstructive pulmonary disease are increasingly participating in non-pharmacological rehabilitation methods, but their experiences with physical activity need to be better understood.
  • A study interviewed 15 women about their participation in exercise interventions and their overall experiences with physical activity throughout their lives, identifying key themes related to their motivation and challenges.
  • Findings revealed that women's gender roles significantly impact their ability to engage in physical activity, indicating that programs promoting exercise should address these gender-specific barriers.
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Background & Aims: Abnormal levels of hemoglobin, C-reactive protein (CRP) and albumin are common in people with gastrointestinal cancer. The hypothesis was that this is of importance for physical performance in older persons in the perioperative context. Thus, the aim was to evaluate the association between hemoglobin, CRP and albumin and physical performance before and after abdominal cancer surgery in older patients.

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Objective: The aim of this study was to investigate if mobilization out of bed, within 2 hours after abdominal surgery, improved participants' respiratory function and whether breathing exercises had an additional positive effect.

Methods: Participants were 214 consecutively recruited patients who underwent elective open or robot-assisted laparoscopic gynecological, urological, or endocrinological abdominal surgery with an anesthetic duration of >2 hours. They were recruited to a randomized controlled trial.

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Major clinical centers in Sweden have witnessed an inflow of patients with chronic symptoms following initial outpatient care for coronavirus disease-2019 (COVID-19) infection, suggestive of postural orthostatic tachycardia syndrome. This report presents the first case series of 3 Swedish patients diagnosed with postural orthostatic tachycardia syndrome more than 3 months after the primary COVID-2019 infections. ().

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