Background/aim: P21 is a cyclin-dependent kinase inhibitor regulating the cell cycle as a tumor suppressor. Using a p21 immunohistochemistry (IHC) assay, we compared tumor p21 levels with conventional clinico-pathological criteria in primary pancreatic endocrine tumor subsets with and without liver metastases.
Materials And Methods: Sections from tissue microarray (TMA) including 13 archival metastatic primary and 18 non-metastatic primary pancreatic endocrine carcinomas/tumors (MP-PECAs/NMP-PETs) were stained with a monoclonal anti-p21 primary antibody.
Introduction C-reactive protein (CRP) has been reported as a predictor of the severity of acute pancreatitis (AP). However, there is conflicting evidence in the literature. The proposed cut-off values and intervals for best prediction include an absolute value of 150 at 48 hours; an absolute value of 190 at 48 hours; and the interval change in CRP of 90 at 48 hours.
View Article and Find Full Text PDFObjective: To compare two premier Pakistani medical journals for errors in references of original articles published in the year 2008.
Methods: All original articles of the Journal of Pakistan Medical Association and the Journal of the College of Physicians and Surgeons Pakistan published in 2008 were included in the study. References pertaining to journals were included in the study, whereas references pertaining to other sources such as books internet articles, websites and newspapers were excluded.