Publications by authors named "Malihatosadat Gholam-Zadeh"
Article Synopsis
- Loss of ovarian function leads to reduced estrogen levels, promoting increased osteoclast (OC) activity and bone resorption, particularly after ovariectomy (OVX) in mice.
- Estrogen (E) was found to reduce OC size and inhibit bone resorption both in vivo and in vitro, primarily through its interaction with estrogen receptor alpha (ERα) and its downstream signaling pathways.
- The study indicates that E forms a complex with SHP2 and c-Src to inhibit c-Src activation, which disrupts the signaling necessary for actin ring formation in OCs, ultimately decreasing bone resorption through a non-genomic mechanism.
Dauricine (DAC), an isoquinoline alkaloid, exhibits anti-inflammatory activity. We hypothesized that DAC may prevent the inflammatory bone loss induced by lipopolysaccharide (LPS). LPS-induced bone loss was decreased by DAC in female C57BL/6J mice as evaluated by micro-computerized tomography (μCT) analysis.
View Article and Find Full Text PDFLycorine, a plant alkaloid, exhibits anti-inflammatory activity by acting in macrophages that share precursor cells with osteoclasts (OCs). We hypothesized that lycorine might decrease bone loss by acting in OCs after lipopolysaccharide (LPS) stimulation, since OCs play a main role in LPS-induced bone loss. Microcomputerized tomography (CT) analysis revealed that lycorine attenuated LPS-induced bone loss in mice.
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