Publications by authors named "Malik Irshadullah"
The present study aimed to evaluate the histologic, histochemical, and immunohistochemical changes in buffalo livers with cystic echinococcosis. Noninfected and infected livers were collected from the freshly slaughtered buffalo at the Aligarh abattoir. Small pieces of both infected and noninfected livers ( = 5) were cut and processed for histologic and histochemical studies.
View Article and Find Full Text PDFThe present study assessed the antioxidants and oxidative stress markers in the liver of buffalo naturally infected with cystic echinococcosis. Infected and non-infected livers were collected from the abattoir, and processed to determine the markers of oxidative stress and antioxidants. In addition, samples were also analyzed for liver tissue injury markers.
View Article and Find Full Text PDFCystic echinococcosis is a socioeconomically important parasitic disease caused by the larval stage of the canid tapeworm Echinococcus granulosus, afflicting millions of humans and animals worldwide. The development of a vaccine (called EG95) has been the most notable translational advance in the fight against this disease in animals. However, almost nothing is known about the genomic organisation/location of the family of genes encoding EG95 and related molecules, the extent of their conservation or their functions.
View Article and Find Full Text PDFCystic echinococcosis (CE), a zoonotic disease caused by tapeworms of the species complex Echinococcus granulosus sensu lato, represents a substantial global health and economic burden. Within this complex, E. granulosus sensu stricto (genotypes G1 and G3) is the most frequent causative agent of human CE.
View Article and Find Full Text PDFEchinococcus granulosus sensu stricto (s.s.) is the major cause of human cystic echinococcosis worldwide and is listed among the most severe parasitic diseases of humans.
View Article and Find Full Text PDFArticle Synopsis
- Tapeworms from the Echinococcus granulosus complex cause cystic echinococcosis, a severe zoonotic disease prioritized by the World Health Organization.
- Accurate taxonomy of these tapeworms is crucial for understanding their impact on human and animal health due to their genetic diversity and the existence of different species and genotypes.
- Recent research using Bayesian phylogeny has provided strong evidence that genotypes G6/G7 and G8/G10 are distinct species, differentiated by their host associations, geographical distributions, and limited gene flow.
Article Synopsis
- * The study aimed to explore the genetic diversity and geographic distribution of genotype G3, previously under-researched due to unclear definitions, by sequencing mitochondrial DNA from 39 G3 samples.
- * Findings showed significant genetic variation within G3 and identified the Middle East, particularly Turkey and Iran, as the likely origin of this genotype, despite it being less prevalent compared to genotype G1.
Background: Stray dogs are considered potential reservoirs for zoonotic diseases. Previous helminthic surveys in Iran, have accounted for mainly species of nematodes and cestodes, and rarely digeneans.
Methods: We accessed 42 car-crashed stray dogs from the Farah Abad Region in the Mazandaran Province (North Iran) between Oct 2012 and Dec 2013, to be inspected for parasites.
Article Synopsis
- Cystic echinococcosis is a disease caused by the Echinococcus granulosus parasite, which has multiple genotypes, with G1-G3 being the most common in humans.
- The study aims to clarify the genetic relationships and taxonomy of these genotypes by analyzing mitochondrial and nuclear DNA sequences from samples collected from various intermediate host species across multiple countries.
- Findings suggest that G1 and G3 can be classified as a single species based on nuclear data, while G2 is not a distinct genotype and should be excluded from classification lists.