Association between DPP6 gene rs10260404 polymorphism and increased risk of sporadic amyotrophic lateral sclerosis (sALS): a meta-analysis.

Background: Sporadic amyotrophic lateral sclerosis (sALS) is a severe neurodegenerative disease characterized by continuous diminution of motor neurons in the brain and spinal cord. Earlier studies indicated that the DPP6 gene variant has a role in the development of sALS. This meta-analysis was designed to uncover the role of rs10260404 polymorphism of the DPP6 gene and its association with sALS.

Drug and Anti-Viral Peptide Design to Inhibit the Monkeypox Virus by Restricting A36R Protein.

Most recently, monkeypox virus (MPXV) has emanated as a global public health threat. Unavailability of effective medicament against MPXV escalates demand for new therapeutic agent. In this study, in silico strategies were conducted to identify novel drug against the A36R protein of MPXV.

Functional Analysis of Hypothetical Proteins of Reveals the Presence of Virulence Factors and Growth-Related Enzymes With Therapeutic Potential.

, an aquatic pathogen, is a major concern in the shrimp aquaculture industry. Several strains of this pathogen are responsible for causing acute hepatopancreatic necrosis disease as well as other serious illness, both of which result in severe economic losses. The genome sequence of two pathogenic strains of , MSR16 and MSR17, isolated from Bangladesh, have been reported to gain a better understanding of their diversity and virulence.

Deciphering the role of predicted miRNAs of polyomaviruses in carcinogenesis.

Human polyomaviruses are relatively common in the general population. Polyomaviruses maintain a persistent infection after initial infection in childhood, acting as an opportunistic pathogen in immunocompromised populations and their association has been linked to carcinogenesis. A comprehensive understanding of the underlying molecular mechanisms of carcinogenesis in consequence of polyomavirus infection remains elusive.

Functional Annotation of Hypothetical Proteins From the B13 Strain and Its Association With Pathogenicity.

B13 strain is a rod-shaped gram-negative bacterium that belongs to the family. It can cause respiratory and urinary tract infections, and is responsible for several outbreaks in hospitals. has become an important pathogen and an emerging global threat because of its opportunistic and multidrug resistant ability.

Modeling mRNA-based vaccine YFV.E1988 against yellow fever virus E-protein using immuno-informatics and reverse vaccinology approach.

To surmount constraints of live-attenuated vaccines we have designed mRNA vaccine using envelope protein as a target antigen. From the alignment of 216 envelope proteins, a consensus sequence was obtained which was used for codon optimization. The secondary structure was predicted using Mfold and RNAfold tool.

Determinants of the Early Childhood Development Index among children aged < 5 years in Bangladesh, Costa Rica and Ghana: a comparative study.

Background: Early child development is a crucial factor for children that controls health and well-being in later life.

Aims: To determine the influence of sociodemographic factors on the Early Child Development Index (ECDI) among children aged < 5 years.

Methods: The analysis was performed using cross-sectional survey data from 2019, 2017-2018 and 2018 Multiple Indicator Cluster Surveys from Bangladesh, Ghana and Costa Rica, respectively.

Fenugreek steroidal saponins hinder osteoclastogenic bone resorption by targeting CSF-1R which diminishes the RANKL/OPG ratio.

Osteoporosis is skeletal fragility caused by the excessive bone resorption due to osteoclastogenesis. But current drugs are less bioavailable and possess higher toxicity. Our study was conducted to identify safe oral bioavailable drugs from Fenugreek steroidal saponins and to delineate underlying mechanism of them to lower the osteoclastogenic bone resorption.

Regional variations of child development index in Bangladesh.

Early development is a vital phase in childhood life. The study aimed to identify factors that were associated with the early development of 36-59 months children in Bangladesh. The findings of this study will formulate the design of appropriate policy and programmed responses.

Sociodemographic factors and early marriage among women in Bangladesh, Ghana and Iraq: An illustration from Multiple Indicator Cluster Survey.

Early marriage is a form of violation of child rights to grow and develop. The Sustainable Development Goals had included early marriage in target 5.3, aiming to eliminate by 2030.